Foretinib (GSK1363089)

Catalog No.S1111 Synonyms: EXEL-2880,XL-880

Foretinib (GSK1363089) Chemical Structure

Molecular Weight(MW): 632.65

Foretinib (GSK1363089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.

Size Price Stock Quantity  
In DMSO USD 286 In stock
USD 170 In stock
USD 870 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 34 Publications

Purity & Quality Control

Choose Selective c-Met Inhibitors

Biological Activity

Description Foretinib (GSK1363089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.
Targets
Met [1]
(Cell-free assay)
KDR [1]
(Cell-free assay)
Tie-2 [1]
(Cell-free assay)
VEGFR3/FLT4 [1]
(Cell-free assay)
RON [1]
(Cell-free assay)
0.4 nM 0.86 nM 1.1 nM 2.8 nM 3 nM
In vitro

XL880 inhibits HGF receptor family tyrosine kinases with IC50 values of 0.4 nM for Met and 3 nM for Ron. XL880 also inhibits KDR, Flt-1, and Flt-4 with IC50 values of 0.9 nM, 6.8 nM and 2.8 nM, respectively. XL880 inhibits colony growth of B16F10, A549 and HT29 cells with IC50 of 40 nM, 29 nM and 165 nM, respectively. [1] A recent study indicates XL880 affects cell growth differently in gastric cancer cell lines MKN-45 and KATO-III. XL880 inhibits phosphorylation of MET and downstream signaling molecules in MKN-45 cells, while targets GFGR2 in KATO-III cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Daoy  NHjYPHlHfW6ldHnvckBCe3OjeR?= NWL2V4RGOC53L{GvNk42KM7:TR?= NFrMfGgzPCCq NFSxWFNFVVOR M3TRWYlvcGmkaYTzJJRp\SCKR1[tbY5lfWOnZDDjUWVVKHCjdHj3ZZkh[WO2aY\heIlwdg>? MUmyOVM6OTJ2MR?=
ONS76 M3zNTGZ2dmO2aX;uJGF{e2G7 MnvENE42NzFxMj61JO69VQ>? NYnJeIRVOjRiaB?= M2TmTWROW09? NF34OZRqdmirYnn0d{B1cGViSFfGMYlv\HWlZXSgZ21GXCCyYYToe4F6KGGldHn2ZZRqd25? NGLxTnMzPTN7MUK0NS=>
Daoy  NYH0e|ROTnWwY4Tpc44hSXO|YYm= NITNVVMxNjVxMT:yMlUh|ryP NVzmZWptOjRiaB?= NYrFcmNjTE2VTx?= MWfpcohq[mm2czDIS2YudWWmaXH0[YQhdWmpcnH0bY9vKGGwZDDpcpZie2mxbh?= NWDaN5hFOjV|OUGyOFE>
ONS76 M2XXS2Z2dmO2aX;uJGF{e2G7 M4Hq[|AvPS9zL{KuOUDPxE1? M{HKWlI1KGh? MUnEUXNQ NWD1emtTcW6qaXLpeJMhUEeILX3l[IlifGWmIH3p[5JifGmxbjDhcoQhcW64YYPpc44> NVSzZ4NnOjV|OUGyOFE>
Daoy  MoDYRZBweHSxc3nzJGF{e2G7 MmjjNUDPxE1? NXjXbVAzOjRiaB?= MVHEUXNQ Mn22bY5lfWOnczDhdI9xfG:|aYO= M1rPWFI2OzlzMkSx
Daoy  NHj2bnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrreok5OC53L{GvNk42KM7:TR?= NIT6UI8zPC17NjDo MV;EUXNQ NIq4[lNqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? NXm5TWliOjV|OUGyOFE>
U251 M37vWGZ2dmO2aX;uJGF{e2G7 MlexNVAxNzNyMD:5NFAhdk1? MlnWNUBp MnnWSG1UVw>? NIHW[VZqdmirYnn0d{B1cGVicHjvd5Bpd3K7bHH0bY9vKG:oIF3ldnRMyqB? MYCyOFY2QDN{Nh?=
A172 Mm\zSpVv[3Srb36gRZN{[Xl? NWq5fmloOTByL{OwNE86ODBibl2= M3ewTVEhcA>? M2\FRmROW09? MXfpcohq[mm2czD0bIUheGixc4Doc5J6dGG2aX;uJI9nKE2ncmTLxsA> MVmyOFY2QDN{Nh?=
