Home Protein Tyrosine Kinase DDR

DDR

Other Protein Tyrosine Kinase Related Inhibitors

VEGFR EGFR c-Met PDGFR CSF-1R IGF-1R c-Kit ALK Tie-2 HER2

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S7498 DDR1-IN-1 DDR1-IN-1 is a potent and selective discoidin domain receptor 1 (DDR1) receptor tyrosine kinase inhibitor with IC50 of 105 nM, about 3-fold selectivity over DDR2.
Cell Genom, 2024, 4(2):100487
Biomater Sci, 2022, 10.1039/d2bm00543c
EMBO Mol Med, 2021, e11814
Verified customer review of DDR1-IN-1
E1825 7rh 7rh (DDR1-IN-2) is a potent inhibitor of discoidin domain receptor 1 (DDR1) with an IC50 of 13.1 nM. It also inhibits DDR2 less effectively with an IC50 of 203 nM. It also exhibits antitumor effects in nasopharyngeal carcinoma cells.
S6817 VU6015929 VU6015929 is a selective Discoidin Domain Receptor 1/2 (DDR1/2) inhibitor with IC50 of 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively. This compound potently inhibits collagen-IV production.
S7014 Merestinib (LY2801653) Merestinib (LY2801653) is a type-II ATP competitive, slow-off inhibitor of Met (c-Met) tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min(-1) and t1/2 of 525 min. This compound also inhibits MST1R, AXL, ROS1, MKNK1/2, FLT3, MERTK, DDR1 and DDR2 with IC50 of 11 nM, 2 nM, 23 nM, 7 nM, 7 nM, 10 nM, 0.1 nM and 7 nM, respectively.
Mol Oncol, 2025, 19(8):2366-2387
NPJ Breast Cancer, 2024, 10(1):65
Cancers (Basel), 2024, 16(12)2253
E0621 FGFR1/DDR2 inhibitor 1 FGFR1/DDR2 inhibitor 1 is an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoidin domain receptor 2 (DDR2).