WY-14643 (Pirinixic Acid)

For research use only.

Catalog No.S8029 Synonyms: NSC 310038

7 publications

WY-14643 (Pirinixic Acid) Chemical Structure

Molecular Weight(MW): 323.8

WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with EC50 of 1.5 μM.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 190 In stock
USD 97 In stock
USD 310 In stock
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Selleck's WY-14643 (Pirinixic Acid) has been cited by 7 publications

1 Customer Review

  • (A) Acot1 mRNA following adenovirus treatments and 0.1% Wy-14643 supplementation (n=7-9). (B) H&E staining shows that Wy-14643 reduced and normalized lipid droplet accumulation in the Acot1 knockdown treatment group.

    Diabetes, 2017, 66(8):2112-2123. WY-14643 (Pirinixic Acid) purchased from Selleck.

Purity & Quality Control

Choose Selective PPAR Inhibitors

Biological Activity

Description WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with EC50 of 1.5 μM.
Targets
PPARα [1]
1.5 μM(EC50)
In vitro

WY 14643 (10 μM) almost completely inhibits interleukin-1-induced production of interleukin-6 and prostaglandin and expression of cyclooxygenase-2 in aortic smooth-muscle cells, through repression of NF-κB signaling. [2] WY14643 (250 μM) reduces VCAM-1 expression levels significantly, to 52 % of TNF-α-stimulated human endothelial cells. Pretreatment of endothelial cells with WY 14643 (10 μM) before TNF-α stimulation reduces U937 cell adhesion by 50%. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Hep G2 cells MlXCSpVv[3Srb36gZZN{[Xl? NY\3[JVHSWexbnnzeEBi[3Srdnn0fUBifCCvb4Xz[UBRWEGUYXzwbIEhdGmpYX7kJIJqdmSrbneg[I9u[WmwIHX4dJJme3OnZDDpckBpfW2jbjDI[ZAhTzJiY3XscJMh[29vdILhcpNn\WO2ZXSge4l1cCCJYXy0MWRDTCCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9NE4xPCEQvF2= MluyNVkxPTN5N{[=
MCF7 cells M1HvWmZ2dmO2aX;uJIF{e2G7 NGDjfFRC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBRSVKjbIDoZUBmgHC{ZYPz[YQhcW5iTVPGO{Bk\WyuczDjc{11emGwc3\lZ5Rm\CCFUGTJJGRTOS22eYDlJHJGKGGodHXyJFYhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjV2MjFOwG0> NXfwWoxwOjR7M{[yN|I>
U2OS cells MlyzSpVv[3Srb36gZZN{[Xl? M136[mFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gVHBCWmGucHjhJIlvKFV{T2OgZ4VtdHNiYomgeJJidnOjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwQVEzKM7:TR?= MmPRNVg{Ojl5NUG=
HEK293 cells MYLGeY5kfGmxbjDhd5NigQ>? M1fsWGFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gVHBCWmGucHjhJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZ491emGwc3\lZ5Rm\CC5aYToJHBRWkW6ND3UT{1tfWNiYYPz[ZN{\WRiYYOgZYN1cX[jdHnvckBw\iCudXPp[oVz[XOnIHHjeIl3cXS7IH3lZZN2emWmIHHmeIVzKDR6IHjyd{BjgSC2cnHud4FkfGm4YYTpc44h[XO|YYmsJGVEPTB;MkOuN|Mh|ryP NYPIcFg5OjN{NkW4OFQ>
COS7 cells NHrVR5FHfW6ldHnvckBie3OjeR?= MofmRYN1cX[jdHnvckBw\iCqdX3hckBRWEGUYXzwbIEhdGmpYX7kJIJqdmSrbneg[I9u[WmwIHX4dJJme3OnZDDpckBEV1N5IHPlcIx{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3ME2zOk4{KM7:TR?= MmrvNlUxOzd7MUS=
EAhy926 cells  MknBSpVv[3Srb36gZZN{[Xl? MmDsNVAhfU1? MnfWNVIhcA>? M4TrV2lvcGmkaYTpc44hd2ZidIXi[UBnd3KvYYTpc44hcW5iaIXtZY4hTUGqeUmyOkBk\WyuczDheEAyOCC3TTDwdoUucW6ldXLheIVlKG[xcjCxNkBpenNibXXhd5Vz\WRiYX\0[ZIhOjRiaILzJIJ6KHCqYYPlMYNwdnS{YYP0JI1q[3Kxc3PvdJk> NFHUN4cyQTB|NkW5OC=>
mouse NIH3T3 cells M{joXWZ2dmO2aX;uJIF{e2G7 NEfGd3QxNjFvMUCg{txO NH7ifGNVemGwc3HjeIl3[XSrb36gc4YhdW:3c3WgdoVkd22kaX7hcpQhWFCDUnHsdIhiKGW6cILld5Nm\CCrbjDtc5V{\SCQSVizWFMh[2WubIOgZZQhOC5zIIXNJJRwKDFyIIXNJIJ6KFCSUlWgZYN1cX[jdHnvckBj[XOnZDDkeYFtKGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTDy[YxifGm4ZTD0c{Bkd262cn;s M13EeFE6OjN5Mkiz
HepaR cells M4\vfWZ2dmO2aX;uJIF{e2G7 M2i0ZVI2KM7:TR?= Ml;oNUBl[Xl? NELHWm1C\2:waYP0JIFkfGm4aYT5JIF1KFCSQWLhcJBp[SCrbjDoeY1idiCKZYDhVkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCKTVfDV|Ih\2WwZTDlfJBz\XO|aX;uJIF1KDJ3IIXNJIlv[3WkYYTl[EBnd3JiMTDkZZkh[nlicYXhcpRqfGG2aY\lJHBEWiCvZYToc4QhemWuYYTpeoUhfG9idX70doVifGWmIHPvcpRzd2x? MWiyOVQ6PzF|Mh?=

... Click to View More Cell Line Experimental Data

In vivo WY 14643 (1 mg/kg i.v. bolus) administration at 30 min before left anterior descending occlusion, causes significant reduction in infarct size of ∼44% in rats subjected to regional myocardial ischemia (25 min) and reperfusion (2 h). [4] WY 14643 (3 mg/kg) lowers basal plasma levels of glucose, triglycerides (-16% vs. untreated), and leptin (-52%), and also muscle triglyceride (-34%) and total long-chain acyl-CoAs (LCACoAs) (-41%) in high fat-fed rats. WY14643 substantially reduces visceral fat weight and total liver triglyceride content without increasing body weight gain. WY14643 enhances whole body insulin sensitivity (clamp glucose infusion rate increases 35% and glucose disposals 22%, vs. untreated). WY 14643 enhances insulin-mediated muscle glucose metabolic index (Rg') in red (47%) and white (63%) muscles as well as in white adipose tissue (90%), and reduces muscle triglyceride and LCACoA accumulation. [5]

Protocol

Solubility (25°C)

In vitro DMSO 64 mg/mL (197.65 mM)
Ethanol 52 mg/mL (160.59 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+2% Tween 80+PBS
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 323.8
Formula

C14H14ClN3O2S

CAS No. 50892-23-4
Storage powder
in solvent
Synonyms NSC 310038
Smiles CC1=C(C)C(=CC=C1)NC2=NC(=NC(=C2)Cl)SCC(O)=O

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PPAR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID