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Emodepside Parasite inhibitor

Name: Emodepside
Brand: Selleck Chemicals
SKU: S0467
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S0467

Emodepside (QHT06, BAY 44-4400, PF 1022-221), a semisynthetic derivative of PF1022A, is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. This compound activates Ca-dependent SLO-1-like K channels.

Chemical Structure

Molecular Weight: 1119.39

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Quality Control

Batch: S046701 DMSO]100 mg/mL]false]Ethanol]20 mg/mL]false]Water]Insoluble]false Purity: 99.67%

Cited in Nature Medicine for its top-tier quality
COA
HPLC
SDS
Datasheet

99.67

Related Targets	PD-1/PD-L1 CXCR STING AhR Immunology & Inflammation related CD markers Interleukins Anti-infection Antioxidant COX
Other Parasite Inhibitors	Diminazene Aceturate Oxibendazole Avermectin B1 (+/-)-nerolidol Milbemycin Oxime Arteether Eprinomectin Diclazuril Selamectin Oxfendazole

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (89.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	1119.39	Formula	C₆₀H₉₀N₆O₁₄	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	155030-63-0	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	QHT06, BAY 44-4400, PF 1022-221			Smiles	CC1C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)O1)CC(C)C)C)CC2=CC=C(C=C2)N3CCOCC3)CC(C)C)C)C)CC(C)C)C)CC4=CC=C(C=C4)N5CCOCC5)CC(C)C)C

Mechanism of Action

Targets/IC₅₀/Ki	Ca-dependent SLO-1-like K channels
References	[1] https://pubmed.ncbi.nlm.nih.gov/16228263/ [2] https://pubmed.ncbi.nlm.nih.gov/21486286/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06373835	Not yet recruiting	Strongyloides Stercoralis Infection\|Strongyloidiasis	Swiss Tropical & Public Health Institute\|National Institute of Public Health Vientiane Laos	May 1 2024	Phase 2
NCT05538767	Completed	Hookworm Infections	Jennifer Keiser\|Public Health Laboratory Ivo de Carneri\|Swiss Tropical & Public Health Institute	September 16 2022	Phase 2
NCT05017194	Completed	Trichuris Trichiura; Infection\|Hookworm Infections	Jennifer Keiser\|Public Health Laboratory Ivo de Carneri\|Swiss Tropical & Public Health Institute	August 2 2021	Phase 2
NCT03383614	Completed	Filariasis	Drugs for Neglected Diseases\|Bayer\|Bill and Melinda Gates Foundation	November 14 2017	Phase 1
NCT03383523	Completed	Filariasis	Drugs for Neglected Diseases\|Bayer\|Bill and Melinda Gates Foundation	October 26 2017	Phase 1
NCT02661178	Completed	Healthy Volunteers	Drugs for Neglected Diseases\|Bayer\|Bill and Melinda Gates Foundation	December 2015	Phase 1

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