SF188 M{\LPGZ2dmO2aX;uJGF{e2G7 M3PxSlExOC9|MECvPVAxKG6P NYjXNWhFOSCq NIjjblFFVVOR MknNbY5pcWKrdIOgeIhmKHCqb4PwbI9zgWyjdHnvckBw\iCPZYLUT:Kh MWGyOFY2QDN{Nh?=
U251 MnX3SpVv[3Srb36gRZN{[Xl? NVPFW29tOTByL{OwNE86ODBibl2= MV[xJIg> NHzmbnNFVVOR MYTpcohq[mm2czD0bIUh[WO2aY\peJkhd2ZiQYjsMEBVgXKxMx?= NVTTbWd4OjR4NUizNlY>
A172 NUezdGROTnWwY4Tpc44hSXO|YYm= MonqNVAxNzNyMD:5NFAhdk1? NHXiXmIyKGh? Mn64SG1UVw>? NUnNPZdjcW6qaXLpeJMhfGinIHHjeIl3cXS7IH;mJGF5dCxiVInyc|M> NVXnN3A6OjR4NUizNlY>
SF188 M3TLW2Z2dmO2aX;uJGF{e2G7 NWLXSIRKOTByL{OwNE86ODBibl2= NIjTOoQyKGh? MnLJSG1UVw>? MnjBbY5pcWKrdIOgeIhmKGGldHn2bZR6KG:oIFH4cEwhXHm{b{O= NF7HcHEzPDZ3OEOyOi=>
U251 NEf1OpRHfW6ldHnvckBCe3OjeR?= MVSxNFAwOzByL{mwNEBvVQ>? M{LEVlEhcA>? NISzS3hFVVOR NUK5PIdt\GWlcnXhd4V{KEGtdDDwbI9{eGixconsZZRqd25iaX6gZUBkd26lZX70doF1cW:wIHTldIVv\GWwdDDtZY5v\XJ? M4\wXVI1PjV6M{K2
A172 MnH6SpVv[3Srb36gRZN{[Xl? MX2xNFAwOzByL{mwNEBvVQ>? Ml;TNUBp NWTzOmZyTE2VTx?= MU\k[YNz\WG|ZYOgRYt1KHCqb4PwbI9zgWyjdHnvckBqdiCjIHPvcoNmdnS{YYTpc44h\GWyZX7k[Y51KG2jbn7ldi=> M4nmdFI1PjV6M{K2
SF188 M1PqfWZ2dmO2aX;uJGF{e2G7 MkDCNVAxNzNyMD:5NFAhdk1? NH:ycXIyKGh? MmDGSG1UVw>? NUDtNXo3\GWlcnXhd4V{KEGtdDDwbI9{eGixconsZZRqd25iaX6gZUBkd26lZX70doF1cW:wIHTldIVv\GWwdDDtZY5v\XJ? MV:yOFY2QDN{Nh?=
U251 NHLGOplHfW6ldHnvckBCe3OjeR?= MXexNFAwOzByL{mwNEBvVQ>? Mn3FNlghcA>? NYTjbpNHTE2VTx?= MXfpcoR2[2W|IGDBVnAh[2ynYY\h[4U> NHfUbIwzPDZ3OEOyOi=>
SF188 MlzPSpVv[3Srb36gRZN{[Xl? NWjPO3JJOTByL{OwNE86ODBibl2= NXfaV2ZTOjhiaB?= NHzK[pVFVVOR NUe4fZZ2cW6mdXPld{BRSVKSIHPs[YF3[Wen NUTC[Fk2OjR4NUizNlY>
SF188 NGXCUWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVWxNFAwOzByL{mwNEBvVQ>? Mn\ROFghcA>? MUXEUXNQ M1TLSJJm\HWlZYOgZ4VtdCC|dYL2bZZidCCjdDC5NFAhdk1ic3nncolncWOjboTsfS=> MUeyOFY2QDN{Nh?=
U251 NWrT[WlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjnRZExOTByL{OwNE86ODBibl2= NGPXTWM1QCCq MkTCSG1UVw>? MlfodoVlfWOnczDj[YxtKHO3co\peoFtKGG2IEmwNEBvVSC|aXfubYZq[2GwdHz5 NInMN4UzPDZ3OEOyOi=>
A172 M2nOOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[0dVExOC9|MECvPVAxKG6P NVXhNpRoPDhiaB?= Mmr4SG1UVw>? NEPNZYFz\WS3Y3XzJINmdGxic4Xyeol3[WxiYYSgPVAxKG6PIIPp[45q\mmlYX70cJk> MorxNlQ3PTh|Mk[=
SF188 MmqySpVv[3Srb36gRZN{[Xl? M4XMNVExOC9|MECvPVAxKG6P Mmn3NlQhcA>? MVjEUXNQ MonuZYJzd2ejdHXzJI1q\3KjdHnvckBidmRiaX72ZZNqd25ib3[g[4xqd22jIHPlcIx{KGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVz NELTfYwzPDZ3OEOyOi=>
U251 MYrGeY5kfGmxbjDBd5NigQ>? MVqxNFAwOzByL{mwNEBvVQ>? MlO1NlQhcA>? NXnBNWd4TE2VTx?= NFPz[mJi[nKxZ3H0[ZMhdWmpcnH0bY9vKGGwZDDpcpZie2mxbjDv[kBodGmxbXGgZ4VtdHNiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? NXXTUm03OjR4NUizNlY>
A172 M{DncGZ2dmO2aX;uJGF{e2G7 MXqxNFAwOzByL{mwNEBvVQ>? NFu4XFIzPCCq NFOwWmlFVVOR MYrhZpJw\2G2ZYOgcYloemG2aX;uJIFv\CCrbo\hd4lwdiCxZjDncIlwdWFiY3XscJMhcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZI> M2\2UlI1PjV6M{K2
Ba/F3 MlPLR4VtdCCYaXHibYxqfHliQYPzZZk> NH;wTZMxNjByMEGtNVAh|ryP NHfzR2M4OiCq M1;PRYlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVz NGf3RW0zPDJzOEW4PS=>
HCC78 NXz0NY1lS2WubDDWbYFjcWyrdImgRZN{[Xl? NYH1RnhKOC5yMT2xNEDPxE1? NIfmfFY4OiCq NFjJNZBqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? NVXhfYQ5OjR{MUi1PFk>
SK-HEP1 MYnD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NW[1NIZFOC5{NT2xMlUh|ryP M{HmXVI1yqCq M1HYUYlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVz NUHHPWl1OjJzOEexO|E>
SK-HEP2 MUjGeY5kfGmxbjDBd5NigQ>? NWfvV3BlOSEQvF2= M1;UelI1KGh? M2raOIJtd2OtczDIS2YucW6mdXPl[EBk\WyuIH3veIltcXS7 MYSyNlE5PzF5MR?=
SK-HEP2 MWjGeY5kfGmxbjDBd5NigQ>? NIDkXoQyKM7:TR?= NX7pcIp3OjRiaB?= NV7KUYtP[2G3c3XzJGczN01icHjhd4Uh[XK{ZYP0JJdqfGhicnXkeYN1cW:wIHnuJJRp\SCJMD;HNeKh[W6mIGOgdIhie2W| NInjc3IzOjF6N{G3NS=>
MKN-45  Ml;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkftNE4xOS1zMDFOwG0> M{\XPFUh\A>? NGrFNYFKSzVyPUigcm0> NGrMNpkzOTZ3NUmxPC=>
KATO-III M2fQb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXvWXoxNjBzLUGwJO69VQ>? MWO1JIQ> NFT2O4hKSzVyPUOwJI5O MlzBNlE3PTV7MUi=
MKN-45  NFXPSVNHfW6ldHnvckBCe3OjeR?= MlfwNUDPxE1? NEjVcpkzPCCq NYrxfFN5cW6qaXLpeJMheGixc4Doc5J6dGG2aX;uJI9nKE2HVDygRYt1NCCjbnSgSXJMOS9{IHnuJG1MVi12NR?= M{TtfVIyPjV3OUG4
KATO-III NUK3RWF[TnWwY4Tpc44hSXO|YYm= Mmf3NUDPxE1? MnnLNlQhcA>? MnP4bY5pcWKrdIOgdIhwe3Cqb4L5cIF1cW:wIH;mJG1GXCxiQXv0MEBidmRiRWLLNU8zKGmwIF3LUk01PQ>? MVeyNVY2PTlzOB?=
H1648 MlHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfrTWM2OD1zLkK4JOKyOC5zMjFOwG0> NF\tNY4zOTJ3MkK4OC=>
H1573 M4HLcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjzTWM2OD1zLk[yJOKyKDBwMEWg{txO MWmyNVI2OjJ6NB?=
H596 NF7LVHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHX0eGxKSzVyPUGuNlEhyrFiMD6xO{DPxE1? NEf5UmYzOTJ3MkK4OC=>
HOP92 NYHQXZZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwOEGgxtEhOC5{OTFOwG0> MnPlNlEzPTJ{OES=
H69 NXW3SXR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTFwMUigxtEhOC5yODFOwG0> NHr0OIQzOTJ3MkK4OC=>
H1975 MlrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrOU3YyUUN3ME2xMlM6KMLzIECuN|Mh|ryP M{\PRVIyOjV{Mki0
SCC15 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLMTWM2OD1yLk[zJOKyKDBwMESg{txO M{XQSlIyOjV{Mki0
HN5 NW\rOlFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rSUmlEPTB;MD62OUDDuSByLkK2JO69VQ>? MUGyNVI2OjJ6NB?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-Met / Met / p-Akt / Akt ; 

