Cathepsin B

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Cathepsin B Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S1013 Bortezomib (PS-341) Bortezomib (PS-341, Velcade, LDP-341, MLM341, NSC 681239) is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.
Nat Commun, 2022, 13(1):165
Nat Commun, 2022, 13(1):17
J Cell Biol, 2022, 221(1)e202103033
S2847 Cathepsin Inhibitor 1 Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
EMBO J, 2020, 39(1):e102030
Arterioscler Thromb Vasc Biol, 2020, ATVBAHA120315151
bioRxiv, 2019, 10.1101/537753
S4591 Nitroxoline Nitroxoline (8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. Nitroxoline impairs tumor progression in vitro and in vivo by inhibiting cathepsin B activity.
mBio, 2018, 9(5)
bioRxiv, 2018, 10.1101/331785
S7379 E-64 E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM. E-64 induces oxidative stress and apoptosis in Filarial Parasite.
Sci Adv, 2021, 7(3)eabc6364
Cell Chem Biol, 2021, S2451-9456(21)00213-0
Epigenetics Chromatin, 2021, 14(1):23
S7380 Leupeptin Hemisulfate Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.
Elife, 2021, 10e62394
Protein Cell, 2021, 10.1007/s13238-021-00858-3
Front Cell Dev Biol, 2021, 9:670145
S7420 CA-074 methyl ester (CA-074 Me) CA-074 methyl ester (CA-074 Me, Cathepsin B Inhibitor IV) is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor.
Toxicol Lett, 2022, 357:73-83
Adv Sci (Weinh), 2021, e2102666
Autophagy, 2021, 1-20
S3012 Pazopanib Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms/CSF1R with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces cathepsin B activation and autophagy.
Cancer Res, 2021, canres.1222.2021
Cancers (Basel), 2021, 13(14)3635
Radiother Oncol, 2021, 157:175-181
S1013 Bortezomib (PS-341) Bortezomib (PS-341, Velcade, LDP-341, MLM341, NSC 681239) is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.
Nat Commun, 2022, 13(1):165
Nat Commun, 2022, 13(1):17
J Cell Biol, 2022, 221(1)e202103033
S2847 Cathepsin Inhibitor 1 Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
EMBO J, 2020, 39(1):e102030
Arterioscler Thromb Vasc Biol, 2020, ATVBAHA120315151
bioRxiv, 2019, 10.1101/537753
S4591 Nitroxoline Nitroxoline (8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. Nitroxoline impairs tumor progression in vitro and in vivo by inhibiting cathepsin B activity.
mBio, 2018, 9(5)
bioRxiv, 2018, 10.1101/331785
S7379 E-64 E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM. E-64 induces oxidative stress and apoptosis in Filarial Parasite.
Sci Adv, 2021, 7(3)eabc6364
Cell Chem Biol, 2021, S2451-9456(21)00213-0
Epigenetics Chromatin, 2021, 14(1):23
S7380 Leupeptin Hemisulfate Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.
Elife, 2021, 10e62394
Protein Cell, 2021, 10.1007/s13238-021-00858-3
Front Cell Dev Biol, 2021, 9:670145
S7420 CA-074 methyl ester (CA-074 Me) CA-074 methyl ester (CA-074 Me, Cathepsin B Inhibitor IV) is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor.
Toxicol Lett, 2022, 357:73-83
Adv Sci (Weinh), 2021, e2102666
Autophagy, 2021, 1-20
S3012 Pazopanib Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms/CSF1R with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces cathepsin B activation and autophagy.
Cancer Res, 2021, canres.1222.2021
Cancers (Basel), 2021, 13(14)3635
Radiother Oncol, 2021, 157:175-181