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DCPIB Potassium Channel inhibitor

Cat.No.E0001

DCPIB is a specific and potent inhibitor of volume-regulated anion channels (VRAC). This compound potently inhibits several K2P channels with no voltage dependence, including TRESK, TASK1, and TASK3. It displayed superior selectivity toward TRESK with an IC50 of 0.14 μM, demonstrating at least 100-fold higher affinity over TREK1/TRAAK channels. This chemical is also a novel selective blocker of I(Cl,swell), which blocks native I(Cl,swell) of calf bovine pulmonary artery endothelial (CPAE) cells with an IC(50) of 4.1 μM.
DCPIB Potassium Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 427.36

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Quality Control

Batch: E000101 DMSO]85 mg/mL]false]Ethanol]85 mg/mL]false]Water]Insoluble]false Purity: 99.99%
99.99

Chemical Information, Storage & Stability

Molecular Weight 427.36 Formula

C22H28Cl2O4

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 82749-70-0 -- Storage of Stock Solutions

Synonyms N/A Smiles CCCCC1(CC2=CC(=C(Cl)C(=C2C1=O)Cl)OCCCC(O)=O)C3CCCC3

Solubility

In vitro
Batch:

DMSO : 85 mg/mL (198.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 85 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
VRAC [1]
TRESK [1]
0.14 μM
I(Cl,swell) [2]
(in CPAE Cells)
4.1 μM
References

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