PubMed: 29854314     


After serum starvation, the cells were treated with vehicle or foretinib for 24 hours. The cell lysates were analyzed by Western blotting using antibodies against p-Met, Met, p-Akt and Akt. Representative examples of bands from Western blots

p-MDM2 / p53 / PUMA ; 

PubMed: 29854314     


After serum starvation, the cells were treated with vehicle or foretinib for 24 hours. The cell lysates were analyzed by Western blotting using antibodies against p-MDM2, p53, PUMA and ACTB. 

pROS1 / tROS1 / pSHP2 / pERK / ERK ; 

PubMed: 24218589     


Immunoblot analysis of FIG-ROS fusion protein phosphorylation and downstream effector modulation after varying doses of crizotinib and foretinib. Cropped images representative of three independent experiments are shown.

29854314 24218589
Growth inhibition assay
Cell viability ; 

PubMed: 29854314     


EC cells were treated with various concentrations of foretinib for 48 hours and then their proliferation was measured by an MTS assay. 

29854314
In vivo A single 100 mg/kg oral gavage dose of XL880 results in substantial inhibition of phosphorylation of B16F10 tumor Met and ligand (e.g., HGFor VEGF)-induced receptor phosphorylation of Met in liver and Flk-1/KDR in lung, which both persisted through 24 hours. Treatment with XL880 (30-100 mg/kg, once daily, oral gavage) results in reduction in tumor burden. The lung surface tumor burden is reduced by 50% and 58% following treatment with 30 and 100 mg/kg XL880, respectively. XL880 treatment of mice bearing B16F10 solid tumors also results in dose-dependent tumor growth inhibition of 64% and 87% at 30 and 100 mg/kg, respectively. For both studies, administration of XL880 is well tolerated with no significant body weight loss. [1] XL880 is developed to target abnormal signaling of HGF through Met and simultaneously target several receptors tyrosine kinase involved in tumor angiogenesis. XL880 caused tumor hemorrhage and necrosis in human xenografts within 2 to 4 hours, and maximal tumornecrosis is observed at 96 hours (after five daily doses), resulting in complete regression. [3]

Protocol

Kinase Assay:

[1]

- Collapse

Kinase Inhibition Assay:

