Pyk2

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Pyk2 Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S2672 PF-00562271 Besylate PF-00562271 Besylate (PF-562271) is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
Front Immunol, 2022, 13:837180
Cancers (Basel), 2022, 14(6)1537
J Biol Chem, 2022, S0021-9258(22)00119-3
S2820 TAE226 (NVP-TAE226) TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. TAE226 (NVP-TAE226) induces apoptosis.
Theranostics, 2022, 12(3):1097-1116
Cancer Cell, 2021, S1535-6108(21)00492-X
Nat Commun, 2021, 12(1):3519
S2890 PF-562271 PF-562271 (PF-00562271) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
Front Immunol, 2022, 13:837180
Cancers (Basel), 2022, 14(6)1537
J Biol Chem, 2022, S0021-9258(22)00119-3
S7357 PF-562271 HCl PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
Front Immunol, 2022, 13:837180
Cancers (Basel), 2022, 14(6)1537
J Biol Chem, 2022, S0021-9258(22)00119-3
S7644 PF-431396 PF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11 nM and 2 nM, respectively.
J Exp Clin Cancer Res, 2021, 40(1):364
Cancers (Basel), 2021, 13(24)6344
Nat Commun, 2020, 11(1):3282
S8032 PRT062607 (P505-15) HCl PRT062607 (P505-15, BIIB057, PRT-2607) HCl is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, PAK5, Lyn, FAK, Pyk2, FLT3, MLK1 and Zap70.
Cell Rep, 2022, 38(8):110414
Mol Cell, 2021, S1097-2765(21)00264-1
Sci Signal, 2021, 14(682)eabc1648
S2672 PF-00562271 Besylate PF-00562271 Besylate (PF-562271) is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
Front Immunol, 2022, 13:837180
Cancers (Basel), 2022, 14(6)1537
J Biol Chem, 2022, S0021-9258(22)00119-3
S2820 TAE226 (NVP-TAE226) TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. TAE226 (NVP-TAE226) induces apoptosis.
Theranostics, 2022, 12(3):1097-1116
Cancer Cell, 2021, S1535-6108(21)00492-X
Nat Commun, 2021, 12(1):3519
S2890 PF-562271 PF-562271 (PF-00562271) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
Front Immunol, 2022, 13:837180
Cancers (Basel), 2022, 14(6)1537
J Biol Chem, 2022, S0021-9258(22)00119-3
S7357 PF-562271 HCl PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
Front Immunol, 2022, 13:837180
Cancers (Basel), 2022, 14(6)1537
J Biol Chem, 2022, S0021-9258(22)00119-3
S7644 PF-431396 PF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11 nM and 2 nM, respectively.
J Exp Clin Cancer Res, 2021, 40(1):364
Cancers (Basel), 2021, 13(24)6344
Nat Commun, 2020, 11(1):3282
S8032 PRT062607 (P505-15) HCl PRT062607 (P505-15, BIIB057, PRT-2607) HCl is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, PAK5, Lyn, FAK, Pyk2, FLT3, MLK1 and Zap70.
Cell Rep, 2022, 38(8):110414
Mol Cell, 2021, S1097-2765(21)00264-1
Sci Signal, 2021, 14(682)eabc1648
Tags: Pyk2 inhibitor|Pyk2 agonist|Pyk2 activator|Pyk2 inducer|Pyk2 antagonist|Pyk2 signaling pathway|Pyk2 assay kit