Thrombin

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Catalog No. Product Name Information Product Use Citations Product Validations
S1346 Heparin sodium Heparin sodium, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins. Heparin is used as an anticoagulant primarily through its interaction with AT III by enhancing AT-IIImediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin prevents the induction of autophagy.
J Extracell Vesicles, 2021, 10(8):e12091
Nat Struct Mol Biol, 2021, 10.1038/s41594-020-00537-7
Theranostics, 2021, 11(5):2364-2380
S2069 Argatroban (MCI-9038) Argatroban (MCI-9038) is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM, used as an anticoagulant.
Life Sci, 2021, 269:119073
Nat Metab, 2020, 2(5):447-460
Arthritis Rheumatol, 2018, 70(1):69-79
S2154 Dabigatran (BIBR-1048) etexilate Dabigatran Etexilate (BIBR-1048) is the prodrug of dabigatran, a potent, nonpeptidic small molecule that specifically and reversibly inhibits both free and clot-bound thrombin by binding to the active site of the thrombin molecule.
Sci Rep, 2022, 12(1):3955
Malar J, 2020, 15;19(1):155
Mol Neurobiol, 2018, 55(5):4078-4089
S2196 Dabigatran (BIBR 953) Dabigatran (BIBR 953) is a potent nonpeptide thrombin inhibitor with an IC50 of 9.3 nM in a cell-free assay.
Signal Transduct Target Ther, 2022, 7(1):59
Sci Rep, 2022, 12(1):3955
Int J Biol Macromol, 2021, 184:209-217
S4545 Warfarin Warfarin (Athrombine K, Coumadin, Coumafene, WARF 42, Zoocoumarin) is one of the most widely used anticoagulant drugs worldwide, used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body.
S5074 Argatroban Monohydrate Argatroban (Argatroban hydrate, Argipidine) is a direct, selective thrombin inhibitor with anticoagulant effects.
Life Sci, 2021, 269:119073
S5960 Dabigatran etexilate mesylate Dabigatran etexilate mesylate (Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate) is an orally active prodrug of Dabigatran which is a reversible and selective, direct thrombin inhibitor (DTI). Dabigatran selectively and reversibly inhibits human thrombin with Ki of 4.5 nM and thrombin-induced platelet aggregation with IC50 of 10 nM.
bioRxiv, 2020, 10.1101/2020.04.22.054981
S1346 Heparin sodium Heparin sodium, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins. Heparin is used as an anticoagulant primarily through its interaction with AT III by enhancing AT-IIImediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin prevents the induction of autophagy.
J Extracell Vesicles, 2021, 10(8):e12091
Nat Struct Mol Biol, 2021, 10.1038/s41594-020-00537-7
Theranostics, 2021, 11(5):2364-2380
S2069 Argatroban (MCI-9038) Argatroban (MCI-9038) is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM, used as an anticoagulant.
Life Sci, 2021, 269:119073
Nat Metab, 2020, 2(5):447-460
Arthritis Rheumatol, 2018, 70(1):69-79
S2154 Dabigatran (BIBR-1048) etexilate Dabigatran Etexilate (BIBR-1048) is the prodrug of dabigatran, a potent, nonpeptidic small molecule that specifically and reversibly inhibits both free and clot-bound thrombin by binding to the active site of the thrombin molecule.
Sci Rep, 2022, 12(1):3955
Malar J, 2020, 15;19(1):155
Mol Neurobiol, 2018, 55(5):4078-4089
S2196 Dabigatran (BIBR 953) Dabigatran (BIBR 953) is a potent nonpeptide thrombin inhibitor with an IC50 of 9.3 nM in a cell-free assay.
Signal Transduct Target Ther, 2022, 7(1):59
Sci Rep, 2022, 12(1):3955
Int J Biol Macromol, 2021, 184:209-217
S4545 Warfarin Warfarin (Athrombine K, Coumadin, Coumafene, WARF 42, Zoocoumarin) is one of the most widely used anticoagulant drugs worldwide, used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body.
S5074 Argatroban Monohydrate Argatroban (Argatroban hydrate, Argipidine) is a direct, selective thrombin inhibitor with anticoagulant effects.
Life Sci, 2021, 269:119073
S5960 Dabigatran etexilate mesylate Dabigatran etexilate mesylate (Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate) is an orally active prodrug of Dabigatran which is a reversible and selective, direct thrombin inhibitor (DTI). Dabigatran selectively and reversibly inhibits human thrombin with Ki of 4.5 nM and thrombin-induced platelet aggregation with IC50 of 10 nM.
bioRxiv, 2020, 10.1101/2020.04.22.054981