WH-4-023

For research use only.

Catalog No.S7565 Synonyms: KIN001-112, KIN112

7 publications

WH-4-023 Chemical Structure

Molecular Weight(MW): 568.67

WH-4-023 is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.

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Selleck's WH-4-023 has been cited by 7 publications

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  • (G-I) WB analysis of total LCK, LCK Y505, and Src Y416 expression in ALL-SIL, CCRF-CEM, and TALL-1. Cells were treated with DMSO only (Ctrl), dasatinib, bosutinib, nintedanib, or WH-4-023 overnight at the compound concentrations corresponding to the GI50 at 48 hr. Bos, bosutinib; Das, dasatinib; Nint, nintedanib; WH, WH-4-023.

    Blood, 2017, 130(25):2750-2761. WH-4-023 purchased from Selleck.

Purity & Quality Control

Choose Selective Src Inhibitors

Biological Activity

Description WH-4-023 is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.
Targets
Lck [1]
(Cell-free assay)
Src [1]
(Cell-free assay)
2 nM 6 nM
In vitro

WH-4-023 shows little activity on p38 and KDR. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human EM-2 cell NHHCfINIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkDiTY5pcWKrdHnvckBw\iCqdX3hckBGVS1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz65NYUuODhizszN Mlm5V2FPT0WU
human LAMA-84 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn24TY5pcWKrdHnvckBw\iCqdX3hckBNSU2DLUi0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{44QGVvME[g{txO NY\TOXd2W0GQR1XS
human EoL-1-cell cell NUHHfYw5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2KyWWlvcGmkaYTpc44hd2ZiaIXtZY4hTW:OLUGtZ4VtdCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTlwNUHlMVA3KM7:TR?= MkPpV2FPT0WU
human MEG-01 cell NF7te5dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3PNRmlvcGmkaYTpc44hd2ZiaIXtZY4hVUWJLUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43O2VvMEWg{txO MVLTRW5ITVJ?
human CTV-1 cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYLJRVlyUW6qaXLpeIlwdiCxZjDoeY1idiCFVG[tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvOTinLUC1JO69VQ>? MUfTRW5ITVJ?
human BL-70 cell NVPQRW9ET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NET6N5ZKdmirYnn0bY9vKG:oIHj1cYFvKEKOLUewJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE44OmVvMEWg{txO M3G1TnNCVkeHUh?=
human K-562 cell NEHuVnNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1:4O2lvcGmkaYTpc44hd2ZiaIXtZY4hUy13NkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlAxODF4MjFOwG0> NVG1XXBQW0GQR1XS
human BV-173 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mkj3TY5pcWKrdHnvckBw\iCqdX3hckBDXi1zN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlAxODVzNDFOwG0> NFG1dZNUSU6JRWK=
human DOHH-2 cell NYLqXVVRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFfiU|FKdmirYnn0bY9vKG:oIHj1cYFvKESRSFitNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODByNUm3JO69VQ>? MVjTRW5ITVJ?
human A704 cell NX75eXpQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYrJcohq[mm2aX;uJI9nKGi3bXHuJGE4ODRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkCwNVI4KM7:TR?= NUPYdllEW0GQR1XS
human NCI-SNU-16 cell MnjuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXXJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2VTmWtNVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjBzNUeyJO69VQ>? M4XuXnNCVkeHUh?=
human LC-2-ad cell M4nMdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml7uTY5pcWKrdHnvckBw\iCqdX3hckBNSy1{LXHkJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xOjB|MzFOwG0> NIDaNHNUSU6JRWK=
human LB2518-MEL cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1rUfWlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ{NUG4MW1GVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMES2Olch|ryP MmDiV2FPT0WU
human D-336MG cell M{nxdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mm\STY5pcWKrdHnvckBw\iCqdX3hckBFNTN|Nl3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xPDZ6MTFOwG0> NXPxcHU{W0GQR1XS
human LB996-RCC cell NH7JNGtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Moe1TY5pcWKrdHnvckBw\iCqdX3hckBNSjl7Nj3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB3Nk[4JO69VQ>? NUn5cVc2W0GQR1XS
human Becker cell MnvqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkS5TY5pcWKrdHnvckBw\iCqdX3hckBD\WOtZYKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlA3OzhzIN88US=> MkPQV2FPT0WU
human LB1047-RCC cell NEDHTlZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXPJcohq[mm2aX;uJI9nKGi3bXHuJGxDOTB2Nz3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB5NUmyJO69VQ>? NYXMOYxbW0GQR1XS
human KS-1 cell NHjH[2FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX7u[2FNUW6qaXLpeIlwdiCxZjDoeY1idiCNUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xPzd3ODFOwG0> M2fWXXNCVkeHUh?=
human MPP-89 cell NVj5[ZNkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoTWTY5pcWKrdHnvckBw\iCqdX3hckBOWFBvOEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlA5OjJ7IN88US=> NFzjXGRUSU6JRWK=
human RXF393 cell MnPJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX7Jcohq[mm2aX;uJI9nKGi3bXHuJHJZTjN7MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNVA3OzNizszN NWTTUpMyW0GQR1XS
LB831-BLC cell Mn7OS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4LBOmlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ6M{GtRmxEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5zMkexOUDPxE1? NIjHfJpUSU6JRWK=
HUTU-80 cell NFrkNGZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFHaVY5KdmirYnn0bY9vKG:oIHj1cYFvKEiXVGWtPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjF5NUK5JO69VQ>? MVXTRW5ITVJ?
A498 cell NYfWcW9uT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWLJcohq[mm2aX;uJI9nKGi3bXHuJGE1QThiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkG4PVQ2KM7:TR?= NUXqfFhFW0GQR1XS
MZ1-PC cell MknzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2fTcGlvcGmkaYTpc44hd2ZiaIXtZY4hVVpzLWDDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4zOjdzNjFOwG0> MWLTRW5ITVJ?
TE-8 cell M3PENWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml2zTY5pcWKrdHnvckBw\iCqdX3hckBVTS16IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yN|kzPCEQvF2= NETMeXVUSU6JRWK=
MFH-ino cell  M3rMbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmH4TY5pcWKrdHnvckBw\iCqdX3hckBOTkhvaX7vJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4zOzl{NTFOwG0> M4nTfXNCVkeHUh?=
TE-15 cell NXLUe3Q6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUS3blh6UW6qaXLpeIlwdiCxZjDoeY1idiCWRT2xOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOjR{N{[g{txO MVLTRW5ITVJ?
NTERA-S-cl-D1 cell NWHNbGZHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWr6[JR7UW6qaXLpeIlwdiCxZjDoeY1idiCQVFXSRU1UNWOuLVSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4zQDh3NTFOwG0> MmLhV2FPT0WU
COLO-829 cell NHXzW|hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mnr1TY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLUiyPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOzF{MUKg{txO M4\MXXNCVkeHUh?=
SW684 cell NEm0[XVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIm2fIZKdmirYnn0bY9vKG:oIHj1cYFvKFOZNki0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{OjV6ODFOwG0> NF;UbFhUSU6JRWK=
OS-RC-2 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVrLeXo2UW6qaXLpeIlwdiCxZjDoeY1idiCRUz3SR{0zKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5|NUCxNUDPxE1? MUHTRW5ITVJ?
IST-MES1 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV;Jcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2PRWOxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{PTd{MzFOwG0> NFrqcIJUSU6JRWK=
SNB75 cell NVfIN5JXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFfPU4NKdmirYnn0bY9vKG:oIHj1cYFvKFOQQke1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{PTd5NDFOwG0> NXixSFBLW0GQR1XS
SW954 cell NF35[FZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEfKTmRKdmirYnn0bY9vKG:oIHj1cYFvKFOZOUW0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{PzF4MzFOwG0> NFLVXYZUSU6JRWK=
RCC10RGB cell M3XQNmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUXJcohq[mm2aX;uJI9nKGi3bXHuJHJESzFyUlfCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE41OjZ|MTFOwG0> NXuzSGd2W0GQR1XS
VA-ES-BJ cell NUDsSJJ5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIe1NHNKdmirYnn0bY9vKG:oIHj1cYFvKF[DLVXTMWJLKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC52NkK2JO69VQ>? MkLZV2FPT0WU
NCI-H1648 cell MlO3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2LQcWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlQ5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC53MUW4NkDPxE1? MorGV2FPT0WU
PF-382 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVXJcohq[mm2aX;uJI9nKGi3bXHuJHBHNTN6MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|A4PjNizszN MkLPV2FPT0WU
human Daudi cell NF3XbYxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUHJcohq[mm2aX;uJI9nKGi3bXHuJGRifWSrIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD63NVQyOSEQvF2= M2WxTHNCVkeHUh?=
SW982 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXLJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTh{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64OVgyQSEQvF2= MkDBV2FPT0WU
SW872 cell NI\uR21Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJHNYQDd{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64OlQ2QCEQvF2= NWPyXW9NW0GQR1XS
TE-12 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NW[2cWpNUW6qaXLpeIlwdiCxZjDoeY1idiCWRT2xNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQDh6M{Gg{txO NXLLZZZjW0GQR1XS
human HOP-62 cell M1LnRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVrJcohq[mm2aX;uJI9nKGi3bXHuJGhQWC14MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPVE2QTlizszN NYTsfZZNW0GQR1XS
human NOS-1 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlfzTY5pcWKrdHnvckBw\iCqdX3hckBPV1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPVUxPDVizszN MVPTRW5ITVJ?
human BL-41 cell Mon2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUPz[mhVUW6qaXLpeIlwdiCxZjDoeY1idiCETD20NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODByMUOg{txO MXrTRW5ITVJ?
human TGBC24TKB cell NFvkdIpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2PqRmlvcGmkaYTpc44hd2ZiaIXtZY4hXEeEQ{K0WGtDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5yM{izNUDPxE1? NVXVZ21DW0GQR1XS
human KGN cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1LtfWlvcGmkaYTpc44hd2ZiaIXtZY4hU0eQIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wOVIyKM7:TR?= NFm0S49USU6JRWK=
