WH-4-023

Catalog No.S7565 Synonyms: KIN001-112, KIN112

WH-4-023 Chemical Structure

Molecular Weight(MW): 568.67

WH-4-023 is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.

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Cited by 3 Publications

1 Customer Review

  • (G-I) WB analysis of total LCK, LCK Y505, and Src Y416 expression in ALL-SIL, CCRF-CEM, and TALL-1. Cells were treated with DMSO only (Ctrl), dasatinib, bosutinib, nintedanib, or WH-4-023 overnight at the compound concentrations corresponding to the GI50 at 48 hr. Bos, bosutinib; Das, dasatinib; Nint, nintedanib; WH, WH-4-023.

    Blood, 2017, 130(25):2750-2761. WH-4-023 purchased from Selleck.

Purity & Quality Control

Choose Selective Src Inhibitors

Biological Activity

Description WH-4-023 is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.
Targets
Lck [1]
(Cell-free assay)
Src [1]
(Cell-free assay)
2 nM 6 nM
In vitro

WH-4-023 shows little activity on p38 and KDR. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human EM-2 cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnLETY5pcWKrdHnvckBw\iCqdX3hckBGVS1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz65NYUuODhizszN MUjTRW5ITVJ?
human LAMA-84 cell NFjMTIRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mlr2TY5pcWKrdHnvckBw\iCqdX3hckBNSU2DLUi0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{44QGVvME[g{txO MlXrV2FPT0WU
human EoL-1-cell cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX7Jcohq[mm2aX;uJI9nKGi3bXHuJGVwVC1zLXPlcIwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06NjVzZT2wOkDPxE1? M{O0bHNCVkeHUh?=
human MEG-01 cell M4foRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2XibWlvcGmkaYTpc44hd2ZiaIXtZY4hVUWJLUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43O2VvMEWg{txO MlL2V2FPT0WU
human CTV-1 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnPrTY5pcWKrdHnvckBw\iCqdX3hckBEXFZvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNVhmNTB3IN88US=> MWXTRW5ITVJ?
human BL-70 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVXJcohq[mm2aX;uJI9nKGi3bXHuJGJNNTdyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND63NoUuODVizszN MVrTRW5ITVJ?
human K-562 cell NFfvNIxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGjvNXlKdmirYnn0bY9vKG:oIHj1cYFvKEtvNU[yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xODBzNkKg{txO MWnTRW5ITVJ?
human BV-173 cell M4LJVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYnJcohq[mm2aX;uJI9nKGi3bXHuJGJXNTF5MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNFAxPTF2IN88US=> NFG1SY9USU6JRWK=
human DOHH-2 cell Ml3mS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2XEeGlvcGmkaYTpc44hd2ZiaIXtZY4hTE:KSD2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xODB3OUeg{txO MX3TRW5ITVJ?
human A704 cell NIPQRlhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M332emlvcGmkaYTpc44hd2ZiaIXtZY4hSTdyNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNFAyOjdizszN MXPTRW5ITVJ?
human NCI-SNU-16 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXTmS3Z5UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtV25WNTF4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wNVU4OiEQvF2= MVjTRW5ITVJ?
human LC-2-ad cell M2HPfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUfrNXV1UW6qaXLpeIlwdiCxZjDoeY1idiCOQz2yMYFlKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yMkCzN{DPxE1? NHrxSG1USU6JRWK=
human LB2518-MEL cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXXJcohq[mm2aX;uJI9nKGi3bXHuJGxDOjVzOD3NSWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB2Nk[3JO69VQ>? MVzTRW5ITVJ?
human D-336MG cell NEjMPG9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXnuV4dWUW6qaXLpeIlwdiCxZjDoeY1idiCGLUOzOm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yNE[4NUDPxE1? MYTTRW5ITVJ?
human LB996-RCC cell M3juZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXjJcohq[mm2aX;uJI9nKGi3bXHuJGxDQTl4LWLDR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODV4Nkig{txO NYLWOJJwW0GQR1XS
human Becker cell NXvuTpZ7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIDWZ21KdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODZ|OEGg{txO Mo[wV2FPT0WU
human LB1047-RCC cell NVj1doNbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYrHfG1ZUW6qaXLpeIlwdiCxZjDoeY1idiCOQkGwOFcuWkOFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wO|U6OiEQvF2= NGTleFBUSU6JRWK=
human KS-1 cell NHP4[GRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUnYSlF7UW6qaXLpeIlwdiCxZjDoeY1idiCNUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xPzd3ODFOwG0> NXrWe|hEW0GQR1XS
human MPP-89 cell MnrMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkDaTY5pcWKrdHnvckBw\iCqdX3hckBOWFBvOEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlA5OjJ7IN88US=> MVzTRW5ITVJ?
human RXF393 cell NITHdFFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWfJcohq[mm2aX;uJI9nKGi3bXHuJHJZTjN7MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNVA3OzNizszN NF:wXpdUSU6JRWK=
LB831-BLC cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlfwTY5pcWKrdHnvckBw\iCqdX3hckBNSjh|MT3CUGMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjF{N{G1JO69VQ>? M{[yXXNCVkeHUh?=
HUTU-80 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVPzTFF6UW6qaXLpeIlwdiCxZjDoeY1idiCKVWTVMVgxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5zN{WyPUDPxE1? NUe5Z|ZsW0GQR1XS
A498 cell NXO3XZgxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYT0coJIUW6qaXLpeIlwdiCxZjDoeY1idiCDNEm4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yQDl2NTFOwG0> M1vx[3NCVkeHUh?=
MZ1-PC cell NFu5[3lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2[5TmlvcGmkaYTpc44hd2ZiaIXtZY4hVVpzLWDDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4zOjdzNjFOwG0> M365XXNCVkeHUh?=
TE-8 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWHJcohq[mm2aX;uJI9nKGi3bXHuJHRGNThiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkKzPVI1KM7:TR?= MnTkV2FPT0WU
MFH-ino cell  MoDTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYfJcohq[mm2aX;uJI9nKGi3bXHuJG1HUC2rbn:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlI{QTJ3IN88US=> MUjTRW5ITVJ?
TE-15 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFvoN2ZKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUG1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4zPDJ5NjFOwG0> NIHwOIZUSU6JRWK=
NTERA-S-cl-D1 cell MnnJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{i1TWlvcGmkaYTpc44hd2ZiaIXtZY4hVlSHUlGtV{1kdC2GMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNlg5PTVizszN MWnTRW5ITVJ?
COLO-829 cell NV20NFFmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3jnbWlvcGmkaYTpc44hd2ZiaIXtZY4hS0:OTz24Nlkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjNzMkGyJO69VQ>? M17RUXNCVkeHUh?=
SW684 cell M{LuTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3;VV2lvcGmkaYTpc44hd2ZiaIXtZY4hW1d4OESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlMzPTh6IN88US=> NGT0OGVUSU6JRWK=
OS-RC-2 cell MknNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWLJcohq[mm2aX;uJI9nKGi3bXHuJG9UNVKFLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlM2ODFzIN88US=> NIHqdnRUSU6JRWK=
IST-MES1 cell MoHtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGXp[WNKdmirYnn0bY9vKG:oIHj1cYFvKEmVVD3NSXMyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5|NUeyN{DPxE1? M{nhTXNCVkeHUh?=
SNB75 cell MmXkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MojWTY5pcWKrdHnvckBw\iCqdX3hckBUVkJ5NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuN|U4PzRizszN MXvTRW5ITVJ?
SW954 cell NUjmcG57T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYXrfoZtUW6qaXLpeIlwdiCxZjDoeY1idiCVV{m1OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOzdzNkOg{txO M1f3WnNCVkeHUh?=
RCC10RGB cell Mk\rS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVzxSYhVUW6qaXLpeIlwdiCxZjDoeY1idiCUQ1OxNHJISiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwNEK2N|Eh|ryP M4jVb3NCVkeHUh?=
VA-ES-BJ cell MlW1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYfmeZU6UW6qaXLpeIlwdiCxZjDoeY1idiCYQT3FV{1DUiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwNE[yOkDPxE1? MYnTRW5ITVJ?
NCI-H1648 cell NXPB[4hGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3PKT2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlQ5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC53MUW4NkDPxE1? MnSwV2FPT0WU
PF-382 cell MmfmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2fTSWlvcGmkaYTpc44hd2ZiaIXtZY4hWEZvM{iyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44ODd4MzFOwG0> NWnBUJk6W0GQR1XS
human Daudi cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1TRfGlvcGmkaYTpc44hd2ZiaIXtZY4hTGG3ZHmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlcyPDFzIN88US=> MXLTRW5ITVJ?
SW982 cell M4XNXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2eySWlvcGmkaYTpc44hd2ZiaIXtZY4hW1d7OEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg2QDF7IN88US=> Mn\KV2FPT0WU
SW872 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mlv1TY5pcWKrdHnvckBw\iCqdX3hckBUXzh5MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFY1PThizszN NYPIS4w1W0GQR1XS
TE-12 cell NXzyUnlIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2TZ[GlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg5QDNzIN88US=> NUL3V5hnW0GQR1XS
human HOP-62 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUnkXW9QUW6qaXLpeIlwdiCxZjDoeY1idiCKT2CtOlIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjlzNUm5JO69VQ>? MlXaV2FPT0WU
human NOS-1 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{XHZWlvcGmkaYTpc44hd2ZiaIXtZY4hVk:VLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlk2ODR3IN88US=> Ml7GV2FPT0WU
human BL-41 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3XEbmlvcGmkaYTpc44hd2ZiaIXtZY4hSkxvNEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlAxODF|IN88US=> M{K1b3NCVkeHUh?=
human TGBC24TKB cell NGSybHhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXj0UHZJUW6qaXLpeIlwdiCxZjDoeY1idiCWR1LDNlRVU0JiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkCzPFMyKM7:TR?= NVXsS3k4W0GQR1XS
human KGN cell NFPOSoNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4rtTWlvcGmkaYTpc44hd2ZiaIXtZY4hU0eQIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wOVIyKM7:TR?= NEfseolUSU6JRWK=
human TK10 cell M1;3VWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml7JTY5pcWKrdHnvckBw\iCqdX3hckBVUzFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wPFQyQCEQvF2= M2[4fnNCVkeHUh?=
human GB-1 cell M4fDVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4[5fmlvcGmkaYTpc44hd2ZiaIXtZY4hT0JvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVYxPjRizszN M4iySnNCVkeHUh?=
human GCIY cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXfJcohq[mm2aX;uJI9nKGi3bXHuJGdEUVliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkKzNFEh|ryP M4PLR3NCVkeHUh?=
human LXF-289 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mly3TY5pcWKrdHnvckBw\iCqdX3hckBNYEZvMki5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zPzJ3NjFOwG0> NYLZV4xSW0GQR1XS
RL95-2 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn:1TY5pcWKrdHnvckBw\iCqdX3hckBTVDl3LUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlMzPDN4IN88US=> MkTUV2FPT0WU
human SW962 cell NXTTWYR1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mkn3TY5pcWKrdHnvckBw\iCqdX3hckBUXzl4MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|M4PDJizszN NW[weGdRW0GQR1XS
human HT-144 cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NU\RN3JbUW6qaXLpeIlwdiCxZjDoeY1idiCKVD2xOFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjR2NUG3JO6ddQ>? MYrTRW5ITVJ?
human IST-SL2 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYDET3dGUW6qaXLpeIlwdiCxZjDoeY1idiCLU2StV2wzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS52N{SyNUDPxE1? MkfXV2FPT0WU
human NB6 cell NVy4Spd1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGCzRVNKdmirYnn0bY9vKG:oIHj1cYFvKE6ENjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlk3QThizszN MoHSV2FPT0WU
human SF126 cell M2HUPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYnJcohq[mm2aX;uJI9nKGi3bXHuJHNHOTJ4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63N|E4QCEQvF2= NY\zR5hmW0GQR1XS
human BOKU cell Mle1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlO4TY5pcWKrdHnvckBw\iCqdX3hckBDV0uXIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT64NFUzPyEQvF2= M{WyZ3NCVkeHUh?=
human BB30-HNC cell MmH3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF6xfGNKdmirYnn0bY9vKG:oIHj1cYFvKEKEM{CtTG5EKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS56NUS3NkDPxE1? Mkn5V2FPT0WU
human KLE cell NGT4eo9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkW5TY5pcWKrdHnvckBw\iCqdX3hckBMVEViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLki2NlMzKM7:TR?= NWjpbnZTW0GQR1XS
human MLMA cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIDhW2dKdmirYnn0bY9vKG:oIHj1cYFvKE2OTVGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlkzOzFizszN MXTTRW5ITVJ?
human KINGS-1 cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV7Jcohq[mm2aX;uJI9nKGi3bXHuJGtKVkeVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlk3QDl5IN88US=> NVnienFoW0GQR1XS
human ES6 cell MmnXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4POcGlvcGmkaYTpc44hd2ZiaIXtZY4hTVN4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6wOVQxOSEQvF2= MVPTRW5ITVJ?
human SH-4 cell MoP1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWjJcohq[mm2aX;uJI9nKGi3bXHuJHNJNTRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGyNFU2KM7:TR?= NIj6Ro5USU6JRWK=
human D-263MG cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MU\Jcohq[mm2aX;uJI9nKGi3bXHuJGQuOjZ|TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI5QDV|IN88US=> M2HvUHNCVkeHUh?=
human SF268 cell M4j1fmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEfkNoZKdmirYnn0bY9vKG:oIHj1cYFvKFOIMk[4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41QDZ6MjFOwG0> M2rJbHNCVkeHUh?=
human NB17 cell NEjKc|ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{fuNWlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzNzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOlI5PzVizszN MkTPV2FPT0WU
human DMS-114 cell NXHSWG1JT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmSzTY5pcWKrdHnvckBw\iCqdX3hckBFVVNvMUG0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44QTB{MjFOwG0> NYjwclFCW0GQR1XS
MC116 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEHMcmpKdmirYnn0bY9vKG:oIHj1cYFvKE2FMUG2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk45PTdyNDFOwG0> NEi3[nNUSU6JRWK=
human NCI-H747 cell NYH4NHN4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml;ETY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEe0O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzRzNUmg{txO MkK0V2FPT0WU
human A388 cell M2K0OGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVi0V4JDUW6qaXLpeIlwdiCxZjDoeY1idiCDM{i4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVQvPjd3ODFOwG0> M320TnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 12 mg/mL warmed (21.1 mM)
Ethanol 6 mg/mL warmed (10.55 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
1mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 568.67
Formula

C32H36N6O4

CAS No. 837422-57-8
Storage powder
in solvent
Synonyms KIN001-112, KIN112

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Src Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID