Home Biosimilar Antibodies Protein Tyrosine Kinase c-Met Rilotumumab (Anti-HGF / SF)
For research use only. Not for use in humans.

Rilotumumab (Anti-HGF / SF)

Synonyms: AMG 102

Rilotumumab (Anti-HGF / SF) is a monoclonal antibody that inhibits HGF/MET-driven signaling. Rilotumumab shows anti-tumor activity, and can be used in castration-resistant prostate cancer (CRPC) and solid tumor research. MW: 145.5 KD.

Rilotumumab (Anti-HGF / SF)

Quality Control

Batch: A246901 Purity: 99% Protein concentration: 14.86mg/ml Endotoxin Level: ＜1EU/mg
99

Specificity

Name Citation c-Met Others
Foretinib (GSK1363089, XL880) 94 KDR,Tie-2,VEGFR3/FLT4
PHA-665752 96 RON,Flk1
SU11274 67
SGX-523 137
BMS-777607 63 Axl,RON,Tyro3
Tivantinib 49
JNJ-38877605 55
PF-04217903 22
MGCD-265 analog 14 RON,VEGFR1,VEGFR2
BMS-754807 54 Insulin Receptor,IGF-1R,TrkB
BMS-794833 4 VEGFR2
AMG-208 2
MK-2461 5 c-Met (Y1235D),c-Met (Y1230C),c-Met (N1100)
Golvatinib (E7050) 8 VEGFR2
AMG-458 0
Tepotinib (EMD-1214063) 23
NVP-BVU972 1
XL092 0 VEGFR2,AXL,MER
UNC2025 7 FLT3,Mer,Axl
Ningetinib 0 Axl,VEGFR2
Elzovantinib (TPX-0022) 0 SRC,CSF1R
AMG-1 0 RON
Pamufetinib (TAS-115) 0 recombinant VEGFR2
JNJ-38877618(OMO-1) 0 MET (M1268T)
Altiratinib 3 MET Y1230C,TrkA,TrkC
SAR125844 0 MET Y1235D,MET M1250T,TRKA/NTRK1
Glumetinib 2
Savolitinib (AZD6094) 20 p-Met
CEP-40783 (RXDX-106) 7 Axl,Tyro3,MER
S49076 1 Mer,Axl,FGFR3
Merestinib (LY2801653) 11 DDR1,AXL,FLT3
AMG 337 2
NPS-1034 6 Axl
Amuvatinib (MP-470) 22 c-RET,RAD51,c-Kit (D816H)
Glesatinib 2 SMO
Terevalefim 1
Licochalcone D 1 Caspase,EGFR,JAK2
BAY-474 0
Bozitinib 1
Pulsatilla saponin D 1
Sodium L-Ascorbyl-2-Phosphate (SAP) 3
Norcantharidin 5 EGFR
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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Rilotumumab (Anti-HGF / SF) is a monoclonal antibody that inhibits HGF/MET-driven signaling. Rilotumumab shows anti-tumor activity, and can be used in castration-resistant prostate cancer (CRPC) and solid tumor research. MW: 145.5 KD.

Product Details

CAS No. 872514-65-3
Molecular Weight 145.5 kDa
Isotype Human IgG2SA
Source CHO
Purification AKTA
Sterility 0.2 μM filtered
Formulation 100 mM Pro-Ac, 20mM Arg, pH5.0
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT07757815 NOT_YET_RECRUITING Depression, Postpartum University of Macau 2026-09-01
NCT06689865 RECRUITING Hearing Loss; Hearing Aids; OTC Hearing Aids University of Colorado, Denver 2024-11-13
NCT06945042 RECRUITING Acute Myeloid Leukemia Wake Forest University Health Sciences 2025-06-27
NCT07727057 RECRUITING Arrhythmias, Cardiac Biosense Webster, Inc. 2026-07-08
NCT07658690 NOT_YET_RECRUITING Drug: 38% Silver Fluoride (Riva Star Aqua) Dentine Caries University of Malaya 2026-10 PHASE3
NCT07074028 RECRUITING Sepsis; Myopathy Critical Illness Centre Hospitalier de Saint-Brieuc 2025-03-25

(data from https://clinicaltrials.gov, updated on 2026-08-11)

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