Gliquidone

Catalog No.S3151 Synonyms: Glurenorm

Gliquidone Chemical Structure

Molecular Weight(MW): 527.63

Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 97 In stock
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Biological Activity

Description Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.
Targets
Potassium channel [1]
27.2 nM
In vivo Gliquidone (0.1–1.0 μg per mouse i.c.v.) prevents antinociception produced by amitriptyline and clomipramine in a dose-dependent manner in male swiss albino mice. [2] Gliquidone (0.06–16 μg per mouse, i.c.v.) antagonizes the antinociception induced by buprenorphine, morphine and methadone. [3] Gliquidone (6 μg per mouse, i.c.v.) prevents the antinociception induced by clonidine (0.125 mg/kg, s.c.) and guanabenz (0.30 mg/kg, s.c.), while a lower dose of gliquidone (3 μg per mouse, i.c.v.) is ineffective. [4] Glurenorm (10 mg/kg) given to the diabetic rats produces significant reductions in blood glucose, nonenzymatic glycosylation, and total protein in the lenses, and significantly increases in glutathione levels in the lenses. [5]

Protocol

Solubility (25°C)

In vitro DMSO 105 mg/mL (199.0 mM)
Ethanol 6 mg/mL (11.37 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+corn oil
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 527.63
Formula

C27H33N3O6S

CAS No. 33342-05-1
Storage powder
in solvent
Synonyms Glurenorm

Bio Calculators

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Potassium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID