Catalog No.S2601

For research use only.

Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.

Gliclazide  Chemical Structure

CAS No. 21187-98-4

Selleck's Gliclazide has been cited by 1 Publication

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Biological Activity

Description Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.
Potassium channel [1]
184 nM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 65 mg/mL
(200.98 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 323.41


CAS No. 21187-98-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04198948 Completed Drug: Omeprazole|Drug: Placebo oral tablet|Drug: Gliclazide Diabetes Mellitus Type 2 University of Sarajevo|General Hospital Prim. Dr. Abdulah Nakas|University of Dundee|Wellcome Trust March 4 2019 Phase 1
NCT03705195 Completed Drug: Gliclazide Type 2 Diabetes Mellitus University of Dundee|NHS Tayside August 3 2018 Not Applicable
NCT03467971 Completed Drug: Metformin/Gliclazide Fixed Combination Healthy Merck KGaA Darmstadt Germany March 6 2018 Phase 1
NCT02643329 Completed Drug: BF-Gliclazide Tablet 80mg|Drug: Diamicron 80mg Tablet Healthy Bright Future Pharmaceuticals Factory O/B Bright Future Pharmaceutical Laboratories Limited|Chinese University of Hong Kong January 2016 Phase 1

(data from, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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