Home Transmembrane Transporters Potassium Channel antagonist VU0463271 For research use only.

VU0463271

VU0463271 is a selective and potent antagonist of neuronal-specific potassium-chloride cotransporter 2 KCC2, with an IC50 of 61 nM. VU0463271 demonstrates over 100-fold selectivity compared to the closely related Na-K-2Cl cotransporter 1 (NKCC1).

VU0463271 Chemical Structure

VU0463271 Chemical Structure

CAS: 1391737-01-1

Purity & Quality Control

Batch: E163201 DMSO] 26 mg/mL] false] Ethanol] 2 mg/mL] false] Water] Insoluble] false Purity: 99.82%
99.82

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Biological Activity

Description VU0463271 is a selective and potent antagonist of neuronal-specific potassium-chloride cotransporter 2 KCC2, with an IC50 of 61 nM. VU0463271 demonstrates over 100-fold selectivity compared to the closely related Na-K-2Cl cotransporter 1 (NKCC1).

Chemical Information & Solubility

Molecular Weight 382.51 Formula

C19H18N4OS2
CAS No. 1391737-01-1 SDF Download VU0463271 SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 26 mg/mL ( (67.97 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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