MALT
Inhibitory Selectivity
Isoform-specific Inhibitors
MALT Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S8898 |
MLT-748MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state. |
||
| S7429 |
MI-2 (MALT1 inhibitor)MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor with IC50 of 5.84 μM. |
(a-b) Cell growth analysis via MTT assay. Melanoma cell lines, including A2028, A375, WM35, Skmel28, CRL7625 and CRL7626, were seeded in 96-well dishes, and treated in tetrads for 48 hours with varying doses of MI-2. Graph represents average percent of live cells normalized to the untreated group +/- SD.
|
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S8898 |
MLT-748MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state. |
||
| S7429 |
MI-2 (MALT1 inhibitor)MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor with IC50 of 5.84 μM. |
(a-b) Cell growth analysis via MTT assay. Melanoma cell lines, including A2028, A375, WM35, Skmel28, CRL7625 and CRL7626, were seeded in 96-well dishes, and treated in tetrads for 48 hours with varying doses of MI-2. Graph represents average percent of live cells normalized to the untreated group +/- SD.
|
