Quinine HCl Dihydrate
For research use only.
CAS No. 6119-47-7
Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.
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|Description||Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.|
Quinine blocks Cx36 and Cx50 junctional currents in a reversible and concentration-dependent manner with half maximal blocking concentrations of 32 mM and 73 mM, respectively. Quinine induces slow transitions between open and fully closed states that decreased open probability of the channel. Quinine thus offers a potentially useful method to block certain types of gap junction channels, including those between neurons that are formed by Cx36.  Quinine, a K+ channel blocker, prevents formation of tumor necrosis factor (TNF) as well as the subsequent hepatic DNA fragmentation and liver enzyme leakage.  Quinine elicits Fos-like immunoreactivity (FLI) concentrated in the medial third of the nucleus; acid elicited more broadly distributed FLI concentrated farther laterally.  Quinine has a relatively weak effect on doxorubicin accumulation but was able to completely restore doxorubicin sensitivity in the resistant cells. Quinine also modifies the intracellular tolerance to doxorubicin, which suggests that it is able to modify drug distribution within the cells.  Quinine primarily blocks the whole cell potassium currents (IK) in a voltage-dependent manner. Quinine also reduces the size of sodium currents (INa) in a use-dependent manner, while leaving calcium currents (ICa) relatively unaffected. 
-  Srinivas M, et al. Proc Natl Acad Sci U S A,?001, 98(19), 10942-10947.
-  Gantner F, et al. Eur J Pharmacol,?995, 294(1), 353-355.
-  Travers SP, et al. Am J Physiol Regul Integr Comp Physiol,?002, 282(6), R1798-1810.
|In vitro||DMSO||79 mg/mL (199.03 mM)|
|Ethanol||79 mg/mL (199.03 mM)|
|Water||43 mg/mL (108.33 mM)|
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Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02817919||Completed||--||Malaria||African Collaborating Centre for Pharmacovigilance|Kintampo Health Research Centre Ghana|University of Health and Allied Sciences||May 2016||--|
|NCT02598713||Recruiting||Drug: Aspiration Marker||Pneumonia|Aspiration||Massachusetts General Hospital||December 2015||Phase 1|
|NCT01851473||Completed||Drug: cocaine|Drug: quinine|Drug: acetazolamide||Cocaine Use|Pharmacokinetics||National Institute on Drug Abuse (NIDA)|National Institutes of Health Clinical Center (CC)||October 24 2012||Phase 1|
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