Quinine HCl Dihydrate

Catalog No.S2502

For research use only.

Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.

Quinine HCl Dihydrate Chemical Structure

CAS No. 6119-47-7

Selleck's Quinine HCl Dihydrate has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.
Targets
Potassium channel [1]
In vitro

Quinine blocks Cx36 and Cx50 junctional currents in a reversible and concentration-dependent manner with half maximal blocking concentrations of 32 mM and 73 mM, respectively. Quinine induces slow transitions between open and fully closed states that decreased open probability of the channel. Quinine thus offers a potentially useful method to block certain types of gap junction channels, including those between neurons that are formed by Cx36. [1] Quinine, a K+ channel blocker, prevents formation of tumor necrosis factor (TNF) as well as the subsequent hepatic DNA fragmentation and liver enzyme leakage. [2] Quinine elicits Fos-like immunoreactivity (FLI) concentrated in the medial third of the nucleus; acid elicited more broadly distributed FLI concentrated farther laterally. [3] Quinine has a relatively weak effect on doxorubicin accumulation but was able to completely restore doxorubicin sensitivity in the resistant cells. Quinine also modifies the intracellular tolerance to doxorubicin, which suggests that it is able to modify drug distribution within the cells. [4] Quinine primarily blocks the whole cell potassium currents (IK) in a voltage-dependent manner. Quinine also reduces the size of sodium currents (INa) in a use-dependent manner, while leaving calcium currents (ICa) relatively unaffected. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 79 mg/mL
(199.03 mM)
Ethanol 79 mg/mL
(199.03 mM)
Water 43 mg/mL
(108.33 mM)

Chemical Information

Molecular Weight 396.91
Formula

C20H24N2O2.HCl.2H2O

CAS No. 6119-47-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.O.O.Cl

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04873011 Recruiting Drug: Quinine Hydrochloride|Drug: Placebo Obesity Universitaire Ziekenhuizen Leuven October 29 2020 Phase 1
NCT02817919 Completed -- Malaria African Collaborating Centre for Pharmacovigilance|Kintampo Health Research Centre Ghana|University of Health and Allied Sciences May 2016 --
NCT02598713 Recruiting Drug: Aspiration Marker Pneumonia|Aspiration Massachusetts General Hospital December 2015 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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