Foretinib (GSK1363089)

For research use only.

Catalog No.S1111 Synonyms: EXEL-2880,XL-880

53 publications

Foretinib (GSK1363089) Chemical Structure

CAS No. 849217-64-7

Foretinib (GSK1363089, EXEL-2880, XL-880) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 286 In stock
USD 170 In stock
USD 297 In stock
USD 870 In stock
USD 1990 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's Foretinib (GSK1363089) has been cited by 53 publications

Purity & Quality Control

Choose Selective c-Met Inhibitors

Biological Activity

Description Foretinib (GSK1363089, EXEL-2880, XL-880) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.
Targets
Met [1]
(Cell-free assay)
KDR [1]
(Cell-free assay)
Tie-2 [1]
(Cell-free assay)
VEGFR3/FLT4 [1]
(Cell-free assay)
RON [1]
(Cell-free assay)
0.4 nM 0.86 nM 1.1 nM 2.8 nM 3 nM
In vitro

XL880 inhibits HGF receptor family tyrosine kinases with IC50 values of 0.4 nM for Met and 3 nM for Ron. XL880 also inhibits KDR, Flt-1, and Flt-4 with IC50 values of 0.9 nM, 6.8 nM and 2.8 nM, respectively. XL880 inhibits colony growth of B16F10, A549 and HT29 cells with IC50 of 40 nM, 29 nM and 165 nM, respectively. [1] A recent study indicates XL880 affects cell growth differently in gastric cancer cell lines MKN-45 and KATO-III. XL880 inhibits phosphorylation of MET and downstream signaling molecules in MKN-45 cells, while targets GFGR2 in KATO-III cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Daoy  NUnETW5MTnWwY4Tpc44hSXO|YYm= NIjGe3kxNjVxMT:yMlUh|ryP Ml7NNlQhcA>? NWDtb3ROTE2VTx?= NXjJVHRZcW6qaXLpeJMhfGinIFjHSk1qdmS3Y3XkJINOTVRicHH0bJdigSCjY4TpeoF1cW:w MlXPNlU{QTF{NEG=
ONS76 M4TjR2Z2dmO2aX;uJGF{e2G7 M1XlWVAvPS9zL{KuOUDPxE1? NH;0UFYzPCCq M2H6NGROW09? M1jkOYlvcGmkaYTzJJRp\SCKR1[tbY5lfWOnZDDjUWVVKHCjdHj3ZZkh[WO2aY\heIlwdg>? MViyOVM6OTJ2MR?=
Daoy  MofMSpVv[3Srb36gRZN{[Xl? NXHpUIx{OC53L{GvNk42KM7:TR?= MXGyOEBp MkHqSG1UVw>? NYLaXIJ[cW6qaXLpeJMhUEeILX3l[IlifGWmIH3p[5JifGmxbjDhcoQhcW64YYPpc44> M1O3dFI2OzlzMkSx
ONS76 MWTGeY5kfGmxbjDBd5NigQ>? Mn7KNE42NzFxMj61JO69VQ>? NXTFOJRXOjRiaB?= NGTZXFRFVVOR MXPpcohq[mm2czDIS2YudWWmaXH0[YQhdWmpcnH0bY9vKGGwZDDpcpZie2mxbh?= MYGyOVM6OTJ2MR?=
Daoy  NEnZN3VCeG:ydH;zbZMhSXO|YYm= NXXGelNTOSEQvF2= M{jVWlI1KGh? Mnf6SG1UVw>? MXHpcoR2[2W|IHHwc5B1d3Orcx?= NHK2U5ozPTN7MUK0NS=>
Daoy  M3;NNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jSfFAvPS9zL{KuOUDPxE1? M160fFI1NTl4IHi= MnfYSG1UVw>? NXLSc3NwcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? NUnmWXpGOjV|OUGyOFE>
U251 NYjzdm1rTnWwY4Tpc44hSXO|YYm= MlHlNVAxNzNyMD:5NFAhdk1? MnH2NUBp MVPEUXNQ MnXKbY5pcWKrdIOgeIhmKHCqb4PwbI9zgWyjdHnvckBw\iCPZYLUT:Kh NYXUTlNWOjR4NUizNlY>
