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Potassium Channel

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Potassium Channel Signaling Pathway Map

Potassium Channel Products

All (72)
Potassium Channel Inhibitors (50)
Potassium Channel Activators (16)
Potassium Channel Antagonists (2)
Potassium Channel Agonist (1)
Potassium Channel Modulators (2)
New Potassium Channel Products

Catalog No.	Product Name	Information	Product Use Citations
E0001	DCPIB	DCPIB is a specific and potent inhibitor of volume-regulated anion channels (VRAC). DCPIB potently inhibits several K2P channels with no voltage dependence, including TRESK, TASK1, and TASK3. DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM, demonstrating at least 100-fold higher affinity over TREK1/TRAAK channels. DCPIB is also a novel selective blocker of I(Cl,swell), which blocks native I(Cl,swell) of calf bovine pulmonary artery endothelial (CPAE) cells with an IC(50) of 4.1 μM.
E0012	1-EBIO	1-EBIO (1-Ethylbenzimidazolinone, 1-Ethyl-2-benzimidazolinone）is an activator of Ca2+-sensitive K+ channels with an EC50 of 490 µM in T84 cells.
E0015	Iberiotoxin	Iberiotoxin (IbTX) is a toxin purified from the scorpion Buthus tamulus. Iberiotoxin is a potent blocker of the large conductance Ca(2+)-activated K+ channel with a Kd of ~1 nM.
E0144	Vernakalant (RSD1235) Hydrochloride	Vernakalant (RSD-1235, MK-6621) is a novel, frequency-dependent Na+ channel and early activating K+ channel blocker that selectively prolongs the atrial refractory period.
E0501^New	Senicapoc (ICA-17043)	Senicapoc (ICA-17043) is a Gardos channel(Ca2⁺-activated K⁺ channel; KCa3.1) blocker with an IC50 of 11 nM and produces dose-dependent increases in hemoglobin and decreases in markers of hemolysis. Senicapoc blocks Ca2⁺-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM.
S0087	JNJ 303	JNJ 303 is a potent blocker of the voltage dependent I_Ks-channel encoded by KCNQ1/KCNE1 with IC50 of 64 nM. JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP).
S0090	NS6180	NS-6180 is a highly selective inhibitor of KCa3.1 ion channel with IC50 value of 9 nM, which inhibits T cell activation and inflammation.
S0188	GSK369796 Dihydrochloride	GSK369796 Dihydrochloride (N-tert-butylisoquine) is an inhibitor of hERG potassium ion channel repolarization with IC50 of 7.5 μM. GSK369796 Dihydrochloride is an affordable and effective 4-aminoquinoline antimalarial.
S0398	Astemizole	Astemizole (R 43512) is a histamine H1-receptor antagonist with IC50 of 4.7 nM. Astemizole is also a potent inhibitor of ether à-go-go 1 (Eag1) and Eag-related gene (Erg) potassium channels. Astemizole has antineoplastic and antipruritic effects.
S0476	SCH-23390 hydrochloride	SCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390) is a highly potent and selective dopamine D1-like receptor antagonist with Ki of 0.2 nM and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. SCH-23390 hydrochloride is a potent and high efficacy agonist at h5-HT2C receptors with Ki of 9.3 nM. SCH-23390 hydrochloride directly inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with IC50 of 268 nM.
S0524	A2793	A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is an efficient inhibitor of TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK.
S0741	A2764 dihydrochloride	A2764 dihydrochloride is a selective inhibitor of TRESK (TWIK-related spinal cord K+ channel, K2P18.1) with IC50 of 11.8 μM for the activated mTRESK channel. A2764 dihydrochloride has the potential for probing the role of TRESK channel in migraine and nociception.
S1160	TRAM-34	TRAM-34 (Triarylmethane-34) is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with K_d of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450.	Cell Mol Immunol, 2022, 19(8):925-943 Diabetes Res Clin Pract, 2022, S0168-8227(22)00588-5 Am J Cancer Res, 2020, 10(10):3302-3315
S1344	Glimepiride	Glimepiride(HOE-490) is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus.	Sci Rep, 2017, 7(1):3156
S1426	Repaglinide	Repaglinide (AG-EE 623 ZW) is a potassium channel blocker, which lowers blood glucose by stimulating the release of insulin from the pancreas, used the treatment of type II diabetes.	Drug Metab Dispos, 2019, ;47(3):215-226
S1658	Dofetilide	Dofetilide (UK-68798) is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug.	PLoS Pathog, 2020, 16;16(3):e1008341 Toxicol In Vitro, 2020, 104928 Clin Transl Sci, 2019, 12(6):687-697
S1715	Glipizide	Glipizide (CP-28720,K 4024) is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes.
S1716	Glyburide (Glibenclamide)	Glyburide (Glibenclamide) is a known blocker of vascular ATP-sensitive K+ channels (KATP), used in the treatment of type 2 diabetes.	BMC Vet Res, 2022, 18(1):145 PLoS Negl Trop Dis, 2021, 15(4):e0009304 Front Cell Infect Microbiol, 2021, 11:691445
S1979	Amiodarone (NSC 85442) HCl	Amiodarone (NSC 85442,Amiodar,Amiodarone hydrochloride,Nexterone) HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.	Cell Mol Immunol, 2022, 19(8):925-943 Cell Rep, 2022, 38(10):110468 Front Cell Infect Microbiol, 2021, 11:630812
S2073	Mitiglinide Calcium	Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.
S2114	Dronedarone HCl	Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).	Chem Res Toxicol, 2021, 10.1021/acs.chemrestox.1c00127 Cell Syst, 2019, 8(2):97-108 Nat Commun, 2016, 7:13023
S2405	Sophocarpine	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.	Int J Biol Sci, 2019, 15(11):2497-2508 Front Pharmacol, 2019, 10:1219 J Med Virol, 2019, 91(8):1440-1447
S2443	Tolbutamide (HLS 831)	Tolbutamide (HLS 831) is an inhibitor of potassium channel, used for type II diabetes.	Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918 Hum Cell, 2021, 10.1007/s13577-021-00639-4
S2456	Chlorpromazine HCl	Chlorpromazine HCl (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.	Cell Mol Immunol, 2022, 19(8):925-943 PLoS Pathog, 2022, 18(6):e1010620 Emerg Microbes Infect, 2022, 11(1):1135-1144
S2489	Nateglinide	Nateglinide (Starlix,A-4166,SDZ DJN 608) is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas.	Cell Syst, 2019, 8(2):97-108 Nature, 2018, 560(7718):372-376
S2502	Quinine HCl Dihydrate	Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.	J Pharmacol Toxicol Methods, 2017, 90:39-47
S2601	Gliclazide	Gliclazide(S1702, SE1702) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.	IET Syst Biol, 2021, 10.1049/syb2.12034
S2825	ML133 HCl	ML133 HCl is a selective potassium channel inhibitor for K_ir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on K_ir1.1 and weak activity for K_ir4.1 and K_ir7.1.	Nat Commun, 2022, 13(1):3544 Cell Mol Immunol, 2022, 19(8):925-943 Mol Pain, 2019, 15:1744806919838947
S2967	XE991 dihydrochloride	XE 991 (LS190926) dihydrochloride is a blocker of Kv7 (KCNQ) channels that potently inhibits KCNQ1 (Kv7.1), KCNQ2 (Kv7.2), KCNQ2 + KCNQ3 (Kv7.3) channel, and M-current with IC50 of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively.
S3242	Loureirin B	Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the K_ATP current, influx of Ca²⁺ to the intracellular.
S4037	Doxapram HCl	Doxapram HCl inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.
S4186	Domiphen Bromide	Domiphen bromide (NSC-39415) is a quaternary ammonium antiseptic with actions as a cationic surfactant.
S4353	Terfenadine	Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.
S4439	Almitrine mesylate	Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. Almitrine mesylate inhibits the activity of Ca²⁺-dependent K⁺ channel by decreasing its open probability with IC50 of 0.22 μM.
S4489	Tetraethylammonium chloride	Tetraethylammonium (TEA) chloride is a nonspecific potassium channel blocker with antitumor properties.
S4495	Quinine	Quinine, an alkaloid derived from the bark of the cinchona tree, is an anti-malaria agent and a potassium channel inhibitor that inhibits mSlo3 (KCa 5.1) channel currents evoked by voltage pulses to +100 mV with IC50 of 169 μM.	Cell Mol Immunol, 2022, 19(8):925-943 J Pharmacol Toxicol Methods, 2017, 90:39-47
S4583	Butamben	Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.
S4681	Quinidine hydrochloride monohydrate	Quinidine hydrochloride monohydrate is an anti-arrythmic agent and a potent potassium channel inhibitor with IC50 of 19.9 μM.	J Biomed Res, 2021, 35(5):395-407
S5028	4-Aminopyridine	4-Aminopyridine (4-AP, Fampridine, Dalfampridine) is a potent and non-selective inhibitor of voltage gated potassium channels (Kv) with IC50 values of 170 μM and 230 μM for Kv1.1 and Kv1.2 in CHO cells, respectively.
S5257	Doxapram	Doxapram is a central respiratory stimulant with a brief duration of action. Doxapram is a selective TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel inhibitor with EC50 of 410 nM, 37 μM, 9 μM, respectively.	Biomed Chromatogr, 2018, 32(10)
S5371	Ajmaline	Ajmaline (Cardiorythmine, Tachmalin), found in the root of Rauwolfia serpentina, is a class Ia antiarrhythmic agent.
S5749	Chlorpromazine	Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.	ACS Appl Mater Interfaces, 2022, 14(21):24144-24159 Pharmaceuticals (Basel), 2022, 15(2)241 Bioorg Chem, 2022, 127:106008
S5773	NS1643	NS1643 is one of the small molecule HERG (Kv11.1) channel activators and has also been found to increase erg2 (Kv11.2) currents.
S6174	NS8593 Hydrochloride	NS8593 is a potent negative gating inhibitor of small conductance Ca²⁺ -activated K⁺ channels (SK1-3 or Kca2.1-2.3 channels). NS8593 is also a potent inhibitor of the TRPM7 channel with an IC50 of 1.6 µM.
S6284	Tetraethylammonium bromide	Tetraethylammonium bromide (TEAB, TEA bromide) is used as the source of tetraethylammonium ions in pharmacological and physiological studies, but is also used in organic chemical synthesis. It blocks selective potassium channels.
S6554	ML365	ML365 is a novel selective small molecule inhibitor of the TASK1 or potassium channel, subfamily K, member 9 (KCNK3).
S6627	E-4031 dihydrochloride	E-4031 is an experimental class III antiarrhythmic drug that blocks potassium channels of the hERG-type.
S8016	Vonoprazan Fumarate (TAK-438)	Vonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. Phase 3.
S9223	Talatisamine	Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is a newly identified K+ channel blocker with hypotensive and antiarrhythmic activities.
S9251	Oxypeucedanin	Oxypeucedanin is a major coumarin aglycone that can be extracted from Ostericum koreanum. It is a kind of open-channel blocker of the hKv1.5 channel.
E0030	NS309	NS309 is a potent and selective activator of human Ca²⁺ -activated K⁺ channels of SK and IK types with an EC50 of 150 nM for hSK3 channel, and displays no activity at BK channels.
S0050	ML277	ML277 (CID-53347902) is a potent activator of KCNQ1 channels with an EC50 of 260 nM and shows >100-fold selectivity over KCNQ2 and KCNQ4.
S0144	ICA 069673	ICA 069673 (compound 51) is an orally active, potent and selective KCNQ2/Q3 potassium channel activator with EC50 of 0.69 μM and 14.3 μM for KCNQ2/Q3 and KCNQ3/Q5, respectively.
S0311	SKA-31	SKA-31(Naphtho[1,2-d]thiazol-2-ylamine) is a potent potassium channel activator with EC50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively.
S0462	NS-1619	NS-1619 is a selective activator of large conductance Ca2+-activated K+-channels.
S0467	Emodepside	Emodepside (QHT06, BAY 44-4400, PF 1022-221), a semisynthetic derivative of PF1022A, is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. Emodepside activates Ca-dependent SLO-1-like K channels.
S1383	Minoxidil	Minoxidil (U-10858) is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth. Minoxidil is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth.	Oncotarget, 2016, 7(43):69703-69717
S1971	Nicorandil	Nicorandil (SG-75) is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).	J Cardiovasc Pharmacol Ther, 2022, 27:10742484221088655 BMC Cardiovasc Disord, 2021, 21(1):302 Sci Rep, 2017, 7(1):3156
S2562	Hydralazine HCl	Hydralazine HCl is a hydrochloride salt of hydralazine, which is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles.	Biogerontology, 2016, 17(5-6):907-920 Xenobiotica, 2014, 44(9):827-41
S4630	Diazoxide	Diazoxide (Sch-6783, SRG-95213, Proglycem) is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.	Br J Pharmacol, 2022, 10.1111/bph.15896 Free Radic Biol Med, 2017, 112:616-630
S4632	Hexachlorophene	Hexachlorophene (Hexachlorofen, Fostril, Nabac, pHisoHex) is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; It can also attenuate Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.	Toxicol Appl Pharmacol, 2022, 441:115988 Cell Chem Biol, 2019, 10.1016/j.chembiol.2019.04.011
S4734	Retigabine 2HCl	Retigabine 2HCl (D-23129) is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels.	Front Physiol, 2021, 12:790580 J Biol Chem, 2021, S0021-9258(21)00985-6 J Neurosci, 2020, 40(34):6522-6535
S6553	ML213	ML213 (CID-3111211) is a selective KCNQ2 (Kv7.2) and KCNQ4 (Kv7.4) potassium channel opener with EC50 of 230 nM and 510 nM, respectively.
S6559	ML-297	ML-297 (VU 0456810, CID 56642816) is a potent and selective activator of Kir3.1/3.2 (G protein-coupled inwardly rectifying potassium, GIRK1/2) channel with EC50 of 0.16 μM and 1.8 μM for GIRK1/2 and GIRK1/4, respectively. ML-297 is potential for the treatment of epilepsy.
S6572	ML335	ML335 is a potent and selective TREK-1/2 activator. ML335 is an agonist for OPRM1-OPRD1 heterdimerization with an EC50 of 403 nM, and selectivities vs. OPRM1, OPRD1, and HTR5A of 37, 2.7, and >99, respectively.
S6978^New	VU0071063	VU0071063 activates heterologously expressed Kir6.2/SUR1 channels with a EC50 of 7 μM, dose dependently and reversibly hyperpolarizes the β-cell membrane potential, which, in turn, inhibits glucose-stimulated Ca²⁺ entry and insulin secretion.
E0378^New	PAP-1	PAP-1 (5-(4-phenoxybutoxy)psoralen), a Kv1.3 antagonist with an EC50 of 2 nM, inhibits the proliferation of human T cells and suppresses delayed type hypersensitivity in rats.
S3151	Gliquidone	Gliquidone (Glurenorm,AR-DF 26) is an ATP-sensitive K⁺ channel antagonist with IC50 of 27.2 nM.	Front Aging Neurosci, 2021, 13:754123 Front Cell Dev Biol, 2020, 8:269 Drug Test Anal, 2018, 10(3):609-617
E0105^New	ICA-27243	ICA-27243, a selective activator of the neuronal M current and KCNQ2/Q3 channels, induces a concentration-dependent increase in a ⁸⁶Rb⁺ efflux from CHO cells expressing KCNQ2/Q3 channels with EC50 of 0.2 μM.
E0034	CyPPA	CyPPA is a subtype-selective positive modulator of SK channels with EC50s of 5.6 μM and 14 μM for hSK3 and hSK2, repectively. CyPPA is inactive on both hSK1 and hIK channels.
S0075	ICA-110381	ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 exhibits KCNQ2/Q3 agonist activity with EC50 of 0.38 μM and KCNQ1 antagonist activity with IC50 of 15 μM, respectively.
S6653	Nigericin (NSC 292567) sodium salt	Nigericin (NSC 292567) sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H⁺, K⁺, and Pb²⁺ ionophore.Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.	J Hazard Mater, 2022, 436:129093 Biomed Pharmacother, 2022, 150:112978 J Virol, 2022, 96(14):e0212721
E0001	DCPIB	DCPIB is a specific and potent inhibitor of volume-regulated anion channels (VRAC). DCPIB potently inhibits several K2P channels with no voltage dependence, including TRESK, TASK1, and TASK3. DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM, demonstrating at least 100-fold higher affinity over TREK1/TRAAK channels. DCPIB is also a novel selective blocker of I(Cl,swell), which blocks native I(Cl,swell) of calf bovine pulmonary artery endothelial (CPAE) cells with an IC(50) of 4.1 μM.
E0012	1-EBIO	1-EBIO (1-Ethylbenzimidazolinone, 1-Ethyl-2-benzimidazolinone）is an activator of Ca2+-sensitive K+ channels with an EC50 of 490 µM in T84 cells.
E0015	Iberiotoxin	Iberiotoxin (IbTX) is a toxin purified from the scorpion Buthus tamulus. Iberiotoxin is a potent blocker of the large conductance Ca(2+)-activated K+ channel with a Kd of ~1 nM.
E0144	Vernakalant (RSD1235) Hydrochloride	Vernakalant (RSD-1235, MK-6621) is a novel, frequency-dependent Na+ channel and early activating K+ channel blocker that selectively prolongs the atrial refractory period.
E0501^New	Senicapoc (ICA-17043)	Senicapoc (ICA-17043) is a Gardos channel(Ca2⁺-activated K⁺ channel; KCa3.1) blocker with an IC50 of 11 nM and produces dose-dependent increases in hemoglobin and decreases in markers of hemolysis. Senicapoc blocks Ca2⁺-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM.
S0087	JNJ 303	JNJ 303 is a potent blocker of the voltage dependent I_Ks-channel encoded by KCNQ1/KCNE1 with IC50 of 64 nM. JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP).
S0090	NS6180	NS-6180 is a highly selective inhibitor of KCa3.1 ion channel with IC50 value of 9 nM, which inhibits T cell activation and inflammation.
S0188	GSK369796 Dihydrochloride	GSK369796 Dihydrochloride (N-tert-butylisoquine) is an inhibitor of hERG potassium ion channel repolarization with IC50 of 7.5 μM. GSK369796 Dihydrochloride is an affordable and effective 4-aminoquinoline antimalarial.
S0398	Astemizole	Astemizole (R 43512) is a histamine H1-receptor antagonist with IC50 of 4.7 nM. Astemizole is also a potent inhibitor of ether à-go-go 1 (Eag1) and Eag-related gene (Erg) potassium channels. Astemizole has antineoplastic and antipruritic effects.
S0476	SCH-23390 hydrochloride	SCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390) is a highly potent and selective dopamine D1-like receptor antagonist with Ki of 0.2 nM and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. SCH-23390 hydrochloride is a potent and high efficacy agonist at h5-HT2C receptors with Ki of 9.3 nM. SCH-23390 hydrochloride directly inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with IC50 of 268 nM.
S0524	A2793	A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is an efficient inhibitor of TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK.
S0741	A2764 dihydrochloride	A2764 dihydrochloride is a selective inhibitor of TRESK (TWIK-related spinal cord K+ channel, K2P18.1) with IC50 of 11.8 μM for the activated mTRESK channel. A2764 dihydrochloride has the potential for probing the role of TRESK channel in migraine and nociception.
S1160	TRAM-34	TRAM-34 (Triarylmethane-34) is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with K_d of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450.	Cell Mol Immunol, 2022, 19(8):925-943 Diabetes Res Clin Pract, 2022, S0168-8227(22)00588-5 Am J Cancer Res, 2020, 10(10):3302-3315
S1344	Glimepiride	Glimepiride(HOE-490) is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus.	Sci Rep, 2017, 7(1):3156
S1426	Repaglinide	Repaglinide (AG-EE 623 ZW) is a potassium channel blocker, which lowers blood glucose by stimulating the release of insulin from the pancreas, used the treatment of type II diabetes.	Drug Metab Dispos, 2019, ;47(3):215-226
S1658	Dofetilide	Dofetilide (UK-68798) is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug.	PLoS Pathog, 2020, 16;16(3):e1008341 Toxicol In Vitro, 2020, 104928 Clin Transl Sci, 2019, 12(6):687-697
S1715	Glipizide	Glipizide (CP-28720,K 4024) is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes.
S1716	Glyburide (Glibenclamide)	Glyburide (Glibenclamide) is a known blocker of vascular ATP-sensitive K+ channels (KATP), used in the treatment of type 2 diabetes.	BMC Vet Res, 2022, 18(1):145 PLoS Negl Trop Dis, 2021, 15(4):e0009304 Front Cell Infect Microbiol, 2021, 11:691445
S1979	Amiodarone (NSC 85442) HCl	Amiodarone (NSC 85442,Amiodar,Amiodarone hydrochloride,Nexterone) HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.	Cell Mol Immunol, 2022, 19(8):925-943 Cell Rep, 2022, 38(10):110468 Front Cell Infect Microbiol, 2021, 11:630812
S2073	Mitiglinide Calcium	Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.
S2114	Dronedarone HCl	Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).	Chem Res Toxicol, 2021, 10.1021/acs.chemrestox.1c00127 Cell Syst, 2019, 8(2):97-108 Nat Commun, 2016, 7:13023
S2405	Sophocarpine	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.	Int J Biol Sci, 2019, 15(11):2497-2508 Front Pharmacol, 2019, 10:1219 J Med Virol, 2019, 91(8):1440-1447
S2443	Tolbutamide (HLS 831)	Tolbutamide (HLS 831) is an inhibitor of potassium channel, used for type II diabetes.	Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918 Hum Cell, 2021, 10.1007/s13577-021-00639-4
S2456	Chlorpromazine HCl	Chlorpromazine HCl (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.	Cell Mol Immunol, 2022, 19(8):925-943 PLoS Pathog, 2022, 18(6):e1010620 Emerg Microbes Infect, 2022, 11(1):1135-1144
S2489	Nateglinide	Nateglinide (Starlix,A-4166,SDZ DJN 608) is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas.	Cell Syst, 2019, 8(2):97-108 Nature, 2018, 560(7718):372-376
S2502	Quinine HCl Dihydrate	Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.	J Pharmacol Toxicol Methods, 2017, 90:39-47
S2601	Gliclazide	Gliclazide(S1702, SE1702) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.	IET Syst Biol, 2021, 10.1049/syb2.12034
S2825	ML133 HCl	ML133 HCl is a selective potassium channel inhibitor for K_ir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on K_ir1.1 and weak activity for K_ir4.1 and K_ir7.1.	Nat Commun, 2022, 13(1):3544 Cell Mol Immunol, 2022, 19(8):925-943 Mol Pain, 2019, 15:1744806919838947
S2967	XE991 dihydrochloride	XE 991 (LS190926) dihydrochloride is a blocker of Kv7 (KCNQ) channels that potently inhibits KCNQ1 (Kv7.1), KCNQ2 (Kv7.2), KCNQ2 + KCNQ3 (Kv7.3) channel, and M-current with IC50 of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively.
S3242	Loureirin B	Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the K_ATP current, influx of Ca²⁺ to the intracellular.
S4037	Doxapram HCl	Doxapram HCl inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.
S4186	Domiphen Bromide	Domiphen bromide (NSC-39415) is a quaternary ammonium antiseptic with actions as a cationic surfactant.
S4353	Terfenadine	Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.
S4439	Almitrine mesylate	Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. Almitrine mesylate inhibits the activity of Ca²⁺-dependent K⁺ channel by decreasing its open probability with IC50 of 0.22 μM.
S4489	Tetraethylammonium chloride	Tetraethylammonium (TEA) chloride is a nonspecific potassium channel blocker with antitumor properties.
S4495	Quinine	Quinine, an alkaloid derived from the bark of the cinchona tree, is an anti-malaria agent and a potassium channel inhibitor that inhibits mSlo3 (KCa 5.1) channel currents evoked by voltage pulses to +100 mV with IC50 of 169 μM.	Cell Mol Immunol, 2022, 19(8):925-943 J Pharmacol Toxicol Methods, 2017, 90:39-47
S4583	Butamben	Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.
S4681	Quinidine hydrochloride monohydrate	Quinidine hydrochloride monohydrate is an anti-arrythmic agent and a potent potassium channel inhibitor with IC50 of 19.9 μM.	J Biomed Res, 2021, 35(5):395-407
S5028	4-Aminopyridine	4-Aminopyridine (4-AP, Fampridine, Dalfampridine) is a potent and non-selective inhibitor of voltage gated potassium channels (Kv) with IC50 values of 170 μM and 230 μM for Kv1.1 and Kv1.2 in CHO cells, respectively.
S5257	Doxapram	Doxapram is a central respiratory stimulant with a brief duration of action. Doxapram is a selective TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel inhibitor with EC50 of 410 nM, 37 μM, 9 μM, respectively.	Biomed Chromatogr, 2018, 32(10)
S5371	Ajmaline	Ajmaline (Cardiorythmine, Tachmalin), found in the root of Rauwolfia serpentina, is a class Ia antiarrhythmic agent.
S5749	Chlorpromazine	Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.	ACS Appl Mater Interfaces, 2022, 14(21):24144-24159 Pharmaceuticals (Basel), 2022, 15(2)241 Bioorg Chem, 2022, 127:106008
S5773	NS1643	NS1643 is one of the small molecule HERG (Kv11.1) channel activators and has also been found to increase erg2 (Kv11.2) currents.
S6174	NS8593 Hydrochloride	NS8593 is a potent negative gating inhibitor of small conductance Ca²⁺ -activated K⁺ channels (SK1-3 or Kca2.1-2.3 channels). NS8593 is also a potent inhibitor of the TRPM7 channel with an IC50 of 1.6 µM.
S6284	Tetraethylammonium bromide	Tetraethylammonium bromide (TEAB, TEA bromide) is used as the source of tetraethylammonium ions in pharmacological and physiological studies, but is also used in organic chemical synthesis. It blocks selective potassium channels.
S6554	ML365	ML365 is a novel selective small molecule inhibitor of the TASK1 or potassium channel, subfamily K, member 9 (KCNK3).
S6627	E-4031 dihydrochloride	E-4031 is an experimental class III antiarrhythmic drug that blocks potassium channels of the hERG-type.
S8016	Vonoprazan Fumarate (TAK-438)	Vonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. Phase 3.
S9223	Talatisamine	Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is a newly identified K+ channel blocker with hypotensive and antiarrhythmic activities.
S9251	Oxypeucedanin	Oxypeucedanin is a major coumarin aglycone that can be extracted from Ostericum koreanum. It is a kind of open-channel blocker of the hKv1.5 channel.
E0030	NS309	NS309 is a potent and selective activator of human Ca²⁺ -activated K⁺ channels of SK and IK types with an EC50 of 150 nM for hSK3 channel, and displays no activity at BK channels.
S0050	ML277	ML277 (CID-53347902) is a potent activator of KCNQ1 channels with an EC50 of 260 nM and shows >100-fold selectivity over KCNQ2 and KCNQ4.
S0144	ICA 069673	ICA 069673 (compound 51) is an orally active, potent and selective KCNQ2/Q3 potassium channel activator with EC50 of 0.69 μM and 14.3 μM for KCNQ2/Q3 and KCNQ3/Q5, respectively.
S0311	SKA-31	SKA-31(Naphtho[1,2-d]thiazol-2-ylamine) is a potent potassium channel activator with EC50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively.
S0462	NS-1619	NS-1619 is a selective activator of large conductance Ca2+-activated K+-channels.
S0467	Emodepside	Emodepside (QHT06, BAY 44-4400, PF 1022-221), a semisynthetic derivative of PF1022A, is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. Emodepside activates Ca-dependent SLO-1-like K channels.
S1383	Minoxidil	Minoxidil (U-10858) is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth. Minoxidil is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth.	Oncotarget, 2016, 7(43):69703-69717
S1971	Nicorandil	Nicorandil (SG-75) is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).	J Cardiovasc Pharmacol Ther, 2022, 27:10742484221088655 BMC Cardiovasc Disord, 2021, 21(1):302 Sci Rep, 2017, 7(1):3156
S2562	Hydralazine HCl	Hydralazine HCl is a hydrochloride salt of hydralazine, which is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles.	Biogerontology, 2016, 17(5-6):907-920 Xenobiotica, 2014, 44(9):827-41
S4630	Diazoxide	Diazoxide (Sch-6783, SRG-95213, Proglycem) is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.	Br J Pharmacol, 2022, 10.1111/bph.15896 Free Radic Biol Med, 2017, 112:616-630
S4632	Hexachlorophene	Hexachlorophene (Hexachlorofen, Fostril, Nabac, pHisoHex) is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; It can also attenuate Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.	Toxicol Appl Pharmacol, 2022, 441:115988 Cell Chem Biol, 2019, 10.1016/j.chembiol.2019.04.011
S4734	Retigabine 2HCl	Retigabine 2HCl (D-23129) is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels.	Front Physiol, 2021, 12:790580 J Biol Chem, 2021, S0021-9258(21)00985-6 J Neurosci, 2020, 40(34):6522-6535
S6553	ML213	ML213 (CID-3111211) is a selective KCNQ2 (Kv7.2) and KCNQ4 (Kv7.4) potassium channel opener with EC50 of 230 nM and 510 nM, respectively.
S6559	ML-297	ML-297 (VU 0456810, CID 56642816) is a potent and selective activator of Kir3.1/3.2 (G protein-coupled inwardly rectifying potassium, GIRK1/2) channel with EC50 of 0.16 μM and 1.8 μM for GIRK1/2 and GIRK1/4, respectively. ML-297 is potential for the treatment of epilepsy.
S6572	ML335	ML335 is a potent and selective TREK-1/2 activator. ML335 is an agonist for OPRM1-OPRD1 heterdimerization with an EC50 of 403 nM, and selectivities vs. OPRM1, OPRD1, and HTR5A of 37, 2.7, and >99, respectively.
S6978^New	VU0071063	VU0071063 activates heterologously expressed Kir6.2/SUR1 channels with a EC50 of 7 μM, dose dependently and reversibly hyperpolarizes the β-cell membrane potential, which, in turn, inhibits glucose-stimulated Ca²⁺ entry and insulin secretion.
E0378^New	PAP-1	PAP-1 (5-(4-phenoxybutoxy)psoralen), a Kv1.3 antagonist with an EC50 of 2 nM, inhibits the proliferation of human T cells and suppresses delayed type hypersensitivity in rats.
S3151	Gliquidone	Gliquidone (Glurenorm,AR-DF 26) is an ATP-sensitive K⁺ channel antagonist with IC50 of 27.2 nM.	Front Aging Neurosci, 2021, 13:754123 Front Cell Dev Biol, 2020, 8:269 Drug Test Anal, 2018, 10(3):609-617
E0105^New	ICA-27243	ICA-27243, a selective activator of the neuronal M current and KCNQ2/Q3 channels, induces a concentration-dependent increase in a ⁸⁶Rb⁺ efflux from CHO cells expressing KCNQ2/Q3 channels with EC50 of 0.2 μM.
E0034	CyPPA	CyPPA is a subtype-selective positive modulator of SK channels with EC50s of 5.6 μM and 14 μM for hSK3 and hSK2, repectively. CyPPA is inactive on both hSK1 and hIK channels.
S0075	ICA-110381	ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 exhibits KCNQ2/Q3 agonist activity with EC50 of 0.38 μM and KCNQ1 antagonist activity with IC50 of 15 μM, respectively.
E0501^New	Senicapoc (ICA-17043)	Senicapoc (ICA-17043) is a Gardos channel(Ca2⁺-activated K⁺ channel; KCa3.1) blocker with an IC50 of 11 nM and produces dose-dependent increases in hemoglobin and decreases in markers of hemolysis. Senicapoc blocks Ca2⁺-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM.
S6978^New	VU0071063	VU0071063 activates heterologously expressed Kir6.2/SUR1 channels with a EC50 of 7 μM, dose dependently and reversibly hyperpolarizes the β-cell membrane potential, which, in turn, inhibits glucose-stimulated Ca²⁺ entry and insulin secretion.
E0378^New	PAP-1	PAP-1 (5-(4-phenoxybutoxy)psoralen), a Kv1.3 antagonist with an EC50 of 2 nM, inhibits the proliferation of human T cells and suppresses delayed type hypersensitivity in rats.
E0105^New	ICA-27243	ICA-27243, a selective activator of the neuronal M current and KCNQ2/Q3 channels, induces a concentration-dependent increase in a ⁸⁶Rb⁺ efflux from CHO cells expressing KCNQ2/Q3 channels with EC50 of 0.2 μM.