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Pyk2

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Cat.No. Product Name Information Product Use Citations Product Validations
S2890 PF-562271 (VS-6062) PF-562271 (PF-00562271) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
Cell Death Differ, 2025, 10.1038/s41418-025-01469-9
Front Oncol, 2025, 15:1498005
Cell Rep, 2024, 43(12):114992
Verified customer review of PF-562271 (VS-6062)
S8032 PRT062607 (P505-15) HCl PRT062607 (P505-15, BIIB057, PRT-2607) HCl is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, PAK5, Lyn, FAK, Pyk2, FLT3, MLK1 and Zap70.
Sci Adv, 2025, 11(31):eadu4270
Sci Rep, 2024, 14(1):7739
J Exp Med, 2023, 220(9)e20230054
Verified customer review of PRT062607 (P505-15) HCl
S7357 PF-562271 HCl PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
Nat Cardiovasc Res, 2023, 2(6):550-571
Front Immunol, 2022, 13:837180
Cancers (Basel), 2022, 14(6)1537
Verified customer review of PF-562271 HCl
S2672 PF-562271 Besylate PF-562271 Besylate is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
JCI Insight, 2025, 10(13)e187684
Elife, 2023, 12RP89141
bioRxiv, 2023, 2023.06.02.543509
Verified customer review of PF-562271 Besylate
S2820 TAE226 (NVP-TAE226) TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. This compound induces apoptosis.
Exp Ther Med, 2025, 29(5):93
Theranostics, 2022, 12(3):1097-1116
Proc Natl Acad Sci U S A, 2022, 119(32):e2201328119
Verified customer review of TAE226 (NVP-TAE226)
S7644 PF-431396 PF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11 nM and 2 nM, respectively.
bioRxiv, 2025, 2025.07.31.668026
Cytojournal, 2024, 21:34
Nat Commun, 2023, 14(1):6270
E1961 NVL-655 (Neladalkib) NVL-655 is a selective inhibitor of anaplastic lymphoma kinase (ALK), with potential antineoplastic activity in the Ba/F3 xenograft model. It also exhibits significant inhibitory activity against ROS1, LTK, PYK2, TRKB, and FAK, with an IC50 ≤10-fold ALK and demonstrates high potency against specific ALK mutations, with an IC50 of <0.73 nM, 7 nM, 3 nM, 3 nM for G1202R, G1202R/L1196M, G1202R/G1269A and G1202R/L1198F respectively.
Pharm Res, 2025, 42(9):1497-1509
E1783 Conteltinib(CT-707) Conteltinib (CT-707), a potent multikinase inhibitor of ALK, FAK, and Pyk2, shows promising anti-tumor activities. It exhibits significant inhibitory effects on FAK with an IC50 value of 1.6 nM in vitro kinase assay.