human TK10 cell NWr6XY9oT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHT5cJpKdmirYnn0bY9vKG:oIHj1cYFvKFSNMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA5PDF6IN88US=> MnKyV2FPT0WU
human GB-1 cell M2TNOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXjFb5JSUW6qaXLpeIlwdiCxZjDoeY1idiCJQj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPjB4NDFOwG0> M2m1T3NCVkeHUh?=
human GCIY cell NVHOcGJ1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUHJcohq[mm2aX;uJI9nKGi3bXHuJGdEUVliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkKzNFEh|ryP NWmzUnN{W0GQR1XS
human LXF-289 cell MmTBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUeyT5Z3UW6qaXLpeIlwdiCxZjDoeY1idiCOWF[tNlg6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5{N{K1OkDPxE1? Mn:4V2FPT0WU
RL95-2 cell NFfoUmFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX\wWYtmUW6qaXLpeIlwdiCxZjDoeY1idiCUTEm1MVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjN{NEO2JO69VQ>? NULOWFFiW0GQR1XS
human SW962 cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4fNXmlvcGmkaYTpc44hd2ZiaIXtZY4hW1d7NkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlM{PzR{IN88US=> M{jFSXNCVkeHUh?=
human HT-144 cell MorBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2jkbmlvcGmkaYTpc44hd2ZiaIXtZY4hUFRvMUS0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41PDVzNzFOoI0> NXfTT5dRW0GQR1XS
human IST-SL2 cell Mnv2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml71TY5pcWKrdHnvckBw\iCqdX3hckBKW1RvU1yyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41PzR{MTFOwG0> M1LVNnNCVkeHUh?=
human NB6 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFnMWZJKdmirYnn0bY9vKG:oIHj1cYFvKE6ENjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlk3QThizszN NYXBcnFTW0GQR1XS
human SF126 cell NFTTVlRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkjlTY5pcWKrdHnvckBw\iCqdX3hckBUTjF{NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|MyPzhizszN NXf1O49QW0GQR1XS
human BOKU cell MoTQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXTjeZQ4UW6qaXLpeIlwdiCxZjDoeY1idiCET1vVJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45ODV{NzFOwG0> M{LGeXNCVkeHUh?=
human BB30-HNC cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4ryUGlvcGmkaYTpc44hd2ZiaIXtZY4hSkJ|MD3IUmMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjh3NEeyJO69VQ>? M3zTWHNCVkeHUh?=
human KLE cell NF3mUFJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUPJcohq[mm2aX;uJI9nKGi3bXHuJGtNTSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwOE[yN|Ih|ryP NGDiWnlUSU6JRWK=
human MLMA cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3fYNGlvcGmkaYTpc44hd2ZiaIXtZY4hVUyPQTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPVI{OSEQvF2= M37qV3NCVkeHUh?=
human KINGS-1 cell Mn3aS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGftXIVKdmirYnn0bY9vKG:oIHj1cYFvKEuLTlfTMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl4OEm3JO69VQ>? NV;2PFVGW0GQR1XS
human ES6 cell MmLwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{LZTWlvcGmkaYTpc44hd2ZiaIXtZY4hTVN4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6wOVQxOSEQvF2= NIixfJlUSU6JRWK=
human SH-4 cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4PJd2lvcGmkaYTpc44hd2ZiaIXtZY4hW0hvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVIxPTVizszN MXfTRW5ITVJ?
human D-263MG cell MmewS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHz3VYhKdmirYnn0bY9vKG:oIHj1cYFvKERvMk[zUWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ6OEWzJO69VQ>? M4C2UXNCVkeHUh?=
human SF268 cell M3;odWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3fIPGlvcGmkaYTpc44hd2ZiaIXtZY4hW0Z{NkigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlQ5Pjh{IN88US=> M4DuS3NCVkeHUh?=
human NB17 cell MkXKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEfRRZVKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlYzQDd3IN88US=> M{T1WHNCVkeHUh?=
human DMS-114 cell M{KxdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M36wcWlvcGmkaYTpc44hd2ZiaIXtZY4hTE2VLUGxOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzlyMkKg{txO M17TTXNCVkeHUh?=
MC116 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH:0V|VKdmirYnn0bY9vKG:oIHj1cYFvKE2FMUG2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk45PTdyNDFOwG0> M{nBc3NCVkeHUh?=
human NCI-H747 cell NWfjVXhxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MorZTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEe0O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzRzNUmg{txO MX;TRW5ITVJ?
human A388 cell MmjpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUjJcohq[mm2aX;uJI9nKGi3bXHuJGE{QDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zND62O|U5KM7:TR?= Ml;KV2FPT0WU

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 12 mg/mL warmed (21.1 mM)
Water Insoluble
Ethanol '6 mg/mL warmed
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
1mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 568.67
Formula

C32H36N6O4

CAS No. 837422-57-8
Storage powder
in solvent
Synonyms KIN001-112, KIN112
Smiles COC1=CC=C(N(C(=O)OC2=C(C)C=CC=C2C)C3=CC=NC(=N3)NC4=CC=C(C=C4)N5CCN(C)CC5)C(=C1)OC

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID