WH-4-023

For research use only.

Catalog No.S7565 Synonyms: KIN001-112, KIN112

7 publications

WH-4-023 Chemical Structure

Molecular Weight(MW): 568.67

WH-4-023 (KIN001-112, KIN112) is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.

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Selleck's WH-4-023 has been cited by 7 publications

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  • (G-I) WB analysis of total LCK, LCK Y505, and Src Y416 expression in ALL-SIL, CCRF-CEM, and TALL-1. Cells were treated with DMSO only (Ctrl), dasatinib, bosutinib, nintedanib, or WH-4-023 overnight at the compound concentrations corresponding to the GI50 at 48 hr. Bos, bosutinib; Das, dasatinib; Nint, nintedanib; WH, WH-4-023.

    Blood, 2017, 130(25):2750-2761. WH-4-023 purchased from Selleck.

Purity & Quality Control

Choose Selective Src Inhibitors

Biological Activity

Description WH-4-023 (KIN001-112, KIN112) is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.
Targets
Lck [1]
(Cell-free assay)
Src [1]
(Cell-free assay)
2 nM 6 nM
In vitro

WH-4-023 shows little activity on p38 and KDR. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human EM-2 cell NVnVO|N3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoXETY5pcWKrdHnvckBw\iCqdX3hckBGVS1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz65NYUuODhizszN NUm0VpRGW0GQR1XS
human LAMA-84 cell NWTDWWtlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmPnTY5pcWKrdHnvckBw\iCqdX3hckBNSU2DLUi0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{44QGVvME[g{txO NHf6eXhUSU6JRWK=
human EoL-1-cell cell NV3leGE6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3HUdGlvcGmkaYTpc44hd2ZiaIXtZY4hTW:OLUGtZ4VtdCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTlwNUHlMVA3KM7:TR?= NEHFR2xUSU6JRWK=
human MEG-01 cell NHLMWmtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEnzWm1KdmirYnn0bY9vKG:oIHj1cYFvKE2HRz2wNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjOnLUC1JO69VQ>? NYrNfY9UW0GQR1XS
human CTV-1 cell NXToRVJKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnnLTY5pcWKrdHnvckBw\iCqdX3hckBEXFZvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNVhmNTB3IN88US=> MofDV2FPT0WU
human BL-70 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWTJcohq[mm2aX;uJI9nKGi3bXHuJGJNNTdyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND63NoUuODVizszN NHmwRZhUSU6JRWK=
human K-562 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEXNeWFKdmirYnn0bY9vKG:oIHj1cYFvKEtvNU[yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xODBzNkKg{txO NFr6cYhUSU6JRWK=
human BV-173 cell M1nBbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3\GV2lvcGmkaYTpc44hd2ZiaIXtZY4hSlZvMUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xODB3MUSg{txO NYDweYZKW0GQR1XS
human DOHH-2 cell NWDnSnplT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVnJcohq[mm2aX;uJI9nKGi3bXHuJGRQUEhvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNFAxPTl5IN88US=> NXPwXWtQW0GQR1XS
human A704 cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnfBTY5pcWKrdHnvckBw\iCqdX3hckBCPzB2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wNFEzPyEQvF2= NVXIb25rW0GQR1XS
human NCI-SNU-16 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV[wdGRFUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtV25WNTF4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wNVU4OiEQvF2= MVzTRW5ITVJ?
human LC-2-ad cell MmnvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFzXSmdKdmirYnn0bY9vKG:oIHj1cYFvKEyFLUKtZYQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB{MEOzJO69VQ>? MUfTRW5ITVJ?
human LB2518-MEL cell NYP4PGIyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH;kU4JKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkWxPE1OTUxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkC0OlY4KM7:TR?= NXTvVFZ2W0GQR1XS
human D-336MG cell NY\6RmZbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWTpfW9JUW6qaXLpeIlwdiCxZjDoeY1idiCGLUOzOm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yNE[4NUDPxE1? MV7TRW5ITVJ?
human LB996-RCC cell MkjVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX;aOZBmUW6qaXLpeIlwdiCxZjDoeY1idiCOQkm5Ok1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkC1OlY5KM7:TR?= M4XrOHNCVkeHUh?=
human Becker cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYfVUGsxUW6qaXLpeIlwdiCxZjDoeY1idiCEZXPr[ZIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB4M{ixJO69VQ>? NFX3OZlUSU6JRWK=
human LB1047-RCC cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH20[I1KdmirYnn0bY9vKG:oIHj1cYFvKEyEMUC0O{1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkC3OVkzKM7:TR?= NHnRT3FUSU6JRWK=
human KS-1 cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4XYfGlvcGmkaYTpc44hd2ZiaIXtZY4hU1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNFc4PThizszN NFGz[opUSU6JRWK=
human MPP-89 cell MmnTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV:5cWRrUW6qaXLpeIlwdiCxZjDoeY1idiCPUGCtPFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB6MkK5JO69VQ>? NVzKWoJmW0GQR1XS
human RXF393 cell M1vJSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoTETY5pcWKrdHnvckBw\iCqdX3hckBTYEZ|OUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlExPjN|IN88US=> MWfTRW5ITVJ?
LB831-BLC cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnjWTY5pcWKrdHnvckBw\iCqdX3hckBNSjh|MT3CUGMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjF{N{G1JO69VQ>? MljuV2FPT0WU
HUTU-80 cell NYjmN|lOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUGzWpp[UW6qaXLpeIlwdiCxZjDoeY1idiCKVWTVMVgxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5zN{WyPUDPxE1? M3f3c3NCVkeHUh?=
A498 cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXu1fFdNUW6qaXLpeIlwdiCxZjDoeY1idiCDNEm4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yQDl2NTFOwG0> NFHwU3RUSU6JRWK=
MZ1-PC cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWnJcohq[mm2aX;uJI9nKGi3bXHuJG1bOS2SQzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNlI4OTZizszN Mn\jV2FPT0WU
TE-8 cell MmjhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkS1TY5pcWKrdHnvckBw\iCqdX3hckBVTS16IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yN|kzPCEQvF2= M1e0VHNCVkeHUh?=
MFH-ino cell  NETme45Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mki0TY5pcWKrdHnvckBw\iCqdX3hckBOTkhvaX7vJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4zOzl{NTFOwG0> NInQXZNUSU6JRWK=
TE-15 cell MoHhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXrIVWY4UW6qaXLpeIlwdiCxZjDoeY1idiCWRT2xOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOjR{N{[g{txO M4rzRXNCVkeHUh?=
NTERA-S-cl-D1 cell NVnySXBoT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUTJcohq[mm2aX;uJI9nKGi3bXHuJG5VTVKDLWOtZ4wuTDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkK4PFU2KM7:TR?= MlLQV2FPT0WU
COLO-829 cell NULNdXJXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M320PGlvcGmkaYTpc44hd2ZiaIXtZY4hS0:OTz24Nlkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjNzMkGyJO69VQ>? NX;VbmRlW0GQR1XS
SW684 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF7MR3hKdmirYnn0bY9vKG:oIHj1cYFvKFOZNki0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{OjV6ODFOwG0> MY\TRW5ITVJ?
OS-RC-2 cell NUjyOWxiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NW\a[pl{UW6qaXLpeIlwdiCxZjDoeY1idiCRUz3SR{0zKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5|NUCxNUDPxE1? MUPTRW5ITVJ?
IST-MES1 cell MkfKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH7nb2RKdmirYnn0bY9vKG:oIHj1cYFvKEmVVD3NSXMyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5|NUeyN{DPxE1? Mk\0V2FPT0WU
SNB75 cell MkXYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mom0TY5pcWKrdHnvckBw\iCqdX3hckBUVkJ5NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuN|U4PzRizszN NE\tfmpUSU6JRWK=
SW954 cell NVvHVVZHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVr4UWl6UW6qaXLpeIlwdiCxZjDoeY1idiCVV{m1OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOzdzNkOg{txO NYrIT4JoW0GQR1XS
RCC10RGB cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2XJb2lvcGmkaYTpc44hd2ZiaIXtZY4hWkOFMUDSS2Ih[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjR{NkOxJO69VQ>? M4ntNXNCVkeHUh?=
VA-ES-BJ cell Mn[xS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYj0NHN2UW6qaXLpeIlwdiCxZjDoeY1idiCYQT3FV{1DUiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwNE[yOkDPxE1? NWHQVZhGW0GQR1XS
NCI-H1648 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml;iTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG2OFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjVzNUiyJO69VQ>? NGW5coFUSU6JRWK=
PF-382 cell NVTQ[np7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHS0e3dKdmirYnn0bY9vKG:oIHj1cYFvKFCILUO4NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzB5NkOg{txO MmnMV2FPT0WU
human Daudi cell M4f1O2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoOyTY5pcWKrdHnvckBw\iCqdX3hckBF[XWmaTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|E1OTFizszN NVLTeW9RW0GQR1XS
SW982 cell NV;yRlR4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYf4UmhoUW6qaXLpeIlwdiCxZjDoeY1idiCVV{m4NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQDV6MUmg{txO NEXjOmpUSU6JRWK=
SW872 cell M33qRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnfmTY5pcWKrdHnvckBw\iCqdX3hckBUXzh5MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFY1PThizszN MUPTRW5ITVJ?
TE-12 cell MlSyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnK4TY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFg5OzFizszN NGnTVHZUSU6JRWK=
human HOP-62 cell M2P2fWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGXXXY5KdmirYnn0bY9vKG:oIHj1cYFvKEiRUD22NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTF3OUmg{txO M{W1UnNCVkeHUh?=
human NOS-1 cell NGjw[m5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml;aTY5pcWKrdHnvckBw\iCqdX3hckBPV1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPVUxPDVizszN NIPR[lFUSU6JRWK=
human BL-41 cell MnHZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mo\tTY5pcWKrdHnvckBw\iCqdX3hckBDVC12MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFAxOTNizszN NXXWVnhtW0GQR1XS
human TGBC24TKB cell MlTsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVT1boYxUW6qaXLpeIlwdiCxZjDoeY1idiCWR1LDNlRVU0JiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkCzPFMyKM7:TR?= MmLuV2FPT0WU
human KGN cell M1vMTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIiy[YVKdmirYnn0bY9vKG:oIHj1cYFvKEuJTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFUzOSEQvF2= NU\FfFI1W0GQR1XS
human TK10 cell Mnq5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX;Jcohq[mm2aX;uJI9nKGi3bXHuJHRMOTBiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkC4OFE5KM7:TR?= MYrTRW5ITVJ?
human GB-1 cell MnLES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MljsTY5pcWKrdHnvckBw\iCqdX3hckBISi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xOlA3PCEQvF2= MnXVV2FPT0WU
human GCIY cell M3nqVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnPLTY5pcWKrdHnvckBw\iCqdX3hckBIS0m\IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6yN|AyKM7:TR?= MVjTRW5ITVJ?
human LXF-289 cell Mkm4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mm\STY5pcWKrdHnvckBw\iCqdX3hckBNYEZvMki5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zPzJ3NjFOwG0> NG\nPY9USU6JRWK=
RL95-2 cell M{[4cGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1TYZmlvcGmkaYTpc44hd2ZiaIXtZY4hWkx7NT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{OjR|NjFOwG0> MkmwV2FPT0WU
human SW962 cell MmPVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mmj0TY5pcWKrdHnvckBw\iCqdX3hckBUXzl4MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|M4PDJizszN NF\HUnZUSU6JRWK=
human HT-144 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUm4eoFRUW6qaXLpeIlwdiCxZjDoeY1idiCKVD2xOFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjR2NUG3JO6ddQ>? NVvnd2JsW0GQR1XS
human IST-SL2 cell Mnq0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX7Jcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2VTEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ4PDJzIN88US=> NVr4dW5GW0GQR1XS
human NB6 cell NFTWbYNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnHLTY5pcWKrdHnvckBw\iCqdX3hckBPSjZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLk[5Olk5KM7:TR?= NXm3T|k{W0GQR1XS
human SF126 cell NVLNcFBNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MorTTY5pcWKrdHnvckBw\iCqdX3hckBUTjF{NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|MyPzhizszN MX3TRW5ITVJ?
human BOKU cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGXFN5ZKdmirYnn0bY9vKG:oIHj1cYFvKEKRS2WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlgxPTJ5IN88US=> M1\4OnNCVkeHUh?=
human BB30-HNC cell M{XvN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXfJVY95UW6qaXLpeIlwdiCxZjDoeY1idiCEQkOwMWhPSyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwOEW0O|Ih|ryP NHzoOmdUSU6JRWK=
human KLE cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX;Jcohq[mm2aX;uJI9nKGi3bXHuJGtNTSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwOE[yN|Ih|ryP M3\3XHNCVkeHUh?=
human MLMA cell MkDVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIDMUnlKdmirYnn0bY9vKG:oIHj1cYFvKE2OTVGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlkzOzFizszN NYnZN4JqW0GQR1XS
human KINGS-1 cell Mnr1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlHsTY5pcWKrdHnvckBw\iCqdX3hckBMUU6JUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46Pjh7NzFOwG0> Ml;FV2FPT0WU
human ES6 cell NIOySmhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUTQO|VtUW6qaXLpeIlwdiCxZjDoeY1idiCHU{[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlA2PDBzIN88US=> MoHmV2FPT0WU
human SH-4 cell M1i4V2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVXNWJFiUW6qaXLpeIlwdiCxZjDoeY1idiCVSD20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yOjB3NTFOwG0> NW\HU5NIW0GQR1XS
human D-263MG cell MnnzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIrMfIFKdmirYnn0bY9vKG:oIHj1cYFvKERvMk[zUWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ6OEWzJO69VQ>? NWS5RXJzW0GQR1XS
human SF268 cell MkHWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYPJcohq[mm2aX;uJI9nKGi3bXHuJHNHOjZ6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj60PFY5OiEQvF2= M4G3[nNCVkeHUh?=
human NB17 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWfJcohq[mm2aX;uJI9nKGi3bXHuJG5DOTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[yPFc2KM7:TR?= MkLDV2FPT0WU
human DMS-114 cell NELtdo5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlToTY5pcWKrdHnvckBw\iCqdX3hckBFVVNvMUG0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44QTB{MjFOwG0> MV3TRW5ITVJ?
MC116 cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXLJcohq[mm2aX;uJI9nKGi3bXHuJG1EOTF4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj64OVcxPCEQvF2= MYLTRW5ITVJ?
human NCI-H747 cell MlPGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXnJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KN{S3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU44PDF3OTFOwG0> M{jDdXNCVkeHUh?=
human A388 cell NVn5WFRxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1TBSWlvcGmkaYTpc44hd2ZiaIXtZY4hSTN6ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG0MlY4PThizszN NYrXdlhvW0GQR1XS

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 12 mg/mL warmed (21.1 mM)
Water Insoluble
Ethanol ''6 mg/mL warmed
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
1mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 568.67
Formula

C32H36N6O4

CAS No. 837422-57-8
Storage powder
in solvent
Synonyms KIN001-112, KIN112
Smiles CC1=C(C(=CC=C1)C)OC(=O)N(C2=C(C=C(C=C2)OC)OC)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCN(CC5)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID