Home Immunology & Inflammation Parasite inhibitor - Potassium Channel activator Emodepside For research use only.

Emodepside

Synonyms: QHT06, BAY 44-4400, PF 1022-221

Emodepside (QHT06, BAY 44-4400, PF 1022-221), a semisynthetic derivative of PF1022A, is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. Emodepside activates Ca-dependent SLO-1-like K channels.

Emodepside Chemical Structure

Emodepside Chemical Structure

CAS: 155030-63-0

Purity & Quality Control

Batch: S046701 DMSO] 100 mg/mL] false] Ethanol] 20 mg/mL] false] Water] Insoluble] false Purity: 99.67%
99.67

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Biological Activity

Description Emodepside (QHT06, BAY 44-4400, PF 1022-221), a semisynthetic derivative of PF1022A, is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. Emodepside activates Ca-dependent SLO-1-like K channels.
Targets
Ca-dependent SLO-1-like K channels [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05538767 Completed
Hookworm Infections
Jennifer Keiser|Public Health Laboratory Ivo de Carneri|Swiss Tropical & Public Health Institute
 September 16 2022 Phase 2
NCT05017194 Completed
Trichuris Trichiura; Infection|Hookworm Infections
Jennifer Keiser|Public Health Laboratory Ivo de Carneri|Swiss Tropical & Public Health Institute
 August 2 2021 Phase 2
NCT03383614 Completed
Filariasis
Drugs for Neglected Diseases|Bayer|Bill and Melinda Gates Foundation
 November 14 2017 Phase 1
NCT03383523 Completed
Filariasis
Drugs for Neglected Diseases|Bayer|Bill and Melinda Gates Foundation
 October 26 2017 Phase 1
NCT02661178 Completed
Healthy Volunteers
Drugs for Neglected Diseases|Bayer|Bill and Melinda Gates Foundation
 December 2015 Phase 1

Chemical Information & Solubility

Molecular Weight 1119.39 Formula

C60H90N6O14
CAS No. 155030-63-0 SDF --
Smiles CC1C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)O1)CC(C)C)C)CC2=CC=C(C=C2)N3CCOCC3)CC(C)C)C)C)CC(C)C)C)CC4=CC=C(C=C4)N5CCOCC5)CC(C)C)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (89.33 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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