Kinase inhibition is investigated using one of three assay formats: [33P]phosphoryl transfer, luciferase-coupled chemiluminescence, or AlphaScreen tyrosine kinase technology. IC50s are calculated by nonlinear regression analysis using XLFit.33P -Phosphoryl Transfer Kinase Assay Reactions are performed in 384-well white, clear bottom, high-binding microtiter plates (Greiner, Monroe, NC). Plates are coated with 2 μg/well of protein or peptide substrate in a 50 μL volume of coating buffer contained 40 μg/mL substrate (poly(Glu, Tyr) 4:1, 22.5 mM Na2CO3, 27.5 mM NaHCO3, 50 mM NaCl and 3 mM NaN 3. Coated plates are washed once with 50 μL of assay buffer following overnight incubation at room temperature (RT). Test compounds and enzymes are combined with 33P-γ-ATP (3.3 μCi/nmol) in a total volume of 20 μL. The reaction mixture is incubated at RT for 2 hours and terminated by aspiration. The microtiter plates are subsequently washed 6 times with 0.05% Tween-PBS buffer (PBST). Scintillation fluid (50 μL/well) is added and incorporated 33P is measured by liquid scintillation spectrometry using a MicroBeta scintillation counter.Luciferase-Coupled Chemiluminescence Assay Reactions are conducted in 384-well white, medium binding microtiter plates (Greiner). In a first step enzyme and compound are combined and incubated for 60 minutes; reactions are initiated by addition of ATP and peptide substrate (poly(Glu, Tyr) 4:1) in a final voume of 20 μL, and incubated at RT for 2-4 hours. Following the kinase reaction, a 20 μL aliquot of Kinase Glo (Promega, Madison, WI) is added and luminescence signal is measured using a Victor plate reader. Total ATP consumption is limited to 50%. AlphaScreenTM Tyrosine Kinase Assay Donor beads coated with streptavidin and acceptor beads coated with PY100 anti-phosphotyrosine antibody are used. Biotinylated poly(Glu,Tyr) 4:1 is used as the substrate. Substrate phosphorylation is measured by addition of donor/acceptor beads by luminescence following donor-acceptor bead complex formation. Kinase and test compounds are combined and preincubated for 60 minutes, followed by addition of ATP, and biotinylated poly(Glu, Tyr) in a total volume of 20 μL in 384-well white, medium binding microtiter plates (Greiner). Reaction mixtures are incubated for 1 hour at room temperature. Reactions are quenched by addition of 10 μL of 15-30 μg/mL AlphaScreen bead suspension containing 75 mM Hepes, pH 7.4, 300 mM NaCl, 120 mM EDTA, 0.3% BSA and 0.03% Tween-20. After 2-16 hours incubation at room temperature plates are read using an AlphaQuest reader.
Cell Research:

[1]

- Collapse
  • Cell lines: B16F10, A549, and HT29 cells
  • Concentrations: 40 nM
  • Incubation Time: 12 to 14 days
  • Method:

    B16F10, A549, and HT29 cells (1.2× 103 per well) are mixed with soft agar and seeded in a 96-well plate containing 10% FBS and EXEL-2880 over a base agar layer. For normoxic conditions, the plates are incubated (37°C) for 12 to 14 days in 21% oxygen, 5% CO2, and 74% nitrogen, whereas incubation (37 °C) under hypoxic conditions is done in a hypoxia chamber in 1% oxygen, 5% CO2, and 94% nitrogen. The number of colonies is evaluated under each condition following addition of 50% Alamar Blue and fluorescence detection.


    (Only for Reference)
Animal Research:

[1]

- Collapse
  • Animal Models: B16F10 tumor cells (2 × 10 5) are implanted via i.v. tail vein injection into athymic nude mice (NCr or BALB/c) 5 to 8 weeks old
  • Formulation: 0.9% normal saline
  • Dosages: 100 mg/kg
  • Administration: Administered via oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (158.06 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% propylene glycol, 5% Tween 80, 65% D5W
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 632.65
Formula

C34H34F2N4O6

CAS No. 849217-64-7
Storage powder
in solvent
Synonyms EXEL-2880,XL-880

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00920192 Completed Drug: Foretinib Carcinoma Hepatocellular GlaxoSmithKline August 12 2009 Phase 1
NCT00742261 Completed Drug: GSK1363089 Solid Tumours GlaxoSmithKline August 11 2008 Phase 1
NCT00725764 Completed Drug: GSK1363089 (foretinib) Neoplasms Head and Neck GlaxoSmithKline August 27 2007 Phase 2
NCT00725712 Completed Drug: GSK1363089 (formerly XL880) Neoplasms Gastrointestinal Tract GlaxoSmithKline March 31 2007 Phase 2
NCT00743067 Completed Drug: GSK1363089 (formerly XL880) Solid Tumours GlaxoSmithKline August 9 2006 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

c-Met Signaling Pathway Map

c-Met Inhibitors with Unique Features

Related c-Met Products

Tags: buy Foretinib (GSK1363089) | Foretinib (GSK1363089) supplier | purchase Foretinib (GSK1363089) | Foretinib (GSK1363089) cost | Foretinib (GSK1363089) manufacturer | order Foretinib (GSK1363089) | Foretinib (GSK1363089) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID