Catalog No.S3151 Synonyms: Glurenorm
Molecular Weight(MW): 527.63
Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.
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|Description||Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.|
|In vivo||Gliquidone (0.1–1.0 μg per mouse i.c.v.) prevents antinociception produced by amitriptyline and clomipramine in a dose-dependent manner in male swiss albino mice.  Gliquidone (0.06–16 μg per mouse, i.c.v.) antagonizes the antinociception induced by buprenorphine, morphine and methadone.  Gliquidone (6 μg per mouse, i.c.v.) prevents the antinociception induced by clonidine (0.125 mg/kg, s.c.) and guanabenz (0.30 mg/kg, s.c.), while a lower dose of gliquidone (3 μg per mouse, i.c.v.) is ineffective.  Glurenorm (10 mg/kg) given to the diabetic rats produces significant reductions in blood glucose, nonenzymatic glycosylation, and total protein in the lenses, and significantly increases in glutathione levels in the lenses. |
-  Angel I, et al. Fundam Clin Pharmacol, 1991, 5(2), 107-115.
-  Galeotti N, et al. Neuropharmacology, 2001, 40(1), 75-84.
-  Ocana M, et al. Br J Pharmacol, 1995, 114(6), 1296-1302.
|In vitro||DMSO||105 mg/mL (199.0 mM)|
|Ethanol||6 mg/mL (11.37 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+corn oil
For best results, use promptly after mixing.
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