Quinine HCl Dihydrate
Molecular Weight(MW): 396.91
Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.
Purity & Quality Control
Choose Selective Potassium Channel Inhibitors
|Description||Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.|
Quinine blocks Cx36 and Cx50 junctional currents in a reversible and concentration-dependent manner with half maximal blocking concentrations of 32 mM and 73 mM, respectively. Quinine induces slow transitions between open and fully closed states that decreased open probability of the channel. Quinine thus offers a potentially useful method to block certain types of gap junction channels, including those between neurons that are formed by Cx36.  Quinine, a K+ channel blocker, prevents formation of tumor necrosis factor (TNF) as well as the subsequent hepatic DNA fragmentation and liver enzyme leakage.  Quinine elicits Fos-like immunoreactivity (FLI) concentrated in the medial third of the nucleus; acid elicited more broadly distributed FLI concentrated farther laterally.  Quinine has a relatively weak effect on doxorubicin accumulation but was able to completely restore doxorubicin sensitivity in the resistant cells. Quinine also modifies the intracellular tolerance to doxorubicin, which suggests that it is able to modify drug distribution within the cells.  Quinine primarily blocks the whole cell potassium currents (IK) in a voltage-dependent manner. Quinine also reduces the size of sodium currents (INa) in a use-dependent manner, while leaving calcium currents (ICa) relatively unaffected. 
-  Srinivas M, et al. Proc Natl Acad Sci U S A,?001, 98(19), 10942-10947.
-  Gantner F, et al. Eur J Pharmacol,?995, 294(1), 353-355.
-  Travers SP, et al. Am J Physiol Regul Integr Comp Physiol,?002, 282(6), R1798-1810.
|In vitro||DMSO||79 mg/mL (199.03 mM)|
|Ethanol||79 mg/mL (199.03 mM)|
|Water||43 mg/mL (108.33 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02817919||Completed||--||Malaria||African Collaborating Centre for Pharmacovigilance|Kintampo Health Research Centre Ghana|University of Health and Allied Sciences||May 2016||--|
|NCT02598713||Recruiting||Drug: Aspiration Marker||Pneumonia|Aspiration||Massachusetts General Hospital||December 2015||Phase 1|
|NCT01851473||Completed||Drug: cocaine|Drug: quinine|Drug: acetazolamide||Cocaine Use|Pharmacokinetics||National Institute on Drug Abuse (NIDA)|National Institutes of Health Clinical Center (CC)||October 24 2012||Phase 1|
|NCT00785551||Terminated||Drug: quinine sulfate||Healthy|Renal Impairment||Mutual Pharmaceutical Company Inc.||November 2007||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.