Pyk2

Choose Selective Pyk2 Inhibitors

Pyk2 Products

  • All (6)
  • Pyk2 Inhibitors (6)
  • New Pyk2 Products
Catalog No. Product Name Information Product Use Citations Product Validations
S2672 PF-00562271 Besylate PF-00562271 Besylate (PF-562271) is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
Sci Adv, 2021, 7(40):eabh0363
J Nanobiotechnology, 2021, 19(1):175
Cells, 2021, 10(3)663
S2820 TAE226 (NVP-TAE226) TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. TAE226 (NVP-TAE226) induces apoptosis.
Cancer Cell, 2021, S1535-6108(21)00492-X
Nat Commun, 2021, 12(1):3519
mBio, 2021, 12(4):e0149421
S2890 PF-562271 PF-562271 (PF-00562271) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
Sci Adv, 2021, 7(40):eabh0363
Elife, 2021, 10e63093
mBio, 2021, 12(6):e0322821
S7357 PF-562271 HCl PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
Sci Adv, 2021, 7(40):eabh0363
Elife, 2021, 10e63093
J Nanobiotechnology, 2021, 19(1):175
S7644 PF-431396 PF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11 nM and 2 nM, respectively.
J Exp Clin Cancer Res, 2021, 40(1):364
Cancers (Basel), 2021, 13(24)6344
Nat Commun, 2020, 11(1):3282
S8032 PRT062607 (P505-15) HCl PRT062607 (P505-15, BIIB057, PRT-2607) HCl is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, PAK5, Lyn, FAK, Pyk2, FLT3, MLK1 and Zap70.
Mol Cell, 2021, S1097-2765(21)00264-1
Sci Signal, 2021, 14(682)eabc1648
Biochem Pharmacol, 2021, S0006-2952(21)00185-4
S2672 PF-00562271 Besylate PF-00562271 Besylate (PF-562271) is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
Sci Adv, 2021, 7(40):eabh0363
J Nanobiotechnology, 2021, 19(1):175
Cells, 2021, 10(3)663
S2820 TAE226 (NVP-TAE226) TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. TAE226 (NVP-TAE226) induces apoptosis.
Cancer Cell, 2021, S1535-6108(21)00492-X
Nat Commun, 2021, 12(1):3519
mBio, 2021, 12(4):e0149421
S2890 PF-562271 PF-562271 (PF-00562271) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
Sci Adv, 2021, 7(40):eabh0363
Elife, 2021, 10e63093
mBio, 2021, 12(6):e0322821
S7357 PF-562271 HCl PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
Sci Adv, 2021, 7(40):eabh0363
Elife, 2021, 10e63093
J Nanobiotechnology, 2021, 19(1):175
S7644 PF-431396 PF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11 nM and 2 nM, respectively.
J Exp Clin Cancer Res, 2021, 40(1):364
Cancers (Basel), 2021, 13(24)6344
Nat Commun, 2020, 11(1):3282
S8032 PRT062607 (P505-15) HCl PRT062607 (P505-15, BIIB057, PRT-2607) HCl is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, PAK5, Lyn, FAK, Pyk2, FLT3, MLK1 and Zap70.
Mol Cell, 2021, S1097-2765(21)00264-1
Sci Signal, 2021, 14(682)eabc1648
Biochem Pharmacol, 2021, S0006-2952(21)00185-4