Home Proteases Tyrosinase

Tyrosinase

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S1021 Dasatinib (BMS-354825) Dasatinib is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively. Dasatinib induces autophagy and apoptosis with anti-tumor activity.
Cancer Cell, 2025, S1535-6108(25)00070-4
Mil Med Res, 2025, 12(1):83
Nat Commun, 2025, 16(1):4069
Verified customer review of Dasatinib (BMS-354825)
S1005 Axitinib (AG-013736) Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively.
Cancer Cell, 2025, S1535-6108(25)00070-4
Chem Biol Interact, 2025, 418:111628
Development, 2025, 152(13)dev204684
Verified customer review of Axitinib (AG-013736)
S2375 Aloin (Barbaloin) Aloin (Barbaloin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.
Cytotechnology, 2025, 77(4):137
Nat Prod Commun, 2023, 18(5): 1–11
Nan Fang Yi Ke Da Xue Xue Bao, 2023, 43(5):702-709
S2263 Arbutin Arbutin (Uva, p-Arbutin, β-Arbutin) is a tyrosinase inhibitor with IC50 of 0.9 mM and 0.7 mM for Monophenolase and Diphenolase, respectively.
Translational Oncology, September 2023, 101712
Kocaeli Üniversitesi Sağlık Bilimleri Dergisi, May 2025, 70-77
Transl Oncol, 2023, 35:101712
S3783 Echinacoside Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions. This compound, one of the phenylethanoids isolated from the stems of Cistanche salsa, elicits neuroprotection by activating Trk receptors and their downstream signal pathways. It also has a remarkable antiosteoporotic activity.
Antioxidants, 29 October 2023, 1925
Frontiers in Pharmacology, 25 February 2022, 848813
Antioxidants (Basel), 2023, 10.3390/antiox12111925
S6237 2-Ketoglutaric acid (alpha-ketoglutarate) 2-Ketoglutaric acid (alpha-ketoglutarate) is a key molecule in the TCA cycle, playing a fundamental role in determining the overall rate of this important metabolic process. In the TCA cycle, it is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase, which functions as a key control point of the TCA cycle. This compound is a reversible inhibitor of tyrosinase.
Cellular and Molecular Life Sciences, 2025, 217
International Journal of Biological Sciences, 2021, 1250-1262
Int J Biol Sci, 2021, 17(5):1250-1262
S9111 Isorhamnetin Isorhamnetin (3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol), a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity.
Cytotechnology, 2025, 101
Frontiers in Pharmacology, 2024, 1290868
Front Pharmacol, 2023, 14:1290868
S4739 Oxyresveratrol Oxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene), a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.
International Journal of Molecular Sciences, 2022, 15102
Int J Mol Sci, 2022, 23(23)15102
S1652 Monobenzone Monobenzone(Benoquin) is a compound used as a topical agent for medical depigmentation. It can specifically block tyrosinase.Monobenzone can be used to induce animal models of Vitiligo.
Front Genet, 2020, 11:1000
S5174 Kojic acid Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives.
Int J Mol Sci, 2017, 18(9)