WH-4-023

For research use only. Not for use in humans.

Catalog No.S7565 Synonyms: KIN001-112, KIN112

4 publications

WH-4-023 Chemical Structure

Molecular Weight(MW): 568.67

WH-4-023 is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.

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Selleck's WH-4-023 has been cited by 4 publications

1 Customer Review

  • (G-I) WB analysis of total LCK, LCK Y505, and Src Y416 expression in ALL-SIL, CCRF-CEM, and TALL-1. Cells were treated with DMSO only (Ctrl), dasatinib, bosutinib, nintedanib, or WH-4-023 overnight at the compound concentrations corresponding to the GI50 at 48 hr. Bos, bosutinib; Das, dasatinib; Nint, nintedanib; WH, WH-4-023.

    Blood, 2017, 130(25):2750-2761. WH-4-023 purchased from Selleck.

Purity & Quality Control

Choose Selective Src Inhibitors

Biological Activity

Description WH-4-023 is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.
Targets
Lck [1]
(Cell-free assay)
Src [1]
(Cell-free assay)
2 nM 6 nM
In vitro

WH-4-023 shows little activity on p38 and KDR. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human EM-2 cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIfSc|hKdmirYnn0bY9vKG:oIHj1cYFvKEWPLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlky\S1yODFOwG0> M{G5eXNCVkeHUh?=
human LAMA-84 cell NWHBTppFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnnxTY5pcWKrdHnvckBw\iCqdX3hckBNSU2DLUi0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{44QGVvME[g{txO MlTlV2FPT0WU
human EoL-1-cell cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkTSTY5pcWKrdHnvckBw\iCqdX3hckBGd0xvMT3j[YxtKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QS53MXWtNFYh|ryP MnnsV2FPT0WU
human MEG-01 cell M1zMSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mni2TY5pcWKrdHnvckBw\iCqdX3hckBOTUdvMEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlY{\S1yNTFOwG0> Ml;RV2FPT0WU
human CTV-1 cell NYHSfI17T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVXJcohq[mm2aX;uJI9nKGi3bXHuJGNVXi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6xPIUuODVizszN Mn7GV2FPT0WU
human BL-70 cell Mlv4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmnnTY5pcWKrdHnvckBw\iCqdX3hckBDVC15MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuO|JmNTB3IN88US=> MoH2V2FPT0WU
human K-562 cell M2K3Nmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4r4RmlvcGmkaYTpc44hd2ZiaIXtZY4hUy13NkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlAxODF4MjFOwG0> NFHLfXlUSU6JRWK=
human BV-173 cell M17uW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3yyZ2lvcGmkaYTpc44hd2ZiaIXtZY4hSlZvMUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xODB3MUSg{txO NH:1[YZUSU6JRWK=
human DOHH-2 cell M2naOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVzpTmoxUW6qaXLpeIlwdiCxZjDoeY1idiCGT1jIMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjByMEW5O{DPxE1? MlHvV2FPT0WU
human A704 cell MkHJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXfJcohq[mm2aX;uJI9nKGi3bXHuJGE4ODRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkCwNVI4KM7:TR?= M3fn[3NCVkeHUh?=
human NCI-SNU-16 cell MmrVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWjuWHE4UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtV25WNTF4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wNVU4OiEQvF2= NWS2b4tyW0GQR1XS
human LC-2-ad cell NXnHR2l[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWHJVJR7UW6qaXLpeIlwdiCxZjDoeY1idiCOQz2yMYFlKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yMkCzN{DPxE1? NHvsWllUSU6JRWK=
human LB2518-MEL cell M2HJe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MonDTY5pcWKrdHnvckBw\iCqdX3hckBNSjJ3MUitUWVNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yNE[2O{DPxE1? MWfTRW5ITVJ?
human D-336MG cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MknDTY5pcWKrdHnvckBw\iCqdX3hckBFNTN|Nl3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xPDZ6MTFOwG0> MXHTRW5ITVJ?
human LB996-RCC cell NH73XGtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHK3V45KdmirYnn0bY9vKG:oIHj1cYFvKEyEOUm2MXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMEW2Olgh|ryP NXvO[5R5W0GQR1XS
human Becker cell M1Xp[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mn3pTY5pcWKrdHnvckBw\iCqdX3hckBD\WOtZYKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlA3OzhzIN88US=> NV;keHJvW0GQR1XS
human LB1047-RCC cell NGnISm1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFrJRVVKdmirYnn0bY9vKG:oIHj1cYFvKEyEMUC0O{1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkC3OVkzKM7:TR?= NUDydJRUW0GQR1XS
human KS-1 cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MY\Jcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkC3O|U5KM7:TR?= M1vze3NCVkeHUh?=
human MPP-89 cell NHi2d2NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVfJcohq[mm2aX;uJI9nKGi3bXHuJG1RWC16OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNFgzOjlizszN MWHTRW5ITVJ?
human RXF393 cell NX3wXlN2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGDQZWlKdmirYnn0bY9vKG:oIHj1cYFvKFK[RkO5N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTB4M{Og{txO M3PSPXNCVkeHUh?=
LB831-BLC cell M{fnRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYPJcohq[mm2aX;uJI9nKGi3bXHuJGxDQDNzLVLMR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTJ5MUWg{txO MnvBV2FPT0WU
HUTU-80 cell NGjreIdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVfhO|B[UW6qaXLpeIlwdiCxZjDoeY1idiCKVWTVMVgxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5zN{WyPUDPxE1? NXvySpExW0GQR1XS
A498 cell MnXtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUK2ZlBCUW6qaXLpeIlwdiCxZjDoeY1idiCDNEm4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yQDl2NTFOwG0> MXXTRW5ITVJ?
MZ1-PC cell NEjyeolIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4nlRmlvcGmkaYTpc44hd2ZiaIXtZY4hVVpzLWDDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4zOjdzNjFOwG0> MoDqV2FPT0WU
TE-8 cell NHTIPJlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVjJcohq[mm2aX;uJI9nKGi3bXHuJHRGNThiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkKzPVI1KM7:TR?= MoLrV2FPT0WU
MFH-ino cell  M1f2TGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGfSVFRKdmirYnn0bY9vKG:oIHj1cYFvKE2ISD3pco8h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjJ|OUK1JO69VQ>? NVjDfFgzW0GQR1XS
TE-15 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{nCRmlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlI1Ojd4IN88US=> MXvTRW5ITVJ?
NTERA-S-cl-D1 cell M{\ldWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYDOe4U5UW6qaXLpeIlwdiCxZjDoeY1idiCQVFXSRU1UNWOuLVSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4zQDh3NTFOwG0> M3XTenNCVkeHUh?=
COLO-829 cell M13MZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2[zbWlvcGmkaYTpc44hd2ZiaIXtZY4hS0:OTz24Nlkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjNzMkGyJO69VQ>? M4DPbnNCVkeHUh?=
SW684 cell M{LV[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIH3Oo9KdmirYnn0bY9vKG:oIHj1cYFvKFOZNki0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{OjV6ODFOwG0> MnfqV2FPT0WU
OS-RC-2 cell M4n4XWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUHJcohq[mm2aX;uJI9nKGi3bXHuJG9UNVKFLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlM2ODFzIN88US=> MWjTRW5ITVJ?
IST-MES1 cell NHe3c4hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M16wUGlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLV3FV|Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjN3N{KzJO69VQ>? NV;rSI9WW0GQR1XS
SNB75 cell M{jwNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVvJcohq[mm2aX;uJI9nKGi3bXHuJHNPSjd3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6zOVc4PCEQvF2= NEjTTW9USU6JRWK=
SW954 cell Mly4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHL4ZpNKdmirYnn0bY9vKG:oIHj1cYFvKFOZOUW0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{PzF4MzFOwG0> MUXTRW5ITVJ?
RCC10RGB cell NEH0cGZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3nFSmlvcGmkaYTpc44hd2ZiaIXtZY4hWkOFMUDSS2Ih[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjR{NkOxJO69VQ>? NVzI[lZCW0GQR1XS
VA-ES-BJ cell M2j6NWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWq5NZJOUW6qaXLpeIlwdiCxZjDoeY1idiCYQT3FV{1DUiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwNE[yOkDPxE1? NH\xeIJUSU6JRWK=
NCI-H1648 cell NYe1PIRwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2DZSmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlQ5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC53MUW4NkDPxE1? MoXzV2FPT0WU
PF-382 cell NUPvSHBXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVP6XIZtUW6qaXLpeIlwdiCxZjDoeY1idiCSRj2zPFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjdyN{[zJO69VQ>? NWHOeXF6W0GQR1XS
human Daudi cell M2C0WGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoXLTY5pcWKrdHnvckBw\iCqdX3hckBF[XWmaTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|E1OTFizszN NVnzZZdEW0GQR1XS
SW982 cell NHPyZWNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH7EPXpKdmirYnn0bY9vKG:oIHj1cYFvKFOZOUiyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE45PThzOTFOwG0> NWW4O2lJW0GQR1XS
SW872 cell NV\2SJgzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M17ncGlvcGmkaYTpc44hd2ZiaIXtZY4hW1d6N{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg3PDV6IN88US=> MUDTRW5ITVJ?
TE-12 cell M4TEUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1\zUWlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg5QDNzIN88US=> NXe3dpZiW0GQR1XS
human HOP-62 cell M1;oZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXzJcohq[mm2aX;uJI9nKGi3bXHuJGhQWC14MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPVE2QTlizszN MYDTRW5ITVJ?
human NOS-1 cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYTLd|JSUW6qaXLpeIlwdiCxZjDoeY1idiCQT2OtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTVyNEWg{txO MVvTRW5ITVJ?
human BL-41 cell Mlm1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWPJcohq[mm2aX;uJI9nKGi3bXHuJGJNNTRzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wNFAyOyEQvF2= MmD4V2FPT0WU
human TGBC24TKB cell MmjvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlL0TY5pcWKrdHnvckBw\iCqdX3hckBVT0KFMkTUT2Ih[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB|OEOxJO69VQ>? M1jtUnNCVkeHUh?=
human KGN cell NG\0To1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWLZ[pRNUW6qaXLpeIlwdiCxZjDoeY1idiCNR16gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA2OjFizszN NVjHW2tPW0GQR1XS
human TK10 cell M4e2RWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGnIc4tKdmirYnn0bY9vKG:oIHj1cYFvKFSNMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA5PDF6IN88US=> NF\QZYJUSU6JRWK=
human GB-1 cell NF\GRlJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1TINWlvcGmkaYTpc44hd2ZiaIXtZY4hT0JvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVYxPjRizszN MYfTRW5ITVJ?
human GCIY cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoXjTY5pcWKrdHnvckBw\iCqdX3hckBIS0m\IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6yN|AyKM7:TR?= MlzvV2FPT0WU
human LXF-289 cell NVXtO2I6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MknLTY5pcWKrdHnvckBw\iCqdX3hckBNYEZvMki5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zPzJ3NjFOwG0> MkK4V2FPT0WU
RL95-2 cell NWrxWYU4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlLWTY5pcWKrdHnvckBw\iCqdX3hckBTVDl3LUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlMzPDN4IN88US=> NInDUphUSU6JRWK=
human SW962 cell NF3h[WhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlXSTY5pcWKrdHnvckBw\iCqdX3hckBUXzl4MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|M4PDJizszN MYXTRW5ITVJ?
human HT-144 cell MkfuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXP3ToRSUW6qaXLpeIlwdiCxZjDoeY1idiCKVD2xOFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjR2NUG3JO6ddQ>? MX7TRW5ITVJ?
human IST-SL2 cell M2mwXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWTJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2VTEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ4PDJzIN88US=> MWnTRW5ITVJ?
human NB6 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3HIV2lvcGmkaYTpc44hd2ZiaIXtZY4hVkJ4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT62PVY6QCEQvF2= NGi3e3VUSU6JRWK=
human SF126 cell MlvpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX\HNIFqUW6qaXLpeIlwdiCxZjDoeY1idiCVRkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPzNzN{ig{txO MnrVV2FPT0WU
human BOKU cell NYfYTXRbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnvwTY5pcWKrdHnvckBw\iCqdX3hckBDV0uXIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT64NFUzPyEQvF2= MnvRV2FPT0WU
human BB30-HNC cell NU\6OlN4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUjj[plsUW6qaXLpeIlwdiCxZjDoeY1idiCEQkOwMWhPSyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwOEW0O|Ih|ryP MoLvV2FPT0WU
human KLE cell NGDvdFZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnXqTY5pcWKrdHnvckBw\iCqdX3hckBMVEViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLki2NlMzKM7:TR?= M2LKd3NCVkeHUh?=
human MLMA cell M{Tl[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnPVTY5pcWKrdHnvckBw\iCqdX3hckBOVE2DIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT65NlMyKM7:TR?= NWOyO3IxW0GQR1XS
human KINGS-1 cell M4nJZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX\Jcohq[mm2aX;uJI9nKGi3bXHuJGtKVkeVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlk3QDl5IN88US=> MXrTRW5ITVJ?
human ES6 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlLXTY5pcWKrdHnvckBw\iCqdX3hckBGWzZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkC1OFAyKM7:TR?= M4DYNXNCVkeHUh?=
human SH-4 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXTJcohq[mm2aX;uJI9nKGi3bXHuJHNJNTRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGyNFU2KM7:TR?= MmfIV2FPT0WU
human D-263MG cell NXTnUVlVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1LoW2lvcGmkaYTpc44hd2ZiaIXtZY4hTC1{NkPNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjh6NUOg{txO NFrNVIxUSU6JRWK=
human SF268 cell NXHLb|l5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlzvTY5pcWKrdHnvckBw\iCqdX3hckBUTjJ4ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOFg3QDJizszN NGrwUIxUSU6JRWK=
human NB17 cell MonjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXLCc2NRUW6qaXLpeIlwdiCxZjDoeY1idiCQQkG3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk43Ojh5NTFOwG0> Mm\nV2FPT0WU
human DMS-114 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYX2[pB1UW6qaXLpeIlwdiCxZjDoeY1idiCGTWOtNVE1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi55OUCyNkDPxE1? MlfBV2FPT0WU
MC116 cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUfJcohq[mm2aX;uJI9nKGi3bXHuJG1EOTF4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj64OVcxPCEQvF2= MlvtV2FPT0WU
human NCI-H747 cell M4\xcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1:1WmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi3OFch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02Njd2MUW5JO69VQ>? M{X0cHNCVkeHUh?=
human A388 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml;UTY5pcWKrdHnvckBw\iCqdX3hckBCOzh6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUSuOlc2QCEQvF2= MlTKV2FPT0WU

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 12 mg/mL warmed (21.1 mM)
Ethanol 6 mg/mL warmed (10.55 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
1mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 568.67
Formula

C32H36N6O4

CAS No. 837422-57-8
Storage powder
in solvent
Synonyms KIN001-112, KIN112
Smiles COC1=CC=C(N(C(=O)OC2=C(C)C=CC=C2C)C3=CC=NC(=N3)NC4=CC=C(C=C4)N5CCN(C)CC5)C(=C1)OC

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Src Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID