Quinine HCl Dihydrate

Catalog No.S2502

Quinine HCl Dihydrate Chemical Structure

Molecular Weight(MW): 396.91

Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 270 In stock
USD 570 In stock
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Biological Activity

Description Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.
Targets
Potassium channel [1]
In vitro

Quinine blocks Cx36 and Cx50 junctional currents in a reversible and concentration-dependent manner with half maximal blocking concentrations of 32 mM and 73 mM, respectively. Quinine induces slow transitions between open and fully closed states that decreased open probability of the channel. Quinine thus offers a potentially useful method to block certain types of gap junction channels, including those between neurons that are formed by Cx36. [1] Quinine, a K+ channel blocker, prevents formation of tumor necrosis factor (TNF) as well as the subsequent hepatic DNA fragmentation and liver enzyme leakage. [2] Quinine elicits Fos-like immunoreactivity (FLI) concentrated in the medial third of the nucleus; acid elicited more broadly distributed FLI concentrated farther laterally. [3] Quinine has a relatively weak effect on doxorubicin accumulation but was able to completely restore doxorubicin sensitivity in the resistant cells. Quinine also modifies the intracellular tolerance to doxorubicin, which suggests that it is able to modify drug distribution within the cells. [4] Quinine primarily blocks the whole cell potassium currents (IK) in a voltage-dependent manner. Quinine also reduces the size of sodium currents (INa) in a use-dependent manner, while leaving calcium currents (ICa) relatively unaffected. [5]

Protocol

Solubility (25°C)

In vitro DMSO 79 mg/mL (199.03 mM)
Ethanol 79 mg/mL (199.03 mM)
Water 43 mg/mL (108.33 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 396.91
Formula

C20H24N2O2.HCl.2H2O

CAS No. 6119-47-7
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02817919 Completed -- Malaria African Collaborating Centre for Pharmacovigilance|Kintampo Health Research Centre Ghana|University of Health and Allied Sciences May 2016 --
NCT02598713 Recruiting Drug: Aspiration Marker Pneumonia|Aspiration Massachusetts General Hospital December 2015 Phase 1
NCT01851473 Completed Drug: cocaine|Drug: quinine|Drug: acetazolamide Cocaine Use|Pharmacokinetics National Institute on Drug Abuse (NIDA)|National Institutes of Health Clinical Center (CC) October 24 2012 Phase 1
NCT00785551 Terminated Drug: quinine sulfate Healthy|Renal Impairment Mutual Pharmaceutical Company Inc. November 2007 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID