Home Transmembrane Transporters Potassium Channel antagonist Gliquidone

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Gliquidone Potassium Channel antagonist

Cat.No.S3151

Gliquidone (Glurenorm,AR-DF 26) is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.
Gliquidone Potassium Channel antagonist Chemical Structure

Chemical Structure

Molecular Weight: 527.63

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Chemical Information, Storage & Stability

Molecular Weight 527.63 Formula

C27H33N3O6S

 Storage (From the date of receipt)
CAS No. 33342-05-1 -- Storage of Stock Solutions

Synonyms Glurenorm,AR-DF 26 Smiles CC1(C2=C(C=C(C=C2)OC)C(=O)N(C1=O)CCC3=CC=C(C=C3)S(=O)(=O)NC(=O)NC4CCCCC4)C

Solubility

In vitro
Batch:

DMSO : 105 mg/mL (199.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 6 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

Targets/IC50/Ki
Potassium channel [1]
27.2 nM
In vivo

Gliquidone (0.1–1.0 μg per mouse i.c.v.) prevents antinociception produced by amitriptyline and clomipramine in a dose-dependent manner in male swiss albino mice. [2] This compound (0.06–16 μg per mouse, i.c.v.) antagonizes the antinociception induced by buprenorphine, morphine and methadone. [3] This chemical (6 μg per mouse, i.c.v.) prevents the antinociception induced by clonidine (0.125 mg/kg, s.c.) and guanabenz (0.30 mg/kg, s.c.), while a lower dose of this compound (3 μg per mouse, i.c.v.) is ineffective. [4] Glurenorm (10 mg/kg) given to the diabetic rats produces significant reductions in blood glucose, nonenzymatic glycosylation, and total protein in the lenses, and significantly increases in glutathione levels in the lenses. [5]
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/10205011/
  • [5] https://pubmed.ncbi.nlm.nih.gov/11677036/

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