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Emodepside Parasite inhibitor

Name: Emodepside
Brand: Selleck Chemicals
SKU: S0467
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.S0467

Emodepside (QHT06, BAY 44-4400, PF 1022-221), a semisynthetic derivative of PF1022A, is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. This compound activates Ca-dependent SLO-1-like K channels.

Chemical Structure

Molecular Weight: 1119.39

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Quality Control

Batch: S046701 DMSO]100 mg/mL]false]Ethanol]20 mg/mL]false]Water]Insoluble]false Purity: 99.67%

Cited in Nature Medicine for its top-tier quality
COA
HPLC
SDS/MSDS
Datasheet

99.67

Related Targets	PD-1/PD-L1 CXCR STING AhR Immunology & Inflammation related CD markers Interleukins Anti-infection Antioxidant COX
Other Parasite Inhibitors	Diminazene Aceturate Oxfendazole Oxibendazole (+/-)-nerolidol Avermectin B1 Milbemycin Oxime Arteether Eprinomectin Diclazuril Selamectin

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (89.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5mg/ml (4.47mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.71mg/ml (0.63mM)	Taking the 1 mL working solution as an example, add 50 μL of 14.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	1119.39	Formula	C₆₀H₉₀N₆O₁₄	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	155030-63-0	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	QHT06, BAY 44-4400, PF 1022-221			SMILES	CC1C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)O1)CC(C)C)C)CC2=CC=C(C=C2)N3CCOCC3)CC(C)C)C)C)CC(C)C)C)CC4=CC=C(C=C4)N5CCOCC5)CC(C)C)C

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	Ca-dependent SLO-1-like K channels
References	[1] https://pubmed.ncbi.nlm.nih.gov/16228263/ [2] https://pubmed.ncbi.nlm.nih.gov/21486286/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-14)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06800248	NOT_YET_RECRUITING	Trichuris Trichiura; Infection; Hookworm Infection; Ascaris Lumbricoides Infection	Swiss Tropical & Public Health Institute	2026-11-06	PHASE3
NCT07258173	NOT_YET_RECRUITING	Trichuris Infection	Jennifer Keiser	2026-11-15	PHASE2
NCT05180461	ACTIVE_NOT_RECRUITING	Onchocerciasis	Drugs for Neglected Diseases	2021-08-30	PHASE2
NCT06736691	ACTIVE_NOT_RECRUITING	Trichuris Trichiura; Infection; Hookworm Infection; Ascaris Lumbricoides Infection	Swiss Tropical & Public Health Institute	2025-11-25	PHASE3
NCT06373835	COMPLETED	Strongyloides Stercoralis Infection; Strongyloidiasis	Swiss Tropical & Public Health Institute	2024-05-20	PHASE2
NCT06412926	COMPLETED	Soil-transmitted Helminth Infection; Onchocerciasis (River Blindness)	Bayer	2024-05-07	PHASE1

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