WH-4-023

Catalog No.S7565 Synonyms: KIN001-112, KIN112

WH-4-023 Chemical Structure

Molecular Weight(MW): 568.67

WH-4-023 is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.

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Cited by 3 Publications

1 Customer Review

  • (G-I) WB analysis of total LCK, LCK Y505, and Src Y416 expression in ALL-SIL, CCRF-CEM, and TALL-1. Cells were treated with DMSO only (Ctrl), dasatinib, bosutinib, nintedanib, or WH-4-023 overnight at the compound concentrations corresponding to the GI50 at 48 hr. Bos, bosutinib; Das, dasatinib; Nint, nintedanib; WH, WH-4-023.

    Blood, 2017, 130(25):2750-2761. WH-4-023 purchased from Selleck.

Purity & Quality Control

Choose Selective Src Inhibitors

Biological Activity

Description WH-4-023 is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.
Targets
Lck [1]
(Cell-free assay)
Src [1]
(Cell-free assay)
2 nM 6 nM
In vitro

WH-4-023 shows little activity on p38 and KDR. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human EM-2 cell NI[3eFhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGjYNHRKdmirYnn0bY9vKG:oIHj1cYFvKEWPLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlky\S1yODFOwG0> MUTTRW5ITVJ?
human LAMA-84 cell NHP5doRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUXXWFJ{UW6qaXLpeIlwdiCxZjDoeY1idiCOQV3BMVg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oy55OHWtNFYh|ryP M3LNdXNCVkeHUh?=
human EoL-1-cell cell M1XtfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MofNTY5pcWKrdHnvckBw\iCqdX3hckBGd0xvMT3j[YxtKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QS53MXWtNFYh|ryP NVjnVmlmW0GQR1XS
human MEG-01 cell NX\RZ4tuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlO3TY5pcWKrdHnvckBw\iCqdX3hckBOTUdvMEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlY{\S1yNTFOwG0> MX7TRW5ITVJ?
human CTV-1 cell M12zb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHHu[W5KdmirYnn0bY9vKG:oIHj1cYFvKEOWVj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4yQGVvMEWg{txO NHvv[IFUSU6JRWK=
human BL-70 cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2PTVmlvcGmkaYTpc44hd2ZiaIXtZY4hSkxvN{CgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20Mlcz\S1yNTFOwG0> MnnTV2FPT0WU
human K-562 cell NE\Qd2hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkHqTY5pcWKrdHnvckBw\iCqdX3hckBMNTV4MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNFAxOTZ{IN88US=> MkfEV2FPT0WU
human BV-173 cell MknyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVrmTVFJUW6qaXLpeIlwdiCxZjDoeY1idiCEVj2xO|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjByMEWxOEDPxE1? NUGweGxDW0GQR1XS
human DOHH-2 cell NGnmN2lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmrTTY5pcWKrdHnvckBw\iCqdX3hckBFV0iKLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlAxODV7NzFOwG0> Mle4V2FPT0WU
human A704 cell MmixS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1nDOmlvcGmkaYTpc44hd2ZiaIXtZY4hSTdyNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNFAyOjdizszN MmSwV2FPT0WU
human NCI-SNU-16 cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXfJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2VTmWtNVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjBzNUeyJO69VQ>? MXvTRW5ITVJ?
human LC-2-ad cell NFXMPG1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3[zbGlvcGmkaYTpc44hd2ZiaIXtZY4hVENvMj3h[EBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODJyM{Og{txO M4PhfXNCVkeHUh?=
human LB2518-MEL cell M1ryZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWXhdGd7UW6qaXLpeIlwdiCxZjDoeY1idiCOQkK1NVguVUWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wOFY3PyEQvF2= MVfTRW5ITVJ?
human D-336MG cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXrK[o5nUW6qaXLpeIlwdiCxZjDoeY1idiCGLUOzOm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yNE[4NUDPxE1? NVTmdmJpW0GQR1XS
human LB996-RCC cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3HWNmlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ7OU[tVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yNU[2PEDPxE1? NV3xOmx[W0GQR1XS
human Becker cell NEK3eFBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHz0TW5KdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODZ|OEGg{txO MkHzV2FPT0WU
human LB1047-RCC cell NHXVU2JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MojYTY5pcWKrdHnvckBw\iCqdX3hckBNSjFyNEetVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yN{W5NkDPxE1? MWrTRW5ITVJ?
human KS-1 cell M{\MN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mk\hTY5pcWKrdHnvckBw\iCqdX3hckBMWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wO|c2QCEQvF2= NVzIbm1kW0GQR1XS
human MPP-89 cell MkDLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGLTZlJKdmirYnn0bY9vKG:oIHj1cYFvKE2SUD24PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODh{Mkmg{txO Moj0V2FPT0WU
human RXF393 cell M1vIcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEPoXlFKdmirYnn0bY9vKG:oIHj1cYFvKFK[RkO5N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTB4M{Og{txO NVvtNZlFW0GQR1XS
