WH-4-023

For research use only.

Catalog No.S7565 Synonyms: KIN001-112, KIN112

7 publications

WH-4-023 Chemical Structure

CAS No. 837422-57-8

WH-4-023 (KIN001-112, KIN112) is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.

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Selleck's WH-4-023 has been cited by 7 publications

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  • (G-I) WB analysis of total LCK, LCK Y505, and Src Y416 expression in ALL-SIL, CCRF-CEM, and TALL-1. Cells were treated with DMSO only (Ctrl), dasatinib, bosutinib, nintedanib, or WH-4-023 overnight at the compound concentrations corresponding to the GI50 at 48 hr. Bos, bosutinib; Das, dasatinib; Nint, nintedanib; WH, WH-4-023.

    Blood, 2017, 130(25):2750-2761. WH-4-023 purchased from Selleck.

Purity & Quality Control

Choose Selective Src Inhibitors

Biological Activity

Description WH-4-023 (KIN001-112, KIN112) is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.
Targets
Lck [1]
(Cell-free assay)
Src [1]
(Cell-free assay)
2 nM 6 nM
In vitro

WH-4-023 shows little activity on p38 and KDR. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human EM-2 cell NWHQfY1lT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFvyS5dKdmirYnn0bY9vKG:oIHj1cYFvKEWPLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlky\S1yODFOwG0> MV;TRW5ITVJ?
human LAMA-84 cell NWHQW2UxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXv1Oop3UW6qaXLpeIlwdiCxZjDoeY1idiCOQV3BMVg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oy55OHWtNFYh|ryP NYHhVWVDW0GQR1XS
human EoL-1-cell cell NE\R[2RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGPhTHdKdmirYnn0bY9vKG:oIHj1cYFvKEWxTD2xMYNmdGxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD17LkWx[U0xPiEQvF2= MlvHV2FPT0WU
human MEG-01 cell NXGxS2FsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NInnc41KdmirYnn0bY9vKG:oIHj1cYFvKE2HRz2wNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjOnLUC1JO69VQ>? MUHTRW5ITVJ?
human CTV-1 cell NXvwR5lxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MljHTY5pcWKrdHnvckBw\iCqdX3hckBEXFZvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNVhmNTB3IN88US=> NGO5b41USU6JRWK=
human BL-70 cell MoLXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{focWlvcGmkaYTpc44hd2ZiaIXtZY4hSkxvN{CgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20Mlcz\S1yNTFOwG0> MkD5V2FPT0WU
human K-562 cell Mn[xS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWXybGxKUW6qaXLpeIlwdiCxZjDoeY1idiCNLUW2NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODByMU[yJO69VQ>? MY\TRW5ITVJ?
human BV-173 cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NU\0e3hrUW6qaXLpeIlwdiCxZjDoeY1idiCEVj2xO|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjByMEWxOEDPxE1? MkHMV2FPT0WU
human DOHH-2 cell MoLoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXXzfmhxUW6qaXLpeIlwdiCxZjDoeY1idiCGT1jIMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjByMEW5O{DPxE1? NFHDZ2ZUSU6JRWK=
human A704 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmnCTY5pcWKrdHnvckBw\iCqdX3hckBCPzB2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wNFEzPyEQvF2= M3nXTHNCVkeHUh?=
human NCI-SNU-16 cell NUXyWVF6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHXjR3BKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3TUnUuOTZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkCxOVczKM7:TR?= NWfHV5B3W0GQR1XS
human LC-2-ad cell NH\WWmpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1XOU2lvcGmkaYTpc44hd2ZiaIXtZY4hVENvMj3h[EBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODJyM{Og{txO Mn[4V2FPT0WU
human LB2518-MEL cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWrJcohq[mm2aX;uJI9nKGi3bXHuJGxDOjVzOD3NSWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB2Nk[3JO69VQ>? NVyzO5NmW0GQR1XS
human D-336MG cell NX7WVWNZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Moq1TY5pcWKrdHnvckBw\iCqdX3hckBFNTN|Nl3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xPDZ6MTFOwG0> MoXaV2FPT0WU
human LB996-RCC cell M2TER2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2iyXGlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ7OU[tVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yNU[2PEDPxE1? NHPM[pVUSU6JRWK=
human Becker cell NILXPHdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3rsVWlvcGmkaYTpc44hd2ZiaIXtZY4hSmWla3XyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xPjN6MTFOwG0> MVHTRW5ITVJ?
human LB1047-RCC cell M1TYSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{LqOmlvcGmkaYTpc44hd2ZiaIXtZY4hVEJzMES3MXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMEe1PVIh|ryP MoLoV2FPT0WU
human KS-1 cell M3vMOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXXJcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkC3O|U5KM7:TR?= MkXtV2FPT0WU
human MPP-89 cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV;Jcohq[mm2aX;uJI9nKGi3bXHuJG1RWC16OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNFgzOjlizszN NXnrVVB4W0GQR1XS
human RXF393 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{nqVmlvcGmkaYTpc44hd2ZiaIXtZY4hWliIM{mzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yODZ|MzFOwG0> M3;adnNCVkeHUh?=
LB831-BLC cell MoDnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mmi0TY5pcWKrdHnvckBw\iCqdX3hckBNSjh|MT3CUGMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjF{N{G1JO69VQ>? NFH4W2tUSU6JRWK=
HUTU-80 cell Ml\LS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV\Jcohq[mm2aX;uJI9nKGi3bXHuJGhWXFVvOECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlE4PTJ7IN88US=> NX;IRW1IW0GQR1XS
A498 cell M2nQ[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MonkTY5pcWKrdHnvckBw\iCqdX3hckBCPDl6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6xPFk1PSEQvF2= MWTTRW5ITVJ?
MZ1-PC cell NF;sTVlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NE\nNodKdmirYnn0bY9vKG:oIHj1cYFvKE2cMT3QR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOjJ5MU[g{txO NXTyUWRlW0GQR1XS
TE-8 cell NITaVlNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUnJcohq[mm2aX;uJI9nKGi3bXHuJHRGNThiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkKzPVI1KM7:TR?= MWXTRW5ITVJ?
MFH-ino cell  MkC1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3;UXWlvcGmkaYTpc44hd2ZiaIXtZY4hVU[KLXnuc{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOjN7MkWg{txO MWDTRW5ITVJ?
TE-15 cell MnLqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2PDWWlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlI1Ojd4IN88US=> MXXTRW5ITVJ?
NTERA-S-cl-D1 cell M3TCR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmfhTY5pcWKrdHnvckBw\iCqdX3hckBPXEWUQT3TMYNtNURzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yPFg2PSEQvF2= NIX6eHFUSU6JRWK=
COLO-829 cell MliwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFHYZ3BKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:tPFI6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5|MUKxNkDPxE1? NWjRRpVmW0GQR1XS
SW684 cell NH3K[mVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHzwVlhKdmirYnn0bY9vKG:oIHj1cYFvKFOZNki0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{OjV6ODFOwG0> NHO1cmdUSU6JRWK=
OS-RC-2 cell MoKzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3jwZ2lvcGmkaYTpc44hd2ZiaIXtZY4hV1NvUlOtNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOzVyMUGg{txO MlHFV2FPT0WU
IST-MES1 cell M3HPfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXPJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2PRWOxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{PTd{MzFOwG0> MmHsV2FPT0WU
SNB75 cell NFfMPHFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIPHT5FKdmirYnn0bY9vKG:oIHj1cYFvKFOQQke1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{PTd5NDFOwG0> M3WxUnNCVkeHUh?=
SW954 cell M4PmcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mny1TY5pcWKrdHnvckBw\iCqdX3hckBUXzl3NDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuN|cyPjNizszN NUfDOXdsW0GQR1XS
RCC10RGB cell NIfBVXdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGPub4RKdmirYnn0bY9vKG:oIHj1cYFvKFKFQ{GwVmdDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC52Mk[zNUDPxE1? MXfTRW5ITVJ?
VA-ES-BJ cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlPRTY5pcWKrdHnvckBw\iCqdX3hckBXSS2HUz3CTkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPDZ{NjFOwG0> NGDBW4hUSU6JRWK=
NCI-H1648 cell NGTJe4tIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUDoZ4xSUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE3PDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkWxOVgzKM7:TR?= MUXTRW5ITVJ?
PF-382 cell MnrES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3vFPGlvcGmkaYTpc44hd2ZiaIXtZY4hWEZvM{iyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44ODd4MzFOwG0> MVnTRW5ITVJ?
human Daudi cell MoPBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlW2TY5pcWKrdHnvckBw\iCqdX3hckBF[XWmaTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|E1OTFizszN NX3BZYdiW0GQR1XS
SW982 cell M1e5Wmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1vKdWlvcGmkaYTpc44hd2ZiaIXtZY4hW1d7OEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg2QDF7IN88US=> NF;UXHFUSU6JRWK=
SW872 cell MlyzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEjoTHJKdmirYnn0bY9vKG:oIHj1cYFvKFOZOEeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE45PjR3ODFOwG0> M2[1fHNCVkeHUh?=
TE-12 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkO4TY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFg5OzFizszN M3HnZnNCVkeHUh?=
human HOP-62 cell M2\Rb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MW\Jcohq[mm2aX;uJI9nKGi3bXHuJGhQWC14MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPVE2QTlizszN MUTTRW5ITVJ?
human NOS-1 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4n0b2lvcGmkaYTpc44hd2ZiaIXtZY4hVk:VLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlk2ODR3IN88US=> NYnEPIM4W0GQR1XS
human BL-41 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlfDTY5pcWKrdHnvckBw\iCqdX3hckBDVC12MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFAxOTNizszN NX6zXmRMW0GQR1XS
human TGBC24TKB cell Mn\NS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnX5TY5pcWKrdHnvckBw\iCqdX3hckBVT0KFMkTUT2Ih[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB|OEOxJO69VQ>? M{PYTHNCVkeHUh?=
human KGN cell NGrpTmRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnnrTY5pcWKrdHnvckBw\iCqdX3hckBMT05iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkC1NlEh|ryP M{XEb3NCVkeHUh?=
human TK10 cell MknaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnXuTY5pcWKrdHnvckBw\iCqdX3hckBVUzFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wPFQyQCEQvF2= M3;me3NCVkeHUh?=
human GB-1 cell M3;kS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3fVWGlvcGmkaYTpc44hd2ZiaIXtZY4hT0JvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVYxPjRizszN MkPJV2FPT0WU
human GCIY cell NFnudmJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NITiXHFKdmirYnn0bY9vKG:oIHj1cYFvKEeFSWmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI{ODFizszN M4L1WXNCVkeHUh?=
human LXF-289 cell Ml3OS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3[4Z2lvcGmkaYTpc44hd2ZiaIXtZY4hVFiILUK4PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjd{NU[g{txO NEDObnlUSU6JRWK=
RL95-2 cell MkLZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEnJcGlKdmirYnn0bY9vKG:oIHj1cYFvKFKOOUWtNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOzJ2M{[g{txO MWjTRW5ITVJ?
human SW962 cell MoW4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoXOTY5pcWKrdHnvckBw\iCqdX3hckBUXzl4MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|M4PDJizszN M2PJb3NCVkeHUh?=
human HT-144 cell NUfW[4pwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mm\tTY5pcWKrdHnvckBw\iCqdX3hckBJXC1zNESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ1PTF5IN8ccS=> M4HCNXNCVkeHUh?=
human IST-SL2 cell M{TyS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXnJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2VTEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ4PDJzIN88US=> M4fC[3NCVkeHUh?=
human NB6 cell NUDQfZhpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mor4TY5pcWKrdHnvckBw\iCqdX3hckBPSjZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLk[5Olk5KM7:TR?= NEH4fW1USU6JRWK=
human SF126 cell MkDyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH\xRZZKdmirYnn0bY9vKG:oIHj1cYFvKFOIMUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU44OzF5ODFOwG0> M2H2PXNCVkeHUh?=
human BOKU cell NF;sb29Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVvXdIZwUW6qaXLpeIlwdiCxZjDoeY1idiCET1vVJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45ODV{NzFOwG0> MmrQV2FPT0WU
human BB30-HNC cell Mk\4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NW\rZZViUW6qaXLpeIlwdiCxZjDoeY1idiCEQkOwMWhPSyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwOEW0O|Ih|ryP MofRV2FPT0WU
human KLE cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mlr6TY5pcWKrdHnvckBw\iCqdX3hckBMVEViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLki2NlMzKM7:TR?= MX;TRW5ITVJ?
human MLMA cell MnTES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1XjTGlvcGmkaYTpc44hd2ZiaIXtZY4hVUyPQTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPVI{OSEQvF2= M1XuU3NCVkeHUh?=
human KINGS-1 cell MkLuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVrXToFLUW6qaXLpeIlwdiCxZjDoeY1idiCNSV7HV{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57Nki5O{DPxE1? NXT4eplsW0GQR1XS
human ES6 cell M4\l[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmnZTY5pcWKrdHnvckBw\iCqdX3hckBGWzZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkC1OFAyKM7:TR?= M1zEVnNCVkeHUh?=
human SH-4 cell M1\2b2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYXJcohq[mm2aX;uJI9nKGi3bXHuJHNJNTRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGyNFU2KM7:TR?= M3XyZ3NCVkeHUh?=
human D-263MG cell M2D6VGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1KyZWlvcGmkaYTpc44hd2ZiaIXtZY4hTC1{NkPNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjh6NUOg{txO NITwSoZUSU6JRWK=
human SF268 cell NV7PN4JZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUPVNYxTUW6qaXLpeIlwdiCxZjDoeY1idiCVRkK2PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPDh4OEKg{txO NH7FO2ZUSU6JRWK=
human NB17 cell NFPoPYJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnraTY5pcWKrdHnvckBw\iCqdX3hckBPSjF5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj62Nlg4PSEQvF2= M{TOTnNCVkeHUh?=
human DMS-114 cell M2HHRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXr4NFR2UW6qaXLpeIlwdiCxZjDoeY1idiCGTWOtNVE1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi55OUCyNkDPxE1? MYnTRW5ITVJ?
MC116 cell NXTNcnZTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGnicFhKdmirYnn0bY9vKG:oIHj1cYFvKE2FMUG2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk45PTdyNDFOwG0> NG\MOZpUSU6JRWK=
human NCI-H747 cell M4izZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml\kTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEe0O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzRzNUmg{txO M{TVeXNCVkeHUh?=
human A388 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHHXVpJKdmirYnn0bY9vKG:oIHj1cYFvKEF|OEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOE43PzV6IN88US=> NEXnRVdUSU6JRWK=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 12 mg/mL warmed (21.1 mM)
Water Insoluble
Ethanol ''6 mg/mL warmed
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
1mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 568.67
Formula

C32H36N6O4

CAS No. 837422-57-8
Storage powder
in solvent
Synonyms KIN001-112, KIN112
Smiles CC1=C(C(=CC=C1)C)OC(=O)N(C2=C(C=C(C=C2)OC)OC)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCN(CC5)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID