Thrombin

Other Proteases Related Inhibitors

Proteasome HCV Protease HIV Protease MMP Cysteine Protease Serine Protease Tyrosinase Glutaminase PAD Neprilysin

Cat.No.	Product Name	Information	Product Use Citations
S1346	Heparin Sodium	Heparin sodium, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins. Heparin is used as an anticoagulant primarily through its interaction with AT III by enhancing AT-IIImediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin prevents the induction of autophagy.	Communications Biology, September 02, 2022, 902 Nature Communications, November 12, 2024, 9771 Stem Cells Translational Medicine, May 27, 2022, 552-565
S2196	Dabigatran	Dabigatran is a potent nonpeptide thrombin inhibitor with an IC50 of 9.3 nM in a cell-free assay.	Frontiers in Cardiovascular Medicine, September 29, 2021, 717835 Stroke, October 2017, 2865-2871 Blood, November 14, 2019, 1764-1775
S2154	Dabigatran (BIBR-1048) etexilate	Dabigatran Etexilate (BIBR-1048) is the prodrug of dabigatran, a potent, nonpeptidic small molecule that specifically and reversibly inhibits both free and clot-bound thrombin by binding to the active site of the thrombin molecule.	J Immunother Cancer, 2024, 12(11)e009805 Eur J Pharmacol, 2024, 985:177058 European Journal of Pharmaceutical Sciences, 2023 Feb 1, 106362
S2069	Argatroban (MCI-9038)	Argatroban (MCI-9038) is a potent and selective synthetic thrombin inhibitor, with K_i ranging from 5 nM to 39 nM, and it is used as an anticoagulant.	Journal of Neuroinflammation, July 16, 2022, 189 Neural Regeneration Research, February 2024, 434-439 Neural Regeneration Research, 2024 Feb, 434-439
S5960	Dabigatran etexilate mesylate	Dabigatran etexilate mesylate (Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate) is an orally active prodrug of Dabigatran which is a reversible and selective, direct thrombin inhibitor (DTI). Dabigatran selectively and reversibly inhibits human thrombin with Ki of 4.5 nM and thrombin-induced platelet aggregation with IC50 of 10 nM.	Redox Biology, 2025, 103721 bioRxiv, 2020, 10.1101/2020.04.22.054981
S5074	Argatroban Monohydrate	Argatroban (Argatroban hydrate, Argipidine,MCI-9038 Monohydrate) is a direct, selective thrombin inhibitor with anticoagulant effects.	Cancer Lett, 2023, 553:215983 Life Sci, 2021, 269:119073
E5835	Heparin	Heparin is a highly sulfated polysaccharide primarily used as an anticoagulant, which works mainly by inhibiting thrombin (FIIa) and/or factor Xa (FXa). It is commonly used to prevent and treat thromboembolic conditions such as deep vein thrombosis and pulmonary embolism. It also plays roles in inflammation, angiogenesis, and growth factor signaling, with potential therapeutic applications in cancer treatment and allergic conditions.