LB831-BLC cell NWDpXI9NT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUDJcohq[mm2aX;uJI9nKGi3bXHuJGxDQDNzLVLMR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTJ5MUWg{txO MmnWV2FPT0WU
HUTU-80 cell M4Xpe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnGwTY5pcWKrdHnvckBw\iCqdX3hckBJXVSXLUiwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yPzV{OTFOwG0> Mn\2V2FPT0WU
A498 cell M33JO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2\1UWlvcGmkaYTpc44hd2ZiaIXtZY4hSTR7ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNVg6PDVizszN NWi4T|BSW0GQR1XS
MZ1-PC cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUjR[HhHUW6qaXLpeIlwdiCxZjDoeY1idiCPWkGtVGMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjJ{N{G2JO69VQ>? MXHTRW5ITVJ?
TE-8 cell NIK5SItIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEjUS|lKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlI{QTJ2IN88US=> MVfTRW5ITVJ?
MFH-ino cell  MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYXJcohq[mm2aX;uJI9nKGi3bXHuJG1HUC2rbn:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlI{QTJ3IN88US=> M2XEPHNCVkeHUh?=
TE-15 cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml32TY5pcWKrdHnvckBw\iCqdX3hckBVTS1zNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNlQzPzZizszN MnLqV2FPT0WU
NTERA-S-cl-D1 cell MkGzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXPxcopEUW6qaXLpeIlwdiCxZjDoeY1idiCQVFXSRU1UNWOuLVSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4zQDh3NTFOwG0> MorPV2FPT0WU
COLO-829 cell NYe1WWVQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3;2XGlvcGmkaYTpc44hd2ZiaIXtZY4hS0:OTz24Nlkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjNzMkGyJO69VQ>? Mlj2V2FPT0WU
SW684 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWPJcohq[mm2aX;uJI9nKGi3bXHuJHNYPjh2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6zNlU5QCEQvF2= NUTObJc6W0GQR1XS
OS-RC-2 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mm\zTY5pcWKrdHnvckBw\iCqdX3hckBQWy2UQz2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{PTBzMTFOwG0> Ml:wV2FPT0WU
IST-MES1 cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVnJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2PRWOxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{PTd{MzFOwG0> NV:1RnE2W0GQR1XS
SNB75 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{e5WGlvcGmkaYTpc44hd2ZiaIXtZY4hW06EN{WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlM2Pzd2IN88US=> MULTRW5ITVJ?
SW954 cell M3\weGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHqyNmpKdmirYnn0bY9vKG:oIHj1cYFvKFOZOUW0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{PzF4MzFOwG0> MkPRV2FPT0WU
RCC10RGB cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2LncGlvcGmkaYTpc44hd2ZiaIXtZY4hWkOFMUDSS2Ih[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjR{NkOxJO69VQ>? MV\TRW5ITVJ?
VA-ES-BJ cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWD1Tpd[UW6qaXLpeIlwdiCxZjDoeY1idiCYQT3FV{1DUiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwNE[yOkDPxE1? NWG4R3JpW0GQR1XS
NCI-H1648 cell Mn;lS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX34VoRPUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE3PDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkWxOVgzKM7:TR?= NH7SRVRUSU6JRWK=
PF-382 cell Ml\tS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEfYcFhKdmirYnn0bY9vKG:oIHj1cYFvKFCILUO4NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzB5NkOg{txO MmL0V2FPT0WU
human Daudi cell MlPzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mne1TY5pcWKrdHnvckBw\iCqdX3hckBF[XWmaTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|E1OTFizszN MkHsV2FPT0WU
SW982 cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn3lTY5pcWKrdHnvckBw\iCqdX3hckBUXzl6MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFU5OTlizszN NVy3NlNjW0GQR1XS
SW872 cell M1zaPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1y5ZmlvcGmkaYTpc44hd2ZiaIXtZY4hW1d6N{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg3PDV6IN88US=> MXfTRW5ITVJ?
TE-12 cell NGrtZVNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnroTY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFg5OzFizszN M2DPPHNCVkeHUh?=
human HOP-62 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHfGNmpKdmirYnn0bY9vKG:oIHj1cYFvKEiRUD22NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTF3OUmg{txO M{j4bHNCVkeHUh?=
human NOS-1 cell NGDSd2JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3ruO2lvcGmkaYTpc44hd2ZiaIXtZY4hVk:VLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlk2ODR3IN88US=> M3qyfnNCVkeHUh?=
human BL-41 cell NGrMV2NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn3sTY5pcWKrdHnvckBw\iCqdX3hckBDVC12MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFAxOTNizszN MYrTRW5ITVJ?
human TGBC24TKB cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGS0PIhKdmirYnn0bY9vKG:oIHj1cYFvKFSJQlOyOHRMSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMEO4N|Eh|ryP M1;ORnNCVkeHUh?=
human KGN cell M1TaNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF2zc21KdmirYnn0bY9vKG:oIHj1cYFvKEuJTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFUzOSEQvF2= MofsV2FPT0WU
human TK10 cell M1XkV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mnn6TY5pcWKrdHnvckBw\iCqdX3hckBVUzFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wPFQyQCEQvF2= MYHTRW5ITVJ?
human GB-1 cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUK3UlBYUW6qaXLpeIlwdiCxZjDoeY1idiCJQj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPjB4NDFOwG0> Mlj6V2FPT0WU
human GCIY cell M3XjTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWjQTJpDUW6qaXLpeIlwdiCxZjDoeY1idiCJQ1nZJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zOzBzIN88US=> MUjTRW5ITVJ?
human LXF-289 cell NE\zSnlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NU\W[IZJUW6qaXLpeIlwdiCxZjDoeY1idiCOWF[tNlg6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5{N{K1OkDPxE1? M3TEfnNCVkeHUh?=
RL95-2 cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1vjfmlvcGmkaYTpc44hd2ZiaIXtZY4hWkx7NT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{OjR|NjFOwG0> MV\TRW5ITVJ?
human SW962 cell NVzNeo5MT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmjETY5pcWKrdHnvckBw\iCqdX3hckBUXzl4MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|M4PDJizszN NF[4eW9USU6JRWK=
human HT-144 cell NHLUPI5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGHncIZKdmirYnn0bY9vKG:oIHj1cYFvKEiWLUG0OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDR3MUeg{rxu NIfRO4xUSU6JRWK=
human IST-SL2 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVrlZo9YUW6qaXLpeIlwdiCxZjDoeY1idiCLU2StV2wzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS52N{SyNUDPxE1? NELkc|NUSU6JRWK=
human NB6 cell M2TiR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVLkT5BFUW6qaXLpeIlwdiCxZjDoeY1idiCQQk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlY6Pjl6IN88US=> MWjTRW5ITVJ?
human SF126 cell M2\LZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXnJcohq[mm2aX;uJI9nKGi3bXHuJHNHOTJ4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63N|E4QCEQvF2= NXTpU5Z2W0GQR1XS
human BOKU cell M1ntN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIjENItKdmirYnn0bY9vKG:oIHj1cYFvKEKRS2WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlgxPTJ5IN88US=> MWHTRW5ITVJ?
human BB30-HNC cell NWC0coxzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGfTZlRKdmirYnn0bY9vKG:oIHj1cYFvKEKEM{CtTG5EKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS56NUS3NkDPxE1? NYntbYtTW0GQR1XS
human KLE cell NF7qTXNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlqyTY5pcWKrdHnvckBw\iCqdX3hckBMVEViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLki2NlMzKM7:TR?= MWjTRW5ITVJ?
human MLMA cell NILncplIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV\uWmVHUW6qaXLpeIlwdiCxZjDoeY1idiCPTF3BJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46OjNzIN88US=> NHG3fWtUSU6JRWK=
human KINGS-1 cell M3jPeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIfrdFJKdmirYnn0bY9vKG:oIHj1cYFvKEuLTlfTMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl4OEm3JO69VQ>? M{nScnNCVkeHUh?=
human ES6 cell MlHES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVzJcohq[mm2aX;uJI9nKGi3bXHuJGVUPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMEW0NFEh|ryP NYDtNoNOW0GQR1XS
human SH-4 cell NXvTcXlET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkTNTY5pcWKrdHnvckBw\iCqdX3hckBUUC12IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6xNlA2PSEQvF2= Mln0V2FPT0WU
human D-263MG cell NYjiVWJzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3ztcmlvcGmkaYTpc44hd2ZiaIXtZY4hTC1{NkPNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjh6NUOg{txO M4T6cHNCVkeHUh?=
human SF268 cell NYXUdoNyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1yxdWlvcGmkaYTpc44hd2ZiaIXtZY4hW0Z{NkigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlQ5Pjh{IN88US=> NGj6c|hUSU6JRWK=
human NB17 cell NUHu[ZQzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVTJcohq[mm2aX;uJI9nKGi3bXHuJG5DOTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[yPFc2KM7:TR?= M1jCXnNCVkeHUh?=
human DMS-114 cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVHJcohq[mm2aX;uJI9nKGi3bXHuJGROWy1zMUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlc6ODJ{IN88US=> NFTQTHJUSU6JRWK=
MC116 cell NIPlR2ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mmj6TY5pcWKrdHnvckBw\iCqdX3hckBOSzFzNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuPFU4ODRizszN NH\leYVUSU6JRWK=
human NCI-H747 cell Ml;WS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2HFd2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi3OFch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02Njd2MUW5JO69VQ>? M2jSVXNCVkeHUh?=
human A388 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWrrd5Y3UW6qaXLpeIlwdiCxZjDoeY1idiCDM{i4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVQvPjd3ODFOwG0> NVf6eZgxW0GQR1XS

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 12 mg/mL warmed (21.1 mM)
Ethanol 6 mg/mL warmed (10.55 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
1mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 568.67
Formula

C32H36N6O4

CAS No. 837422-57-8
Storage powder
in solvent
Synonyms KIN001-112, KIN112

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Src Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID