WH-4-023

For research use only.

Catalog No.S7565 Synonyms: KIN001-112, KIN112

7 publications

WH-4-023 Chemical Structure

CAS No. 837422-57-8

WH-4-023 (KIN001-112, KIN112) is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.

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Selleck's WH-4-023 has been cited by 7 publications

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  • (G-I) WB analysis of total LCK, LCK Y505, and Src Y416 expression in ALL-SIL, CCRF-CEM, and TALL-1. Cells were treated with DMSO only (Ctrl), dasatinib, bosutinib, nintedanib, or WH-4-023 overnight at the compound concentrations corresponding to the GI50 at 48 hr. Bos, bosutinib; Das, dasatinib; Nint, nintedanib; WH, WH-4-023.

    Blood, 2017, 130(25):2750-2761. WH-4-023 purchased from Selleck.

Purity & Quality Control

Choose Selective Src Inhibitors

Biological Activity

Description WH-4-023 (KIN001-112, KIN112) is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.
Targets
Lck [1]
(Cell-free assay)
Src [1]
(Cell-free assay)
2 nM 6 nM
In vitro

WH-4-023 shows little activity on p38 and KDR. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human EM-2 cell NVHYZXo4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUPJcohq[mm2aX;uJI9nKGi3bXHuJGVONTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|Lkmx[U0xQCEQvF2= MVLTRW5ITVJ?
human LAMA-84 cell NHv0U5RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MonvTY5pcWKrdHnvckBw\iCqdX3hckBNSU2DLUi0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{44QGVvME[g{txO Ml3mV2FPT0WU
human EoL-1-cell cell NFzDdYZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVLJcohq[mm2aX;uJI9nKGi3bXHuJGVwVC1zLXPlcIwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06NjVzZT2wOkDPxE1? NEHPRlNUSU6JRWK=
human MEG-01 cell MofxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1vWRWlvcGmkaYTpc44hd2ZiaIXtZY4hVUWJLUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43O2VvMEWg{txO NVW1fHcyW0GQR1XS
human CTV-1 cell NUXkemtGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWj3Znk4UW6qaXLpeIlwdiCxZjDoeY1idiCFVG[tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvOTinLUC1JO69VQ>? MV7TRW5ITVJ?
human BL-70 cell NVn2N4RtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NETuR|hKdmirYnn0bY9vKG:oIHj1cYFvKEKOLUewJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE44OmVvMEWg{txO NGHvSIVUSU6JRWK=
human K-562 cell Ml:4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2Xue2lvcGmkaYTpc44hd2ZiaIXtZY4hUy13NkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlAxODF4MjFOwG0> MX7TRW5ITVJ?
human BV-173 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGPXfppKdmirYnn0bY9vKG:oIHj1cYFvKEKYLUG3N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODByNUG0JO69VQ>? NGTwVlJUSU6JRWK=
human DOHH-2 cell NWW5c5JnT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoLnTY5pcWKrdHnvckBw\iCqdX3hckBFV0iKLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlAxODV7NzFOwG0> NWOySIxsW0GQR1XS
human A704 cell NUnCdpNMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mo\lTY5pcWKrdHnvckBw\iCqdX3hckBCPzB2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wNFEzPyEQvF2= NEi0RmtUSU6JRWK=
human NCI-SNU-16 cell MoLtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn;2TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvU17VMVE3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yMUW3NkDPxE1? NGTje2lUSU6JRWK=
human LC-2-ad cell NIH0fpBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NED2NnlKdmirYnn0bY9vKG:oIHj1cYFvKEyFLUKtZYQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB{MEOzJO69VQ>? M3\QfHNCVkeHUh?=
human LB2518-MEL cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF73VVVKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkWxPE1OTUxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkC0OlY4KM7:TR?= NYT3dIRRW0GQR1XS
human D-336MG cell M3fKRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoPuTY5pcWKrdHnvckBw\iCqdX3hckBFNTN|Nl3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xPDZ6MTFOwG0> MlPQV2FPT0WU
human LB996-RCC cell NICwWYlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFi2XWxKdmirYnn0bY9vKG:oIHj1cYFvKEyEOUm2MXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMEW2Olgh|ryP MY\TRW5ITVJ?
human Becker cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnXMTY5pcWKrdHnvckBw\iCqdX3hckBD\WOtZYKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlA3OzhzIN88US=> NWjHVIFkW0GQR1XS
human LB1047-RCC cell NEnwUlZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEn5dIhKdmirYnn0bY9vKG:oIHj1cYFvKEyEMUC0O{1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkC3OVkzKM7:TR?= MVXTRW5ITVJ?
human KS-1 cell MnH0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml20TY5pcWKrdHnvckBw\iCqdX3hckBMWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wO|c2QCEQvF2= NGfYXpRUSU6JRWK=
human MPP-89 cell MoC0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUHrU5pEUW6qaXLpeIlwdiCxZjDoeY1idiCPUGCtPFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB6MkK5JO69VQ>? NIS5WnJUSU6JRWK=
human RXF393 cell NGSyPGtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{TBdmlvcGmkaYTpc44hd2ZiaIXtZY4hWliIM{mzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yODZ|MzFOwG0> MlPqV2FPT0WU
LB831-BLC cell MnT2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3Lue2lvcGmkaYTpc44hd2ZiaIXtZY4hVEJ6M{GtRmxEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5zMkexOUDPxE1? NYDET4xGW0GQR1XS
HUTU-80 cell M4nFOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2PsT2lvcGmkaYTpc44hd2ZiaIXtZY4hUFWWVT24NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTd3Mkmg{txO MUXTRW5ITVJ?
A498 cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWPJcohq[mm2aX;uJI9nKGi3bXHuJGE1QThiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkG4PVQ2KM7:TR?= NX64bYlNW0GQR1XS
MZ1-PC cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVfJcohq[mm2aX;uJI9nKGi3bXHuJG1bOS2SQzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNlI4OTZizszN M1r3OHNCVkeHUh?=
TE-8 cell M2foe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkPOTY5pcWKrdHnvckBw\iCqdX3hckBVTS16IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yN|kzPCEQvF2= MnO1V2FPT0WU
MFH-ino cell  M3S0V2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWe1cXBOUW6qaXLpeIlwdiCxZjDoeY1idiCPRlitbY5wKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5{M{myOUDPxE1? Ml\iV2FPT0WU
TE-15 cell Mlr2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{fpZ2lvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlI1Ojd4IN88US=> MonWV2FPT0WU
NTERA-S-cl-D1 cell M2Lv[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHW5PINKdmirYnn0bY9vKG:oIHj1cYFvKE6WRWLBMXMu[2xvREGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlI5QDV3IN88US=> MnHnV2FPT0WU
COLO-829 cell MmXBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXvpcZNQUW6qaXLpeIlwdiCxZjDoeY1idiCFT1zPMVgzQSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwM{GyNVIh|ryP NXfKNmpOW0GQR1XS
SW684 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXrxVmZRUW6qaXLpeIlwdiCxZjDoeY1idiCVV{[4OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOzJ3OEig{txO MW\TRW5ITVJ?
OS-RC-2 cell MmC4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUXuTpNNUW6qaXLpeIlwdiCxZjDoeY1idiCRUz3SR{0zKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5|NUCxNUDPxE1? NVTvdpN5W0GQR1XS
IST-MES1 cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4POdWlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLV3FV|Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjN3N{KzJO69VQ>? NHXUPGVUSU6JRWK=
SNB75 cell M2LVXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXLJcohq[mm2aX;uJI9nKGi3bXHuJHNPSjd3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6zOVc4PCEQvF2= MnnNV2FPT0WU
SW954 cell NWK0XJhGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnPnTY5pcWKrdHnvckBw\iCqdX3hckBUXzl3NDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuN|cyPjNizszN NWnUXnF2W0GQR1XS
RCC10RGB cell NHzheoFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEnaZpdKdmirYnn0bY9vKG:oIHj1cYFvKFKFQ{GwVmdDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC52Mk[zNUDPxE1? NGPoeGlUSU6JRWK=
VA-ES-BJ cell NGXXRnJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mk\mTY5pcWKrdHnvckBw\iCqdX3hckBXSS2HUz3CTkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPDZ{NjFOwG0> M{j4WnNCVkeHUh?=
NCI-H1648 cell M3vnOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkX2TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG2OFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjVzNUiyJO69VQ>? NX7hSnI5W0GQR1XS
PF-382 cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGTvSnBKdmirYnn0bY9vKG:oIHj1cYFvKFCILUO4NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzB5NkOg{txO M4\n[nNCVkeHUh?=
human Daudi cell NHPpUI5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUfJcohq[mm2aX;uJI9nKGi3bXHuJGRifWSrIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD63NVQyOSEQvF2= M{LleXNCVkeHUh?=
SW982 cell NYDTeol6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFz6OYJKdmirYnn0bY9vKG:oIHj1cYFvKFOZOUiyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE45PThzOTFOwG0> MX\TRW5ITVJ?
SW872 cell NIS2[Y9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3fHUGlvcGmkaYTpc44hd2ZiaIXtZY4hW1d6N{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg3PDV6IN88US=> MkHHV2FPT0WU
TE-12 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXvJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64PFg{OSEQvF2= NWixdJRxW0GQR1XS
human HOP-62 cell MkLYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoLVTY5pcWKrdHnvckBw\iCqdX3hckBJV1BvNkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlkyPTl7IN88US=> NUHlTZVmW0GQR1XS
human NOS-1 cell M{PJSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3n0SmlvcGmkaYTpc44hd2ZiaIXtZY4hVk:VLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlk2ODR3IN88US=> M{LGT3NCVkeHUh?=
human BL-41 cell NYPaWod1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX3Jcohq[mm2aX;uJI9nKGi3bXHuJGJNNTRzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wNFAyOyEQvF2= NFzIR21USU6JRWK=
human TGBC24TKB cell NXXRelZrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWrpRphJUW6qaXLpeIlwdiCxZjDoeY1idiCWR1LDNlRVU0JiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkCzPFMyKM7:TR?= M{jaS3NCVkeHUh?=
human KGN cell M37y[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVLsTGh4UW6qaXLpeIlwdiCxZjDoeY1idiCNR16gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA2OjFizszN M{frZnNCVkeHUh?=
human TK10 cell MkHxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NY\MRnFRUW6qaXLpeIlwdiCxZjDoeY1idiCWS{GwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xQDRzODFOwG0> MlnuV2FPT0WU
human GB-1 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV24TGQ6UW6qaXLpeIlwdiCxZjDoeY1idiCJQj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPjB4NDFOwG0> MmjHV2FPT0WU
human GCIY cell MmXSS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{TT[WlvcGmkaYTpc44hd2ZiaIXtZY4hT0OLWTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNlMxOSEQvF2= M2jjbHNCVkeHUh?=
human LXF-289 cell M3HOOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX;Jcohq[mm2aX;uJI9nKGi3bXHuJGxZTi1{OEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI4OjV4IN88US=> MkLhV2FPT0WU
RL95-2 cell NHzmdmNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlG5TY5pcWKrdHnvckBw\iCqdX3hckBTVDl3LUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlMzPDN4IN88US=> M1;Vc3NCVkeHUh?=
human SW962 cell MlPOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVXJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTZ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zN|c1OiEQvF2= NX7DeYVOW0GQR1XS
human HT-144 cell NEfZWm9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVLJcohq[mm2aX;uJI9nKGi3bXHuJGhVNTF2NDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFQ2OTdizqzt M2nTdHNCVkeHUh?=
human IST-SL2 cell NGXzUmJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX;YemZJUW6qaXLpeIlwdiCxZjDoeY1idiCLU2StV2wzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS52N{SyNUDPxE1? MYHTRW5ITVJ?
human NB6 cell NWPWPJo4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXLJXJREUW6qaXLpeIlwdiCxZjDoeY1idiCQQk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlY6Pjl6IN88US=> M1Hme3NCVkeHUh?=
human SF126 cell Mn[yS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVXDSm1LUW6qaXLpeIlwdiCxZjDoeY1idiCVRkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPzNzN{ig{txO NUDXT405W0GQR1XS
human BOKU cell M1PhUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoHnTY5pcWKrdHnvckBw\iCqdX3hckBDV0uXIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT64NFUzPyEQvF2= NETRXoVUSU6JRWK=
human BB30-HNC cell M1\zWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmHOTY5pcWKrdHnvckBw\iCqdX3hckBDSjNyLVjOR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQDV2N{Kg{txO NHPZfpBUSU6JRWK=
human KLE cell NFPx[3JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV\Jcohq[mm2aX;uJI9nKGi3bXHuJGtNTSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwOE[yN|Ih|ryP MoPmV2FPT0WU
human MLMA cell M4rocGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{C2SGlvcGmkaYTpc44hd2ZiaIXtZY4hVUyPQTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPVI{OSEQvF2= NWnER3R5W0GQR1XS
human KINGS-1 cell NYnQfJlsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVjJcohq[mm2aX;uJI9nKGi3bXHuJGtKVkeVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlk3QDl5IN88US=> NHzFNYRUSU6JRWK=
human ES6 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MknXTY5pcWKrdHnvckBw\iCqdX3hckBGWzZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkC1OFAyKM7:TR?= NIXYcpFUSU6JRWK=
human SH-4 cell NV;mPVNRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2iyWGlvcGmkaYTpc44hd2ZiaIXtZY4hW0hvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVIxPTVizszN NWGzRpQ5W0GQR1XS
human D-263MG cell M3jUSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIixd3hKdmirYnn0bY9vKG:oIHj1cYFvKERvMk[zUWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ6OEWzJO69VQ>? M2jHOXNCVkeHUh?=
human SF268 cell NIO2[mFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn7aTY5pcWKrdHnvckBw\iCqdX3hckBUTjJ4ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOFg3QDJizszN MkGyV2FPT0WU
human NB17 cell MoHmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHXVNWRKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlYzQDd3IN88US=> Mn;SV2FPT0WU
human DMS-114 cell NWnLXFUzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1XM[GlvcGmkaYTpc44hd2ZiaIXtZY4hTE2VLUGxOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzlyMkKg{txO MofxV2FPT0WU
MC116 cell NF;yUlZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIH6O4FKdmirYnn0bY9vKG:oIHj1cYFvKE2FMUG2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk45PTdyNDFOwG0> NX2x[ncxW0GQR1XS
human NCI-H747 cell NUjWfZBYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX7Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KN{S3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU44PDF3OTFOwG0> M{HFUXNCVkeHUh?=
human A388 cell M1vLPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MknwTY5pcWKrdHnvckBw\iCqdX3hckBCOzh6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUSuOlc2QCEQvF2= M1TzbHNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 12 mg/mL warmed (21.1 mM)
Ethanol 6 mg/mL warmed (10.55 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
1mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 568.67
Formula

C32H36N6O4

CAS No. 837422-57-8
Storage powder
in solvent
Synonyms KIN001-112, KIN112
Smiles CC1=C(C(=CC=C1)C)OC(=O)N(C2=C(C=C(C=C2)OC)OC)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCN(CC5)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Src Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID