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MALT

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S7429 MI-2 (MALT1 inhibitor) MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor with IC50 of 5.84 μM.
Cell Mol Gastroenterol Hepatol, 2025, 19(2):101422
Adv Healthc Mater, 2024, e2401192.
J Clin Invest, 2023, 133(3)e165694
Verified customer review of MI-2 (MALT1 inhibitor)
S8898 MLT-748 MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state.
Cell Rep, 2024, 43(1):113631
S9896 Safimaltib Safimaltib(JNJ-67856633,JNJ-6633) is a potent, selective, allosteric inhibitor of MALT1 protease.
Cancer Res Commun, 2024, 4(2):312-327.
E1740 Mepazine hydrochloride Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective inhibitor of MALT1 protease, with IC50 values of 0.83 μM for GSTMALT1 full length and 0.42 μM for GSTMALT1 aa 325-760. It effectively suppresses the activation of the NF-kB pathway specifically in activated B cell subtype of diffuse large B cell lymphoma (ABC-DLBCL) cells and makes it a promising candidate for the treatment of ABC-DLBCL.