Potassium Channel

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1658 Dofetilide <1 mg/mL 88 mg/mL <1 mg/mL
S2456 Chlorpromazine HCl 71 mg/mL 71 mg/mL 71 mg/mL
S1979 Amiodarone HCl <1 mg/mL 23 mg/mL 11 mg/mL
S1344 Glimepiride <1 mg/mL 11 mg/mL <1 mg/mL
S1160 TRAM-34 <1 mg/mL 0.4 mg/mL <1 mg/mL
S9251 Oxypeucedanin -1 mg/mL 24 mg/mL -1 mg/mL
S9223 Talatisamine -1 mg/mL 35 mg/mL -1 mg/mL
S5028 4-Aminopyridine -1 mg/mL 18 mg/mL -1 mg/mL
S1426 Repaglinide <1 mg/mL 91 mg/mL 91 mg/mL
S2502 Quinine HCl Dihydrate 43 mg/mL 79 mg/mL 79 mg/mL
S1716 Glyburide (Glibenclamide) <1 mg/mL 99 mg/mL <1 mg/mL
S2443 Tolbutamide <1 mg/mL 54 mg/mL 54 mg/mL
S2114 Dronedarone HCl <1 mg/mL 80 mg/mL 40 mg/mL
S2489 Nateglinide <1 mg/mL 63 mg/mL 63 mg/mL
S8016 Vonoprazan Fumarate (TAK-438) <1 mg/mL 62 mg/mL <1 mg/mL
S2825 ML133 HCl <1 mg/mL 63 mg/mL 6 mg/mL
S2601 Gliclazide <1 mg/mL 65 mg/mL <1 mg/mL
S4037 Doxapram HCl 25 mg/mL 87 mg/mL 2 mg/mL
S2073 Mitiglinide Calcium <1 mg/mL <1 mg/mL 2 mg/mL
S1971 Nicorandil 17 mg/mL 42 mg/mL 42 mg/mL
S2562 Hydralazine HCl 1 mg/mL <1 mg/mL <1 mg/mL
S4630 Diazoxide <1 mg/mL 46 mg/mL <1 mg/mL
S4733 Retigabine <1 mg/mL 60 mg/mL 35 mg/mL
S4632 Hexachlorophene <1 mg/mL 81 mg/mL 81 mg/mL
S4734 Retigabine 2HCl 75 mg/mL 75 mg/mL 25 mg/mL
S3151 Gliquidone <1 mg/mL 105 mg/mL 6 mg/mL
Catalog No. Information Product Use Citations Product Validations


Dofetilide is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug.


Chlorpromazine HCl

Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.


Amiodarone HCl

Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.



Glimepiride is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus.



TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450.



Oxypeucedanin is a major coumarin aglycone that can be extracted from Ostericum koreanum. It is a kind of open-channel blocker of the hKv1.5 channel.



Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is a newly identified K+ channel blocker with hypotensive and antiarrhythmic activities.



4-Aminopyridine (4-AP) is a potent and non-selective inhibitor of voltage gated potassium channels (Kv) with IC50 values of 170 μM and 230 μM for Kv1.1 and Kv1.2 in CHO cells, respectively.



Repaglinide is a potassium channel blocker, which lowers blood glucose by stimulating the release of insulin from the pancreas, used the treatment of type II diabetes.


Quinine HCl Dihydrate

Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.


Glyburide (Glibenclamide)

Glyburide (Glibenclamide) is a known blocker of vascular ATP-sensitive K+ channels (KATP), used in the treatment of type 2 diabetes.



Tolbutamide is an inhibitor of potassium channel, used for type II diabetes.


Dronedarone HCl

Dronedarone HCl is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).



Nateglinide is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas.


Vonoprazan Fumarate (TAK-438)

Vonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. Phase 3.


ML133 HCl

ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.



Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.


Doxapram HCl

Doxapram HCl inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.


Mitiglinide Calcium

Mitiglinide Calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.



Nicorandil is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).


Hydralazine HCl

Hydralazine HCl is a hydrochloride salt of hydralazine, which is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles.



Diazoxide is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.



Retigabine(free base) is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels.



Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; It can also attenuate Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.


Retigabine 2HCl

Retigabine is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels.



Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.