Tyrosinase

Inhibitory Selectivity

Tyrosinase Products

Catalog No. Information Product Use Citations Product Validations
S4921

MNS (3,4-Methylenedioxy-β-nitrostyrene)

MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.

S1652

Monobenzone

Monobenzone is a compound used as a topical agent for medical depigmentation. It can specifically block tyrosinase.

S4132

Deoxyarbutin

DeoxyArbutin is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM.

S6237

2-Ketoglutaric acid

2-Ketoglutaric acid, also known as alpha-ketoglutarate and AKG, is a key molecule in the TCA cycle, playing a fundamental role in determining the overall rate of this important metabolic process. In the TCA cycle, AKG is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase, which functions as a key control point of the TCA cycle. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase.

S4571

Hexylresorcinol

Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, is a potent inhibitor of mushroom tyrosinase. The IC50 values of hexylresorcinol for monophenolase is 1.24 μM and for diphenolase is 0.85 μM.

S6272

Glycolic acid

Glycolic acid (or hydroxyacetic acid) is the smallest alpha-hydroxy acid. Due to its excellent capability to penetrate skin, glycolic acid is often used in skin care products, most often as a chemical peel. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

S2375

Aloin

Aloin, a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.

S2263

Arbutin

Arbutin is a tyrosinase inhibitor with an IC50 of 1.09 mM.

S4739

Oxyresveratrol

Oxyresveratrol, a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.

S9284

Aloesin

Aloesin is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro.

S4997

4-Butylresorcinol

4-Butylresorcinol is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.

S3691

4-Chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid

4-Chlorosalicylic acid was used in sensitive spectrofluorometric determination of terbium in mixed rare earths and preparation of poly(4-chlorosalicylic acid-formaldehyde) via condensation with formaldehyde. 4-Chlorosalicylic acid is a pharmaceutical intermediate. Inhibits monophenolase and diphenolase activity with IC50s of 1.89 mM and 1.10 mM. Potent antimicrobial activity. Against E. coli with the MIC of 250 μg/mL and with the MBC of 500 μg/mL.

S9089

Magnoflorine

Magnoflorine, an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase.

S5174

Kojic acid

Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives.

S9111

Isorhamnetin

Isorhamnetin, a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity.

S9376

Benzylacetone

Benzylacetone is an attractant compound in flowers. Benzylacetone exhibits potent and reversible antityrosinase (mushroom) activity, with IC50s of 2.8 mM and 0.6 mM for monophenolase and diphenolase, respectively.

S6221

Methyl cinnamate

Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.

S3783

Echinacoside

Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions. Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche salsa, elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Echinacoside also has a remarkable antiosteoporotic activity.

Catalog No. Information Product Use Citations Product Validations
S4921

MNS (3,4-Methylenedioxy-β-nitrostyrene)

MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.

S1652

Monobenzone

Monobenzone is a compound used as a topical agent for medical depigmentation. It can specifically block tyrosinase.

S4132

Deoxyarbutin

DeoxyArbutin is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM.

S6237

2-Ketoglutaric acid

2-Ketoglutaric acid, also known as alpha-ketoglutarate and AKG, is a key molecule in the TCA cycle, playing a fundamental role in determining the overall rate of this important metabolic process. In the TCA cycle, AKG is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase, which functions as a key control point of the TCA cycle. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase.

S4571

Hexylresorcinol

Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, is a potent inhibitor of mushroom tyrosinase. The IC50 values of hexylresorcinol for monophenolase is 1.24 μM and for diphenolase is 0.85 μM.

S6272

Glycolic acid

Glycolic acid (or hydroxyacetic acid) is the smallest alpha-hydroxy acid. Due to its excellent capability to penetrate skin, glycolic acid is often used in skin care products, most often as a chemical peel. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

S2375

Aloin

Aloin, a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.

S2263

Arbutin

Arbutin is a tyrosinase inhibitor with an IC50 of 1.09 mM.

S4739

Oxyresveratrol

Oxyresveratrol, a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.

S9284

Aloesin

Aloesin is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro.

S4997

4-Butylresorcinol

4-Butylresorcinol is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.

S3691

4-Chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid

4-Chlorosalicylic acid was used in sensitive spectrofluorometric determination of terbium in mixed rare earths and preparation of poly(4-chlorosalicylic acid-formaldehyde) via condensation with formaldehyde. 4-Chlorosalicylic acid is a pharmaceutical intermediate. Inhibits monophenolase and diphenolase activity with IC50s of 1.89 mM and 1.10 mM. Potent antimicrobial activity. Against E. coli with the MIC of 250 μg/mL and with the MBC of 500 μg/mL.

S9089

Magnoflorine

Magnoflorine, an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase.

S5174

Kojic acid

Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives.

S9111

Isorhamnetin

Isorhamnetin, a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity.

S9376

Benzylacetone

Benzylacetone is an attractant compound in flowers. Benzylacetone exhibits potent and reversible antityrosinase (mushroom) activity, with IC50s of 2.8 mM and 0.6 mM for monophenolase and diphenolase, respectively.

S6221

Methyl cinnamate

Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.

Catalog No. Information Product Use Citations Product Validations
S3783

Echinacoside

Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions. Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche salsa, elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Echinacoside also has a remarkable antiosteoporotic activity.