E0142New |
XL092
|
XL092 (JUN04542) is an ATP-competitive inhibitor of multiple RTKs including MET, VEGFR2, AXL and MER, with IC50 values of 15 nM, 1.6 nM, 3.4 nM, and 7.2 nM in cell-based assays, respectively.
|
|
|
S0361 |
AMG-1
|
AMG-1 (c-Met/RON Dual Kinase Inhibitor, RON-IN-1) is a potent inhibitor of human c-Met and RON with IC50 of 4 nM and 9 nM, respectively. |
|
|
S0540 |
BAY-474
|
BAY-474 is an inhibitor of tyrosine-protein kinase c-Met and can act as an epigenetics probe. |
|
|
S1068 |
Crizotinib (PF-02341066)
|
Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines. |
-
Cancer Cell, 2022, S1535-6108(21)00662-0
-
NPJ Precis Oncol, 2022, 6(1):5
-
Eur J Cancer, 2022, 170:91-102
|
|
S1070 |
PHA-665752
|
PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM in cell-free assays, >50-fold selectivity for c-Met than RTKs or STKs. |
-
Cancers (Basel), 2022, 14(6)1512
-
J Mol Med (Berl), 2022, 10.1007/s00109-022-02179-2
-
PLoS One, 2022, 17(3):e0264907
|
|
S1080 |
SU11274
|
SU11274 (PKI-SU11274) is a selective Met (c-Met) inhibitor with IC50 of 10 nM in cell-free assays, no effects on PGDFRβ, EGFR or Tie2. SU11274 induces autophagy, apoptosis and cell cycle arrest. |
-
Front Cell Dev Biol, 2022, 10:836179
-
Cell Rep, 2021, 37(5):109905
-
Int J Mol Sci, 2021, 22(24)13483
|
|
S1094 |
PF-04217903
|
PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM in A549 cell line, susceptible to oncogenic mutations (no activity to Y1230C mutant). Phase 1. |
-
Cell Chem Biol, 2019, 10.1016/j.chembiol.2019.06.003
-
Neoplasia, 2019, 22(1):1-9
-
Sci Rep, 2019, 9(1):606
|
|
S1111 |
Foretinib (GSK1363089)
|
Foretinib (GSK1363089, EXEL-2880, XL-880, GSK089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met (c-Met) and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit (c-Kit), PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2. |
-
Int J Mol Sci, 2022, 23(2)775
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
Cell Rep Med, 2022, 3(1):100492
|
|
S1112 |
SGX-523
|
SGX-523 is a selective Met (c-Met) inhibitor with IC50 of 4 nM, no activity to BRAFV599E, c-Raf, Abl and p38α. Phase 1. |
-
Cell Cycle, 2022, 1-15
-
J Pathol, 2020, 250(2):205-216
-
Acta Pharmacol Sin, 2020, 10.1038/s41401-019-0336-3
|
|
S1114 |
JNJ-38877605
|
JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases. Phase 1. |
-
NPJ Precis Oncol, 2022, 6(1):11
-
Cancers (Basel), 2021, 13(17)4309
-
Cancers (Basel), 2021, 13(19)5012
|
|
S1119 |
Cabozantinib (BMS-907351)
|
Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway. |
-
Adv Sci (Weinh), 2022, e2201478
-
Cancer Res, 2022, canres.1397.2021
-
Biomaterials, 2022, 283:121454
|
|
S1124 |
BMS-754807
|
BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met (c-Met), Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2. |
-
Front Oncol, 2021, 11:650052
-
Life Sci, 2021, 267:118977
-
Sci China Life Sci, 2021, 10.1007/s11427-020-1836-7
|
|
S1244 |
Amuvatinib (MP-470)
|
Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2. |
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
mBio, 2021, 12(6):e0322821
-
Hum Cell, 2021, 34(6):1911-1918
|
|
S1316 |
AMG-208
|
AMG 208 is a highly selective dual c-Met and RON inhibitor with IC50 of 9 nM for c-Met. |
|
|
S1361 |
MGCD-265 analog
|
MGCD-265 is a potent, multi-target and ATP-competitive inhibitor of c-Met and VEGFR1/2/3 with IC50 of 1 nM, 3 nM/3 nM/4 nM, respectively; also inhibits Ron and Tie2. Phase 1/2. |
-
Cell Rep Med, 2022, 3(1):100492
-
Elife, 2019, 8e47460
-
Protein Cell, 2019, 10(3):161-177
|
|
S1561 |
BMS-777607
|
BMS-777607 (BMS 817378) is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM in cell-free assays, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases. Phase 1/2. |
-
Cancers (Basel), 2022, 14(10)2493
-
J Biol Chem, 2022, S0021-9258(22)00469-0
-
Elife, 2021, 10e63678
|
|
S2201 |
BMS-794833
|
BMS-794833 is a potent ATP competitive inhibitor of Met (c-Met)/VEGFR2 with IC50 of 1.7 nM/15 nM, also inhibits Ron, Axl and Flt3 with IC50 of <3 nM; a prodrug of BMS-817378. Phase 1. |
-
Cancer Res, 2021, canres.1428.2021
|
|
S2747 |
AMG-458
|
AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells. |
|
|
S2753 |
Tivantinib (ARQ 197)
|
Tivantinib (ARQ 197) is the first non-ATP-competitive c-Met inhibitor with Ki of 0.355 μM in a cell-free assay, little activity to Ron, and no inhibition to EGFR, InsR, PDGFRα or FGFR1/4. Tivantinib (ARQ 197) induces a G2/M arrest and apoptosis. Phase 3. |
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
Cell Rep Med, 2022, 3(1):100492
-
Signal Transduct Target Ther, 2021, 6(1):401
|
|
S2761 |
NVP-BVU972
|
NVP-BVU972 is a selective and potent Met (c-Met) inhibitor with IC50 of 14 nM. |
-
PLoS Biol, 2021, 19(5):e3001263
|
|
S2774 |
MK-2461
|
MK-2461 is a potent, multi-targeted inhibitor for c-Met(WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1; 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB. Phase 1/2. |
-
Mol Carcinog, 2021, 60(7):481-496
-
G3 (Bethesda), 2021, 11(10)jkab265
-
Mol Cell Biochem, 2018, 449(1-2):1-8
|
|
S2788 |
Capmatinib (INCB28060)
|
Capmatinib (INCB28060, INC280, NVP-INC280) is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. Capmatinib (INCB28060) inhibits Wnt/β-catenin and EMT signaling pathways and induces apoptosis in diffuse gastric cancer positive for c-MET amplification. Phase 1. |
-
Cell Rep, 2022, 39(1):110608
-
PLoS Pathog, 2022, 18(1):e1010247
-
Cancers (Basel), 2022, 14(8)2005
|
|
S2859 |
Golvatinib (E7050)
|
Golvatinib (E7050) is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM, does not inhibit bFGF-stimulated HUVEC growth (up to 1000 nM). Phase 1/2. |
-
Cancer Sci, 2020, 111(10):3813-3823
-
Nephron, 2020, 1-12
-
Cell, 2019, 178(6):1478-1492
|
|
S3759 |
Norcantharidin
|
Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers. |
|
|
S4001 |
Cabozantinib malate
|
Cabozantinib malate (XL184) is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret (c-Ret), Kit (c-Kit), Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib malate (XL184) induces apoptosis. |
-
Adv Sci (Weinh), 2022, e2201478
-
Cancer Res, 2022, canres.1397.2021
-
Cancers (Basel), 2022, 14(7)1683
|
|
S5190 |
Crizotinib hydrochloride
|
Crizotinib (PF-02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c-Met and nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell-based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines. |
-
NPJ Precis Oncol, 2022, 6(1):5
-
Cell Death Dis, 2022, 13(4):351
-
Cancers (Basel), 2022, 14(6)1378
|
|
S6412 |
Altiratinib
|
Altiratinib (DCC-2701) is a potent single-digit nanomolar inhibitor of TRK, Met (c-Met), TIE2, and VEGFR2 kinases with IC50 vaules of 0.9 nM, 4.6 nM, and 0.8 nM for TRKA, B, and C, respectively. It inhibits Met (c-Met) and Met (c-Met) mutant with IC50 values in the range of 0.3-6 nM. |
-
Theranostics, 2021, 11(20):9918-9936
-
Cold Spring Harb Mol Case Stud, 2021, 7(5)a006109
|
|
S6762 |
Bozitinib (PLB-1001)
|
Bozitinib (PLB-1001, CBT-101, APL-101, CBI-3103) is a highly selective ATP-competitive c-Met inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) selectively inhibits MET-altered tumor cells in preclinical models. |
|
|
S6764New |
Pamufetinib (TAS-115)
|
Pamufetinib (TAS-115) is a highly potent c-Met and VEGFR dual inhibitor with IC50s of 30 nM and 32 nM for recombinant VEGFR2 and recombinant MET, respectively. |
|
|
S6870 |
Ningetinib
|
Ningetinib (CT-053, DE-120, CT053PTSA) is a potent, orally bioavailable inhibitor of tyrosine kinase with IC50 of 6.7 nM, 1.9 nM and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. Ningetinib exhibits antitumor activity. |
|
|
S6899 |
Licochalcone D
|
Licochalcone D (Lico D, LCD, LD), a flavonoid isolated from a Chinese medicinal plant Glycyrrhiza inflata, has antioxidant, anti-inflammatory and anti-cancer properties. Licochalcone D inhibit phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone D inhibits JAK2, EGFR and Met (c-Met) activities and induces ROS-dependent apoptosis. Licochalcone D also induces caspases activation and poly (ADP-ribose) polymerase (PARP) cleavage. |
|
|
S7014 |
Merestinib (LY2801653)
|
Merestinib (LY2801653) is a type-II ATP competitive, slow-off inhibitor of Met (c-Met) tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min(-1) and t1/2 of 525 min. Merestinib (LY2801653) also inhibits MST1R, AXL, ROS1, MKNK1/2, FLT3, MERTK, DDR1 and DDR2 with IC50 of 11 nM, 2 nM, 23 nM, 7 nM, 7 nM, 10 nM, 0.1 nM and 7 nM, respectively. |
-
J Clin Invest, 2021, 131(11)146987
-
Mol Cancer Ther, 2021, molcanther.0344.2021
-
Front Oncol, 2020, 12;10:700
|
|
S7564 |
SAR125844
|
SAR125844 is a potent intravenously active and highly selective Met (c-Met) kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively). |
|
|
S7669 |
NPS-1034
|
NPS-1034 is a dual Met (c-Met)/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively. |
-
J Med Chem, 2021, 64(6):3165-3184
-
Sci Rep, 2021, 11(1):19667
|
|
S7674 |
Savolitinib (AZD6094)
|
Savolitinib (Volitinib, AZD6094, HMPL-504) is a novel, potent, and selective MET inhibitor currently in clinical development in various indications, including PRCC. The IC50 values of this compound for c-Met and p-Met are 5 nM and 3 nM, respectively. It shows exquisite selectivity for c-Met over 274 kinase. |
-
Mol Cancer Ther, 2021, molcanther.0344.2021
-
Phytomedicine, 2021, 80:153355
-
J Exp Clin Cancer Res, 2021, 40(1):69
|
|
S8167 |
AMG 337
|
AMG 337 is an oral, small molecule, ATP-competitive, highly selective inhibitor of the Met (c-Met) receptor with an IC50 of 1 nM. |
-
J Biol Chem, 2022, S0021-9258(22)00070-9
-
Cancer Cell, 2019, 36(1):35-50
|
|
S8404 |
S49076
|
S49076 is a novel, potent inhibitor of Met (c-Met), AXL/MER, and FGFR1/2/3 with IC50 values below 20 nmol/L. |
-
Mol Brain, 2020, 4;13(1):66
|
|
S8570 |
RXDX-106 (CEP-40783)
|
RXDX-106 (CEP-40783) is an orally-available, potent and selective TAM(TYRO3, AXL, MER)/Met (c-Met) inhibitor displaying low nanomolar biochemical activity and slow (T1/2 >120 min) inhibitor off-rate in peptide phosphorylation assays and in vitro kinase binding assays, respectively. |
-
J Oncol, 2022, 2022:2946929
-
Clin Cancer Res, 2021, 27(9):2533-2548
-
Cell Rep, 2021, 37(1):109789
|
|
S8676 |
Glumetinib (SCC244)
|
Glumetinib (SCC244) is a potent and highly selective c-Met inhibitor with an IC50 of 0.42 ± 0.02 nmol/L. Glumetinib has greater than 2,400-fold selectivity for c-Met over those 312 kinases evaluated, including the c-Met family member RON and highly homologous kinases Axl, Mer, and TyrO3. |
|
|
S8854 |
JNJ-38877618(OMO-1)
|
JNJ-38877618 (OMO-1) is a potent, highly selective, orally bioavailable Met (c-Met) kinase inhibitor with binding affinity (Kd) of 1.4 nM and enzyme inhibitory activity against wt and M1268T mutant Met (c-Met) (2 and 3 nM IC50). |
|
|
S9308 |
Pulsatilla saponin D
|
Pulsatilla saponin D (SB365), isolated from the root of Pulsatilla koreana, targets c-Met and exerts antiangiogenic and antitumor activities. |
|
|
S9620New |
Elzovantinib (TPX-0022)
|
Elzovantinib (TPX-0022, CSF1R-IN-2) is a potent inhibitor of MET/CSF1R/SRC with enzymatic kinase inhibition IC50s of 0.14 nM, 0.71 nM and 0.12 nM, respectively. TPX-0022 modulates the tumor immune microenvironment in preclinical models. |
|
|
S9662 |
UNC2025
|
UNC2025 is a potent and orally active dual inhibitor of FLT3 and MER with IC50 of 0.35 nM and 0.46 nM, respectively. UNC2025 also inhibits AXL, TRKA, TRKC, QIK, TYRO3, SLK, NuaK1, Kit (c-Kit) and Met (c-Met) with IC50 of 1.65 nM, 1.67 nM, 4.38 nM, 5.75 nM, 5.83 nM, 6.14 nM, 7.97 nM, 8.18 nM and 364 nM, respectively. |
-
JCI Insight, 2022, 7(7)e154824
-
Front Immunol, 2020, 11:564133
-
Cell Signal, 2014, 26(1):149-61
|
|
S5115 |
Sodium L-ascorbyl-2-phosphate
|
Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products. It is used in skin care recipes for UV protection, collagen production, as an antioxidant and for its skin lightening and brightening effects. Sodium L-ascorbyl-2-phosphate (2-Phospho-L-ascorbic acid trisodium salt, L-Ascorbic acid 2-phosphate trisodium salt, Sodium ascorbyl phosphate, SAP) is a selective antioxidant and a stimulator of hepatocyte growth factor (HGF) production. |
-
Stem Cell Res Ther, 2021, 12(1):48
|
|
E0142New |
XL092
|
XL092 (JUN04542) is an ATP-competitive inhibitor of multiple RTKs including MET, VEGFR2, AXL and MER, with IC50 values of 15 nM, 1.6 nM, 3.4 nM, and 7.2 nM in cell-based assays, respectively.
|
|
|
S0361 |
AMG-1
|
AMG-1 (c-Met/RON Dual Kinase Inhibitor, RON-IN-1) is a potent inhibitor of human c-Met and RON with IC50 of 4 nM and 9 nM, respectively. |
|
|
S0540 |
BAY-474
|
BAY-474 is an inhibitor of tyrosine-protein kinase c-Met and can act as an epigenetics probe. |
|
|
S1068 |
Crizotinib (PF-02341066)
|
Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines. |
- Cancer Cell, 2022, S1535-6108(21)00662-0
- NPJ Precis Oncol, 2022, 6(1):5
- Eur J Cancer, 2022, 170:91-102
|
|
S1070 |
PHA-665752
|
PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM in cell-free assays, >50-fold selectivity for c-Met than RTKs or STKs. |
- Cancers (Basel), 2022, 14(6)1512
- J Mol Med (Berl), 2022, 10.1007/s00109-022-02179-2
- PLoS One, 2022, 17(3):e0264907
|
|
S1080 |
SU11274
|
SU11274 (PKI-SU11274) is a selective Met (c-Met) inhibitor with IC50 of 10 nM in cell-free assays, no effects on PGDFRβ, EGFR or Tie2. SU11274 induces autophagy, apoptosis and cell cycle arrest. |
- Front Cell Dev Biol, 2022, 10:836179
- Cell Rep, 2021, 37(5):109905
- Int J Mol Sci, 2021, 22(24)13483
|
|
S1094 |
PF-04217903
|
PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM in A549 cell line, susceptible to oncogenic mutations (no activity to Y1230C mutant). Phase 1. |
- Cell Chem Biol, 2019, 10.1016/j.chembiol.2019.06.003
- Neoplasia, 2019, 22(1):1-9
- Sci Rep, 2019, 9(1):606
|
|
S1111 |
Foretinib (GSK1363089)
|
Foretinib (GSK1363089, EXEL-2880, XL-880, GSK089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met (c-Met) and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit (c-Kit), PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2. |
- Int J Mol Sci, 2022, 23(2)775
- Hum Cell, 2022, 10.1007/s13577-022-00671-y
- Cell Rep Med, 2022, 3(1):100492
|
|
S1112 |
SGX-523
|
SGX-523 is a selective Met (c-Met) inhibitor with IC50 of 4 nM, no activity to BRAFV599E, c-Raf, Abl and p38α. Phase 1. |
- Cell Cycle, 2022, 1-15
- J Pathol, 2020, 250(2):205-216
- Acta Pharmacol Sin, 2020, 10.1038/s41401-019-0336-3
|
3.">
|
S1114 |
JNJ-38877605
|
JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases. Phase 1. |
- NPJ Precis Oncol, 2022, 6(1):11
- Cancers (Basel), 2021, 13(17)4309
- Cancers (Basel), 2021, 13(19)5012
|
|
S1119 |
Cabozantinib (BMS-907351)
|
Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway. |
- Adv Sci (Weinh), 2022, e2201478
- Cancer Res, 2022, canres.1397.2021
- Biomaterials, 2022, 283:121454
|
|
S1124 |
BMS-754807
|
BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met (c-Met), Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2. |
- Front Oncol, 2021, 11:650052
- Life Sci, 2021, 267:118977
- Sci China Life Sci, 2021, 10.1007/s11427-020-1836-7
|
|
S1244 |
Amuvatinib (MP-470)
|
Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2. |
- Hum Cell, 2022, 10.1007/s13577-022-00671-y
- mBio, 2021, 12(6):e0322821
- Hum Cell, 2021, 34(6):1911-1918
|
|
S1316 |
AMG-208
|
AMG 208 is a highly selective dual c-Met and RON inhibitor with IC50 of 9 nM for c-Met. |
|
|
S1361 |
MGCD-265 analog
|
MGCD-265 is a potent, multi-target and ATP-competitive inhibitor of c-Met and VEGFR1/2/3 with IC50 of 1 nM, 3 nM/3 nM/4 nM, respectively; also inhibits Ron and Tie2. Phase 1/2. |
- Cell Rep Med, 2022, 3(1):100492
- Elife, 2019, 8e47460
- Protein Cell, 2019, 10(3):161-177
|
|
S1561 |
BMS-777607
|
BMS-777607 (BMS 817378) is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM in cell-free assays, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases. Phase 1/2. |
- Cancers (Basel), 2022, 14(10)2493
- J Biol Chem, 2022, S0021-9258(22)00469-0
- Elife, 2021, 10e63678
|
|
S2201 |
BMS-794833
|
BMS-794833 is a potent ATP competitive inhibitor of Met (c-Met)/VEGFR2 with IC50 of 1.7 nM/15 nM, also inhibits Ron, Axl and Flt3 with IC50 of <3 nM; a prodrug of BMS-817378. Phase 1. |
- Cancer Res, 2021, canres.1428.2021
|
|
S2747 |
AMG-458
|
AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells. |
|
|
S2753 |
Tivantinib (ARQ 197)
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Tivantinib (ARQ 197) is the first non-ATP-competitive c-Met inhibitor with Ki of 0.355 μM in a cell-free assay, little activity to Ron, and no inhibition to EGFR, InsR, PDGFRα or FGFR1/4. Tivantinib (ARQ 197) induces a G2/M arrest and apoptosis. Phase 3. |
- Hum Cell, 2022, 10.1007/s13577-022-00671-y
- Cell Rep Med, 2022, 3(1):100492
- Signal Transduct Target Ther, 2021, 6(1):401
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S2761 |
NVP-BVU972
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NVP-BVU972 is a selective and potent Met (c-Met) inhibitor with IC50 of 14 nM. |
- PLoS Biol, 2021, 19(5):e3001263
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S2774 |
MK-2461
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MK-2461 is a potent, multi-targeted inhibitor for c-Met(WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1; 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB. Phase 1/2. |
- Mol Carcinog, 2021, 60(7):481-496
- G3 (Bethesda), 2021, 11(10)jkab265
- Mol Cell Biochem, 2018, 449(1-2):1-8
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S2788 |
Capmatinib (INCB28060)
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Capmatinib (INCB28060, INC280, NVP-INC280) is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. Capmatinib (INCB28060) inhibits Wnt/β-catenin and EMT signaling pathways and induces apoptosis in diffuse gastric cancer positive for c-MET amplification. Phase 1. |
- Cell Rep, 2022, 39(1):110608
- PLoS Pathog, 2022, 18(1):e1010247
- Cancers (Basel), 2022, 14(8)2005
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S2859 |
Golvatinib (E7050)
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Golvatinib (E7050) is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM, does not inhibit bFGF-stimulated HUVEC growth (up to 1000 nM). Phase 1/2. |
- Cancer Sci, 2020, 111(10):3813-3823
- Nephron, 2020, 1-12
- Cell, 2019, 178(6):1478-1492
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S3759 |
Norcantharidin
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Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers. |
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S4001 |
Cabozantinib malate
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Cabozantinib malate (XL184) is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret (c-Ret), Kit (c-Kit), Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib malate (XL184) induces apoptosis. |
- Adv Sci (Weinh), 2022, e2201478
- Cancer Res, 2022, canres.1397.2021
- Cancers (Basel), 2022, 14(7)1683
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S5190 |
Crizotinib hydrochloride
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Crizotinib (PF-02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c-Met and nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell-based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines. |
- NPJ Precis Oncol, 2022, 6(1):5
- Cell Death Dis, 2022, 13(4):351
- Cancers (Basel), 2022, 14(6)1378
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S6412 |
Altiratinib
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Altiratinib (DCC-2701) is a potent single-digit nanomolar inhibitor of TRK, Met (c-Met), TIE2, and VEGFR2 kinases with IC50 vaules of 0.9 nM, 4.6 nM, and 0.8 nM for TRKA, B, and C, respectively. It inhibits Met (c-Met) and Met (c-Met) mutant with IC50 values in the range of 0.3-6 nM. |
- Theranostics, 2021, 11(20):9918-9936
- Cold Spring Harb Mol Case Stud, 2021, 7(5)a006109
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S6762 |
Bozitinib (PLB-1001)
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Bozitinib (PLB-1001, CBT-101, APL-101, CBI-3103) is a highly selective ATP-competitive c-Met inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) selectively inhibits MET-altered tumor cells in preclinical models. |
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S6764New |
Pamufetinib (TAS-115)
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Pamufetinib (TAS-115) is a highly potent c-Met and VEGFR dual inhibitor with IC50s of 30 nM and 32 nM for recombinant VEGFR2 and recombinant MET, respectively. |
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S6870 |
Ningetinib
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Ningetinib (CT-053, DE-120, CT053PTSA) is a potent, orally bioavailable inhibitor of tyrosine kinase with IC50 of 6.7 nM, 1.9 nM and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. Ningetinib exhibits antitumor activity. |
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S6899 |
Licochalcone D
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Licochalcone D (Lico D, LCD, LD), a flavonoid isolated from a Chinese medicinal plant Glycyrrhiza inflata, has antioxidant, anti-inflammatory and anti-cancer properties. Licochalcone D inhibit phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone D inhibits JAK2, EGFR and Met (c-Met) activities and induces ROS-dependent apoptosis. Licochalcone D also induces caspases activation and poly (ADP-ribose) polymerase (PARP) cleavage. |
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S7014 |
Merestinib (LY2801653)
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Merestinib (LY2801653) is a type-II ATP competitive, slow-off inhibitor of Met (c-Met) tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min(-1) and t1/2 of 525 min. Merestinib (LY2801653) also inhibits MST1R, AXL, ROS1, MKNK1/2, FLT3, MERTK, DDR1 and DDR2 with IC50 of 11 nM, 2 nM, 23 nM, 7 nM, 7 nM, 10 nM, 0.1 nM and 7 nM, respectively. |
- J Clin Invest, 2021, 131(11)146987
- Mol Cancer Ther, 2021, molcanther.0344.2021
- Front Oncol, 2020, 12;10:700
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S7564 |
SAR125844
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SAR125844 is a potent intravenously active and highly selective Met (c-Met) kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively). |
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S7669 |
NPS-1034
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NPS-1034 is a dual Met (c-Met)/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively. |
- J Med Chem, 2021, 64(6):3165-3184
- Sci Rep, 2021, 11(1):19667
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S7674 |
Savolitinib (AZD6094)
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Savolitinib (Volitinib, AZD6094, HMPL-504) is a novel, potent, and selective MET inhibitor currently in clinical development in various indications, including PRCC. The IC50 values of this compound for c-Met and p-Met are 5 nM and 3 nM, respectively. It shows exquisite selectivity for c-Met over 274 kinase. |
- Mol Cancer Ther, 2021, molcanther.0344.2021
- Phytomedicine, 2021, 80:153355
- J Exp Clin Cancer Res, 2021, 40(1):69
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S8167 |
AMG 337
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AMG 337 is an oral, small molecule, ATP-competitive, highly selective inhibitor of the Met (c-Met) receptor with an IC50 of 1 nM. |
- J Biol Chem, 2022, S0021-9258(22)00070-9
- Cancer Cell, 2019, 36(1):35-50
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S8404 |
S49076
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S49076 is a novel, potent inhibitor of Met (c-Met), AXL/MER, and FGFR1/2/3 with IC50 values below 20 nmol/L. |
- Mol Brain, 2020, 4;13(1):66
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S8570 |
RXDX-106 (CEP-40783)
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RXDX-106 (CEP-40783) is an orally-available, potent and selective TAM(TYRO3, AXL, MER)/Met (c-Met) inhibitor displaying low nanomolar biochemical activity and slow (T1/2 >120 min) inhibitor off-rate in peptide phosphorylation assays and in vitro kinase binding assays, respectively. |
- J Oncol, 2022, 2022:2946929
- Clin Cancer Res, 2021, 27(9):2533-2548
- Cell Rep, 2021, 37(1):109789
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S8676 |
Glumetinib (SCC244)
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Glumetinib (SCC244) is a potent and highly selective c-Met inhibitor with an IC50 of 0.42 ± 0.02 nmol/L. Glumetinib has greater than 2,400-fold selectivity for c-Met over those 312 kinases evaluated, including the c-Met family member RON and highly homologous kinases Axl, Mer, and TyrO3. |
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S8854 |
JNJ-38877618(OMO-1)
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JNJ-38877618 (OMO-1) is a potent, highly selective, orally bioavailable Met (c-Met) kinase inhibitor with binding affinity (Kd) of 1.4 nM and enzyme inhibitory activity against wt and M1268T mutant Met (c-Met) (2 and 3 nM IC50). |
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S9308 |
Pulsatilla saponin D
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Pulsatilla saponin D (SB365), isolated from the root of Pulsatilla koreana, targets c-Met and exerts antiangiogenic and antitumor activities. |
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S9620New |
Elzovantinib (TPX-0022)
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Elzovantinib (TPX-0022, CSF1R-IN-2) is a potent inhibitor of MET/CSF1R/SRC with enzymatic kinase inhibition IC50s of 0.14 nM, 0.71 nM and 0.12 nM, respectively. TPX-0022 modulates the tumor immune microenvironment in preclinical models. |
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S9662 |
UNC2025
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UNC2025 is a potent and orally active dual inhibitor of FLT3 and MER with IC50 of 0.35 nM and 0.46 nM, respectively. UNC2025 also inhibits AXL, TRKA, TRKC, QIK, TYRO3, SLK, NuaK1, Kit (c-Kit) and Met (c-Met) with IC50 of 1.65 nM, 1.67 nM, 4.38 nM, 5.75 nM, 5.83 nM, 6.14 nM, 7.97 nM, 8.18 nM and 364 nM, respectively. |
- JCI Insight, 2022, 7(7)e154824
- Front Immunol, 2020, 11:564133
- Cell Signal, 2014, 26(1):149-61
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