WY-14643 (Pirinixic Acid)

Catalog No.S8029 Synonyms: NSC 310038

WY-14643 (Pirinixic Acid) Chemical Structure

Molecular Weight(MW): 323.8

WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with EC50 of 1.5 μM.

Size Price Stock Quantity  
In DMSO USD 190 In stock
USD 97 In stock
USD 310 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 1 Publication

1 Customer Review

  • (A) Acot1 mRNA following adenovirus treatments and 0.1% Wy-14643 supplementation (n=7-9). (B) H&E staining shows that Wy-14643 reduced and normalized lipid droplet accumulation in the Acot1 knockdown treatment group.

    Diabetes, 2017, 66(8):2112-2123. WY-14643 (Pirinixic Acid) purchased from Selleck.

Purity & Quality Control

Choose Selective PPAR Inhibitors

Biological Activity

Description WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with EC50 of 1.5 μM.
Targets
PPARα [1]
1.5 μM(EC50)
In vitro

WY 14643 (10 μM) almost completely inhibits interleukin-1-induced production of interleukin-6 and prostaglandin and expression of cyclooxygenase-2 in aortic smooth-muscle cells, through repression of NF-κB signaling. [2] WY14643 (250 μM) reduces VCAM-1 expression levels significantly, to 52 % of TNF-α-stimulated human endothelial cells. Pretreatment of endothelial cells with WY 14643 (10 μM) before TNF-α stimulation reduces U937 cell adhesion by 50%. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Hep G2 cells MVjGeY5kfGmxbjDhd5NigQ>? NX;S[oNwSWexbnnzeEBi[3Srdnn0fUBifCCvb4Xz[UBRWEGUYXzwbIEhdGmpYX7kJIJqdmSrbneg[I9u[WmwIHX4dJJme3OnZDDpckBpfW2jbjDI[ZAhTzJiY3XscJMh[29vdILhcpNn\WO2ZXSge4l1cCCJYXy0MWRDTCCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9NE4xPCEQvF2= M2q5O|E6ODV|N{e2
MCF7 cells M1LtbWZ2dmO2aX;uJIF{e2G7 NHvTUJNC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBRSVKjbIDoZUBmgHC{ZYPz[YQhcW5iTVPGO{Bk\WyuczDjc{11emGwc3\lZ5Rm\CCFUGTJJGRTOS22eYDlJHJGKGGodHXyJFYhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjV2MjFOwG0> NFzXXo8zPDl|NkKzNi=>
U2OS cells NEn2PYpHfW6ldHnvckBie3OjeR?= NIftRpdC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBRSVKjbIDoZUBqdiCXMl;TJINmdGy|IHL5JJRz[W6|YXP0bZZifGmxbjDhd5NigSxiRVO1NF0yOiEQvF2= MUmxPFMzQTd3MR?=
HEK293 cells MnXPSpVv[3Srb36gZZN{[Xl? NWGxT442SWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBRWEGUYXzwbIEh\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{Bkd3S{YX7z[oVkfGWmIIfpeIghWFCURYi0MXRMNWy3YzDhd5Nme3OnZDDhd{Bi[3SrdnH0bY9vKG:oIHz1Z4ln\XKjc3WgZYN1cX[rdImgcYVie3W{ZXSgZYZ1\XJiNEigbJJ{KGK7IITyZY5{[WO2aY\heIlwdiCjc4PhfUwhTUN3ME2yN{4{OyEQvF2= MXOyN|I3PTh2NB?=
COS7 cells NWLHd4VITnWwY4Tpc44h[XO|YYm= MYnBZ5RqfmG2aX;uJI9nKGi3bXHuJHBRSVKjbIDoZUBtcWejbnSgZolv\GmwZzDkc41icW5iZYjwdoV{e2WmIHnuJGNQWzdiY3XscJMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUO2MlMh|ryP MUCyOVA{PzlzNB?=
EAhy926 cells  MmfQSpVv[3Srb36gZZN{[Xl? NVnL[YxGOTBidV2= NGXPT5QyOiCq MYjJcohq[mm2aX;uJI9nKHS3YnWg[o9zdWG2aX;uJIlvKGi3bXHuJGVCcHl7Mk[gZ4VtdHNiYYSgNVAhfU1icILlMYlv[3WkYYTl[EBnd3JiMUKgbJJ{KG2nYYP1doVlKGGodHXyJFI1KGi{czDifUBxcGG|ZT3jc451emG|dDDtbYNzd3Olb4D5 MmXvNVkxOzZ3OUS=
mouse NIH3T3 cells NHj3dVJHfW6ldHnvckBie3OjeR?= M{fKeFAvOS1zMDFOwG0> NEjkVnJVemGwc3HjeIl3[XSrb36gc4YhdW:3c3WgdoVkd22kaX7hcpQhWFCDUnHsdIhiKGW6cILld5Nm\CCrbjDtc5V{\SCQSVizWFMh[2WubIOgZZQhOC5zIIXNJJRwKDFyIIXNJIJ6KFCSUlWgZYN1cX[jdHnvckBj[XOnZDDkeYFtKGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTDy[YxifGm4ZTD0c{Bkd262cn;s MlHXNVkzOzd{OEO=
HepaR cells MnizSpVv[3Srb36gZZN{[Xl? MYWyOUDPxE1? MYexJIRigQ>? M1nYVGFod26rc4SgZYN1cX[rdImgZZQhWFCDUnHsdIhiKGmwIHj1cYFvKEincHHSJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKEiPR1PTNkBo\W6nIHX4dJJme3Orb36gZZQhOjVidV2gbY5kfWKjdHXkJIZweiBzIHThfUBjgSCzdXHueIl1[XSrdnWgVGNTKG2ndHjv[EBz\WyjdHn2[UB1dyC3boTy[YF1\WRiY3;ueJJwdA>? NG\Sc|UzPTR7N{GzNi=>

... Click to View More Cell Line Experimental Data

In vivo WY 14643 (1 mg/kg i.v. bolus) administration at 30 min before left anterior descending occlusion, causes significant reduction in infarct size of ∼44% in rats subjected to regional myocardial ischemia (25 min) and reperfusion (2 h). [4] WY 14643 (3 mg/kg) lowers basal plasma levels of glucose, triglycerides (-16% vs. untreated), and leptin (-52%), and also muscle triglyceride (-34%) and total long-chain acyl-CoAs (LCACoAs) (-41%) in high fat-fed rats. WY14643 substantially reduces visceral fat weight and total liver triglyceride content without increasing body weight gain. WY14643 enhances whole body insulin sensitivity (clamp glucose infusion rate increases 35% and glucose disposals 22%, vs. untreated). WY 14643 enhances insulin-mediated muscle glucose metabolic index (Rg') in red (47%) and white (63%) muscles as well as in white adipose tissue (90%), and reduces muscle triglyceride and LCACoA accumulation. [5]

Protocol

Solubility (25°C)

In vitro DMSO 64 mg/mL (197.65 mM)
Ethanol 52 mg/mL (160.59 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+2% Tween 80+PBS
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 323.8
Formula

C14H14ClN3O2S

CAS No. 50892-23-4
Storage powder
in solvent
Synonyms NSC 310038

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

PPAR Signaling Pathway Map

Related PPAR Products0

Tags: buy WY-14643 (Pirinixic Acid) | WY-14643 (Pirinixic Acid) supplier | purchase WY-14643 (Pirinixic Acid) | WY-14643 (Pirinixic Acid) cost | WY-14643 (Pirinixic Acid) manufacturer | order WY-14643 (Pirinixic Acid) | WY-14643 (Pirinixic Acid) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID