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Potassium Channel

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S1979 Amiodarone HCl Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.
Cancer Cell, 2025, 43(4):776-796.e14
J Immunother Cancer, 2024, 12(11)e009805
Cell Rep Methods, 2023, 3(4):100440
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S2443 Tolbutamide (HLS 831) Tolbutamide (HLS 831) is an inhibitor of potassium channel, used for type II diabetes.
Adv Healthc Mater, 2024, e2303785.
iScience, 2024, 27(10):110862
UNIVERSITY OF PÉCS, 2023,
S1716 Glyburide (Glibenclamide) Glyburide (Glibenclamide), a known blocker of vascular ATP-sensitive K+ channels (KATP), is used in the treatment of type 2 diabetes.
Cell Chem Biol, 2023, S2451-9456(23)00335-5
BMC Vet Res, 2022, 18(1):145
Front Cell Infect Microbiol, 2021, 11:691445
S1658 Dofetilide Dofetilide (UK-68798) is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug.
Autophagy, 2025, 1-17.
PLoS Pathog, 2020, 16;16(3):e1008341
Toxicol In Vitro, 2020, 104928
S2825 ML133 HCl ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.
Cell Mol Immunol, 2022, 19(8):925-943
Cellular & Molecular Immunology, 2022, 925–943
Nat Commun, 2022, 13(1):3544
E4788 Nigericin Nigericin is an antibiotic derived from Streptomyces hygroscopicus that acts as a K+/H+ ionophore, which causes the efflux of potassium from the cell and, thus, influences the mitochondria membrane potential. It also induces pyroptosis in macrophages by activating NLRP3 inflammasome.
Frontiers in Immunology, 2026, 1534567
Cell Mol Immunol, 2025, 22(11):1478-1490
Cell Death Dis, 2025, 16(1):465
S1160 TRAM-34 TRAM-34 (Triarylmethane-34) is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450.
Nat Commun, 2024, 15(1):7566
Pflugers Arch, 2023, 475(3):405-416
Cell Mol Immunol, 2022, 19(8):925-943
S1971 Nicorandil Nicorandil (SG-75) is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).
J Immunother Cancer, 2024, 12(11)e009805
J Cardiovasc Pharmacol Ther, 2022, 27:10742484221088655
BMC Cardiovasc Disord, 2021, 21(1):302
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S1715 Glipizide Glipizide (CP-28720,K 4024) is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes.
Journal of Experimental & Clinical Cancer Research, 2025, 294
J Exp Clin Cancer Res, 2025, 44(1):294
Communications Medicine, 2025, 420
S4734 Retigabine 2HCl Retigabine 2HCl (D-23129) is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels.
J Biol Chem, 2021, S0021-9258(21)00985-6
Front Physiol, 2021, 12:790580
SSRN, 2021, 25 Pages

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