A172 M{DWOmZ2dmO2aX;uJGF{e2G7 M1PUdVExOC9|MECvPVAxKG6P NXPrS4Z6OSCq MVfEUXNQ NGntbllqdmirYnn0d{B1cGVicHjvd5Bpd3K7bHH0bY9vKG:oIF3ldnRMyqB? NEfUcmIzPDZ3OEOyOi=>
SF188 M1nFOGZ2dmO2aX;uJGF{e2G7 M4jHWlExOC9|MECvPVAxKG6P MXexJIg> Ml7iSG1UVw>? NVXoWHVScW6qaXLpeJMhfGinIIDoc5NxcG:{eXzheIlwdiCxZjDN[ZJVU8Li MVmyOFY2QDN{Nh?=
U251 NIPSVY1HfW6ldHnvckBCe3OjeR?= NFv0c2oyODBxM{CwM|kxOCCwTR?= M4DRUFEhcA>? M1;rTGROW09? Mk\YbY5pcWKrdIOgeIhmKGGldHn2bZR6KG:oIFH4cEwhXHm{b{O= MXmyOFY2QDN{Nh?=
A172 MVTGeY5kfGmxbjDBd5NigQ>? MmTjNVAxNzNyMD:5NFAhdk1? M13pXlEhcA>? MYrEUXNQ M1PnfIlvcGmkaYTzJJRp\SCjY4Tpeol1gSCxZjDBfIwtKFS7cn:z NWG0eIdNOjR4NUizNlY>
SF188 M1npb2Z2dmO2aX;uJGF{e2G7 MXOxNFAwOzByL{mwNEBvVQ>? NESwdnkyKGh? MX7EUXNQ M3TCUolvcGmkaYTzJJRp\SCjY4Tpeol1gSCxZjDBfIwtKFS7cn:z MXOyOFY2QDN{Nh?=
U251 MnzMSpVv[3Srb36gRZN{[Xl? NX3HWpZVOTByL{OwNE86ODBibl2= MonCNUBp MoXYSG1UVw>? MXTk[YNz\WG|ZYOgRYt1KHCqb4PwbI9zgWyjdHnvckBqdiCjIHPvcoNmdnS{YYTpc44h\GWyZX7k[Y51KG2jbn7ldi=> MmGwNlQ3PTh|Mk[=
A172 MmXRSpVv[3Srb36gRZN{[Xl? MmfVNVAxNzNyMD:5NFAhdk1? MXSxJIg> NXXRZ|Z1TE2VTx?= MYHk[YNz\WG|ZYOgRYt1KHCqb4PwbI9zgWyjdHnvckBqdiCjIHPvcoNmdnS{YYTpc44h\GWyZX7k[Y51KG2jbn7ldi=> M4DHeFI1PjV6M{K2
SF188 MYnGeY5kfGmxbjDBd5NigQ>? NH3JcFYyODBxM{CwM|kxOCCwTR?= MWmxJIg> NUfsclFuTE2VTx?= Ml70[IVkemWjc3XzJGFsfCCyaH;zdIhwenmuYYTpc44hcW5iYTDjc45k\W62cnH0bY9vKGSncHXu[IVvfCCvYX7u[ZI> MnTzNlQ3PTh|Mk[=
U251 M{XVU2Z2dmO2aX;uJGF{e2G7 NVfRR3V1OTByL{OwNE86ODBibl2= MXiyPEBp Mo\oSG1UVw>? M{f3bolv\HWlZYOgVGFTWCClbHXheoFo\Q>? NUnOcGNwOjR4NUizNlY>
SF188 MYDGeY5kfGmxbjDBd5NigQ>? NFvWSlIyODBxM{CwM|kxOCCwTR?= MYWyPEBp MXnEUXNQ MUTpcoR2[2W|IGDBVnAh[2ynYY\h[4U> NV3BU3l1OjR4NUizNlY>
SF188 NVXFPYRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPjRm5OOTByL{OwNE86ODBibl2= NFqyTGg1QCCq NV3pZ29STE2VTx?= NE\5[FJz\WS3Y3XzJINmdGxic4Xyeol3[WxiYYSgPVAxKG6PIIPp[45q\mmlYX70cJk> MWOyOFY2QDN{Nh?=
U251 Mli2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDnT3ZSOTByL{OwNE86ODBibl2= M3rT[lQ5KGh? NHPSSpVFVVOR M3HHS5Jm\HWlZYOgZ4VtdCC|dYL2bZZidCCjdDC5NFAhdk1ic3nncolncWOjboTsfS=> M3fEbVI1PjV6M{K2
A172 MmLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7vPYx5OTByL{OwNE86ODBibl2= MUO0PEBp MkTuSG1UVw>? MkDpdoVlfWOnczDj[YxtKHO3co\peoFtKGG2IEmwNEBvVSC|aXfubYZq[2GwdHz5 NF;KbHMzPDZ3OEOyOi=>
SF188 M2HnT2Z2dmO2aX;uJGF{e2G7 M4\CZ|ExOC9|MECvPVAxKG6P MnPINlQhcA>? NHXFOlhFVVOR NES4V5Zi[nKxZ3H0[ZMhdWmpcnH0bY9vKGGwZDDpcpZie2mxbjDv[kBodGmxbXGgZ4VtdHNiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? M1HQTFI1PjV6M{K2
U251 NVXjS4FoTnWwY4Tpc44hSXO|YYm= NVX6eW8yOTByL{OwNE86ODBibl2= MnW2NlQhcA>? Mn\tSG1UVw>? M3TYeYFjem:pYYTld{BucWe{YYTpc44h[W6mIHnueoF{cW:wIH;mJIdtcW:vYTDj[YxteyCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? Mln1NlQ3PTh|Mk[=
A172 Ml71SpVv[3Srb36gRZN{[Xl? NF3pU|gyODBxM{CwM|kxOCCwTR?= NYHWO3VXOjRiaB?= NHLVRWFFVVOR NEHCeIJi[nKxZ3H0[ZMhdWmpcnH0bY9vKGGwZDDpcpZie2mxbjDv[kBodGmxbXGgZ4VtdHNiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? MVeyOFY2QDN{Nh?=
Ba/F3 NG\jNGFE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M3HUS|AvODByMT2xNEDPxE1? NV25T4lwPzJiaB?= MkDJbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZI> M4jVW|I1OjF6NUi5
HCC78 MUfD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NH74R5cxNjBzLUGwJO69VQ>? MWe3NkBp MYnpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uh\GWyZX7k[Y51KG2jbn7ldi=> M1voXlI1OjF6NUi5
SK-HEP1 NHW1XIRE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MWCwMlI2NTFwNTFOwG0> MXSyOOKhcA>? NW\EWXdJcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? MoT4NlIyQDdzN{G=
SK-HEP2 NYnXO5NwTnWwY4Tpc44hSXO|YYm= M{n4SFEh|ryP NHPDSWgzPCCq MmHoZoxw[2u|IFjHSk1qdmS3Y3XkJINmdGxibX;0bYxqfHl? M3P3flIzOTh5MUex
SK-HEP2 Mn:1SpVv[3Srb36gRZN{[Xl? MYOxJO69VQ>? NF3ne3kzPCCq MXPjZZV{\XNiR{KvUUBxcGG|ZTDhdpJme3Rid3n0bEBz\WS3Y4Tpc44hcW5idHjlJGcxN0dzwrDhcoQhWyCyaHHz[ZM> MlznNlIyQDdzN{G=
MKN-45  MoDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1m3b|AvODFvMUCg{txO NH7tSJA2KGR? NYrhdZd2UUN3ME24JI5O NEPOSnMzOTZ3NUmxPC=>
KATO-III NFvuN49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGP2VlcxNjBzLUGwJO69VQ>? M3vzUFUh\A>? Mk\YTWM2OD1|MDDuUS=> M3Pp[lIyPjV3OUG4
MKN-45  NGrYTXNHfW6ldHnvckBCe3OjeR?= NVezRXdjOSEQvF2= MWWyOEBp M1jmXYlvcGmkaYTzJJBpd3OyaH;yfYxifGmxbjDv[kBOTVRuIFHreEwh[W6mIFXST|EwOiCrbjDNT24uPDV? NHzBcWkzOTZ3NUmxPC=>
KATO-III NFz4NGVHfW6ldHnvckBCe3OjeR?= MlP4NUDPxE1? MnLFNlQhcA>? NWPkbohDcW6qaXLpeJMheGixc4Doc5J6dGG2aX;uJI9nKE2HVDygRYt1NCCjbnSgSXJMOS9{IHnuJG1MVi12NR?= MVeyNVY2PTlzOB?=
H1648 NGjsbYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTFwMkigxtExNjF{IN88US=> M{eyUlIyOjV{Mki0
H1573 NXrBUZJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\PSpJKUUN3ME2xMlYzKMLzIECuNFUh|ryP NInkW28zOTJ3MkK4OC=>
H596 NIe1VlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXG0RpFIUUN3ME2xMlIyKMLzIECuNVch|ryP MYCyNVI2OjJ6NB?=
HOP92 NFTLTopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUH4UWhXUUN3ME2wMlgyKMLzIECuNlkh|ryP MWiyNVI2OjJ6NB?=
H69 MorxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTFwMUigxtEhOC5yODFOwG0> M3r4ZlIyOjV{Mki0
H1975 MlTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTFwM{mgxtEhOC5|MzFOwG0> M37GZVIyOjV{Mki0
SCC15 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7qb5VJUUN3ME2wMlY{KMLzIECuNFQh|ryP MVSyNVI2OjJ6NB?=
HN5 MmflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;TN2hNUUN3ME2wMlY2KMLzIECuNlYh|ryP MlvVNlEzPTJ{OES=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-Met / Met / p-Akt / Akt ; 

PubMed: 29854314     


After serum starvation, the cells were treated with vehicle or foretinib for 24 hours. The cell lysates were analyzed by Western blotting using antibodies against p-Met, Met, p-Akt and Akt. Representative examples of bands from Western blots

p-MDM2 / p53 / PUMA ; 

PubMed: 29854314     


After serum starvation, the cells were treated with vehicle or foretinib for 24 hours. The cell lysates were analyzed by Western blotting using antibodies against p-MDM2, p53, PUMA and ACTB. 

pROS1 / tROS1 / pSHP2 / pERK / ERK ; 

PubMed: 24218589     


Immunoblot analysis of FIG-ROS fusion protein phosphorylation and downstream effector modulation after varying doses of crizotinib and foretinib. Cropped images representative of three independent experiments are shown.

29854314 24218589
Growth inhibition assay
Cell viability ; 

PubMed: 29854314     


EC cells were treated with various concentrations of foretinib for 48 hours and then their proliferation was measured by an MTS assay. 

29854314
In vivo A single 100 mg/kg oral gavage dose of XL880 results in substantial inhibition of phosphorylation of B16F10 tumor Met and ligand (e.g., HGFor VEGF)-induced receptor phosphorylation of Met in liver and Flk-1/KDR in lung, which both persisted through 24 hours. Treatment with XL880 (30-100 mg/kg, once daily, oral gavage) results in reduction in tumor burden. The lung surface tumor burden is reduced by 50% and 58% following treatment with 30 and 100 mg/kg XL880, respectively. XL880 treatment of mice bearing B16F10 solid tumors also results in dose-dependent tumor growth inhibition of 64% and 87% at 30 and 100 mg/kg, respectively. For both studies, administration of XL880 is well tolerated with no significant body weight loss. [1] XL880 is developed to target abnormal signaling of HGF through Met and simultaneously target several receptors tyrosine kinase involved in tumor angiogenesis. XL880 caused tumor hemorrhage and necrosis in human xenografts within 2 to 4 hours, and maximal tumornecrosis is observed at 96 hours (after five daily doses), resulting in complete regression. [3]

Protocol

Kinase Assay:

[1]

- Collapse

Kinase Inhibition Assay:

Kinase inhibition is investigated using one of three assay formats: [33P]phosphoryl transfer, luciferase-coupled chemiluminescence, or AlphaScreen tyrosine kinase technology. IC50s are calculated by nonlinear regression analysis using XLFit.33P -Phosphoryl Transfer Kinase Assay Reactions are performed in 384-well white, clear bottom, high-binding microtiter plates (Greiner, Monroe, NC). Plates are coated with 2 μg/well of protein or peptide substrate in a 50 μL volume of coating buffer contained 40 μg/mL substrate (poly(Glu, Tyr) 4:1, 22.5 mM Na2CO3, 27.5 mM NaHCO3, 50 mM NaCl and 3 mM NaN 3. Coated plates are washed once with 50 μL of assay buffer following overnight incubation at room temperature (RT). Test compounds and enzymes are combined with 33P-γ-ATP (3.3 μCi/nmol) in a total volume of 20 μL. The reaction mixture is incubated at RT for 2 hours and terminated by aspiration. The microtiter plates are subsequently washed 6 times with 0.05% Tween-PBS buffer (PBST). Scintillation fluid (50 μL/well) is added and incorporated 33P is measured by liquid scintillation spectrometry using a MicroBeta scintillation counter.Luciferase-Coupled Chemiluminescence Assay Reactions are conducted in 384-well white, medium binding microtiter plates (Greiner). In a first step enzyme and compound are combined and incubated for 60 minutes; reactions are initiated by addition of ATP and peptide substrate (poly(Glu, Tyr) 4:1) in a final voume of 20 μL, and incubated at RT for 2-4 hours. Following the kinase reaction, a 20 μL aliquot of Kinase Glo (Promega, Madison, WI) is added and luminescence signal is measured using a Victor plate reader. Total ATP consumption is limited to 50%. AlphaScreenTM Tyrosine Kinase Assay Donor beads coated with streptavidin and acceptor beads coated with PY100 anti-phosphotyrosine antibody are used. Biotinylated poly(Glu,Tyr) 4:1 is used as the substrate. Substrate phosphorylation is measured by addition of donor/acceptor beads by luminescence following donor-acceptor bead complex formation. Kinase and test compounds are combined and preincubated for 60 minutes, followed by addition of ATP, and biotinylated poly(Glu, Tyr) in a total volume of 20 μL in 384-well white, medium binding microtiter plates (Greiner). Reaction mixtures are incubated for 1 hour at room temperature. Reactions are quenched by addition of 10 μL of 15-30 μg/mL AlphaScreen bead suspension containing 75 mM Hepes, pH 7.4, 300 mM NaCl, 120 mM EDTA, 0.3% BSA and 0.03% Tween-20. After 2-16 hours incubation at room temperature plates are read using an AlphaQuest reader.
Cell Research:

[1]

- Collapse
  • Cell lines: B16F10, A549, and HT29 cells
  • Concentrations: 40 nM
  • Incubation Time: 12 to 14 days
  • Method:

    B16F10, A549, and HT29 cells (1.2× 103 per well) are mixed with soft agar and seeded in a 96-well plate containing 10% FBS and EXEL-2880 over a base agar layer. For normoxic conditions, the plates are incubated (37°C) for 12 to 14 days in 21% oxygen, 5% CO2, and 74% nitrogen, whereas incubation (37 °C) under hypoxic conditions is done in a hypoxia chamber in 1% oxygen, 5% CO2, and 94% nitrogen. The number of colonies is evaluated under each condition following addition of 50% Alamar Blue and fluorescence detection.


    (Only for Reference)
Animal Research:

[1]

- Collapse
  • Animal Models: B16F10 tumor cells (2 × 10 5) are implanted via i.v. tail vein injection into athymic nude mice (NCr or BALB/c) 5 to 8 weeks old
  • Dosages: 100 mg/kg
  • Administration: Administered via oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (158.06 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% propylene glycol, 5% Tween 80, 65% D5W
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 632.65
Formula

C34H34F2N4O6

CAS No. 849217-64-7
Storage powder
in solvent
Synonyms EXEL-2880,XL-880
Smiles COC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00920192 Completed Drug: Foretinib Carcinoma Hepatocellular GlaxoSmithKline August 12 2009 Phase 1
NCT00742261 Completed Drug: GSK1363089 Solid Tumours GlaxoSmithKline August 11 2008 Phase 1
NCT00725764 Completed Drug: GSK1363089 (foretinib) Neoplasms Head and Neck GlaxoSmithKline August 27 2007 Phase 2
NCT00725712 Completed Drug: GSK1363089 (formerly XL880) Neoplasms Gastrointestinal Tract GlaxoSmithKline March 31 2007 Phase 2
NCT00743067 Completed Drug: GSK1363089 (formerly XL880) Solid Tumours GlaxoSmithKline August 9 2006 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

c-Met Signaling Pathway Map

c-Met Inhibitors with Unique Features

Related c-Met Products

Tags: buy Foretinib (GSK1363089) | Foretinib (GSK1363089) supplier | purchase Foretinib (GSK1363089) | Foretinib (GSK1363089) cost | Foretinib (GSK1363089) manufacturer | order Foretinib (GSK1363089) | Foretinib (GSK1363089) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID