Ephrin Receptor Signalling | Ephrin Receptor Inhibitor Review

Catalog No.	Product Name	Information	Product Use Citations
S0256	Ehp-inhibitor-1	Ehp-inhibitor-1 (Ehp inhibitor 2) is an Eph family tyrosine kinase inhibitor that targets Eph receptors.
S2202	NVP-BHG712	NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively.	Cell Rep, 2021, 35(1):108940 Mol Ther Nucleic Acids, 2021, 25:328-341 Cancer Lett, 2020, 475:53-64
S6515	ALW II-41-27	ALW II-41-27 (compound 7) is a potent inhibitor of Eph receptor tyrosine kinase with Kd of 12 nM for EphA2.
S8573	Sitravatinib (MGCD516)	Sitravatinib (MGCD516, MG-516) is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl.	Cancers (Basel), 2021, 13(21)5474 Cancers (Basel), 2020, 12(1)
S0256	Ehp-inhibitor-1	Ehp-inhibitor-1 (Ehp inhibitor 2) is an Eph family tyrosine kinase inhibitor that targets Eph receptors.
S2202	NVP-BHG712	NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively.	Cell Rep, 2021, 35(1):108940 Mol Ther Nucleic Acids, 2021, 25:328-341 Cancer Lett, 2020, 475:53-64
S6515	ALW II-41-27	ALW II-41-27 (compound 7) is a potent inhibitor of Eph receptor tyrosine kinase with Kd of 12 nM for EphA2.
S8573	Sitravatinib (MGCD516)	Sitravatinib (MGCD516, MG-516) is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl.	Cancers (Basel), 2021, 13(21)5474 Cancers (Basel), 2020, 12(1)

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