WY-14643 (Pirinixic Acid)

For research use only.

Catalog No.S8029 Synonyms: NSC 310038

11 publications

WY-14643 (Pirinixic Acid) Chemical Structure

CAS No. 50892-23-4

WY 14643 (Pirinixic Acid, NSC 310038) is a potent peroxisome proliferator and activator of PPARα with EC50 of 1.5 μM.

Selleck's WY-14643 (Pirinixic Acid) has been cited by 11 publications

1 Customer Review

  • (A) Acot1 mRNA following adenovirus treatments and 0.1% Wy-14643 supplementation (n=7-9). (B) H&E staining shows that Wy-14643 reduced and normalized lipid droplet accumulation in the Acot1 knockdown treatment group.

    Diabetes, 2017, 66(8):2112-2123. WY-14643 (Pirinixic Acid) purchased from Selleck.

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Biological Activity

Description WY 14643 (Pirinixic Acid, NSC 310038) is a potent peroxisome proliferator and activator of PPARα with EC50 of 1.5 μM.
PPARα [1]
1.5 μM(EC50)
In vitro

WY 14643 (10 μM) almost completely inhibits interleukin-1-induced production of interleukin-6 and prostaglandin and expression of cyclooxygenase-2 in aortic smooth-muscle cells, through repression of NF-κB signaling. [2] WY14643 (250 μM) reduces VCAM-1 expression levels significantly, to 52 % of TNF-α-stimulated human endothelial cells. Pretreatment of endothelial cells with WY 14643 (10 μM) before TNF-α stimulation reduces U937 cell adhesion by 50%. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Hep G2 cells NF\qNZZHfW6ldHnvckBie3OjeR?= M2CxOGFod26rc4SgZYN1cX[rdImgZZQhdW:3c3WgVHBCWmGucHjhJIxq\2GwZDDibY5lcW6pIHTvcYFqdiCneIDy[ZN{\WRiaX6gbJVu[W5iSHXwJGczKGOnbHzzJINwNXS{YX7z[oVkfGWmIIfpeIghT2GuND3ERmQh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUCuNFQh|ryP MoLkNVkxPTN5N{[=
MCF7 cells NEGxSpJHfW6ldHnvckBie3OjeR?= NUT2fnlKSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBRWEGUYXzwbIEh\XiycnXzd4VlKGmwIF3DSlch[2WubIOgZ48ufHKjboPm[YN1\WRiQ2DUTUBFWjFvdInw[UBTTSCjZoTldkA3KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC53NEKg{txO M4nj[|I1QTN4MkOy
U2OS cells M2qyeGZ2dmO2aX;uJIF{e2G7 NEHa[YJC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBRSVKjbIDoZUBqdiCXMl;TJINmdGy|IHL5JJRz[W6|YXP0bZZifGmxbjDhd5NigSxiRVO1NF0yOiEQvF2= M{jXW|E5OzJ7N{Wx
HEK293 cells NF7LdFNHfW6ldHnvckBie3OjeR?= NFrmfHFC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBRSVKjbIDoZUBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJINwfHKjboPm[YN1\WRid3n0bEBRWFKHeEStWGsudHWlIHHzd4V{e2WmIHHzJIFkfGm4YYTpc44hd2ZibIXjbYZmemG|ZTDhZ5Rqfmm2eTDt[YF{fXKnZDDh[pRmeiB2ODDodpMh[nlidILhcpNi[3SrdnH0bY9vKGG|c3H5MEBGSzVyPUKzMlM{KM7:TR?= NX3ZU4l2OjN{NkW4OFQ>
COS7 cells M4jpTWZ2dmO2aX;uJIF{e2G7 M3nRbmFkfGm4YYTpc44hd2ZiaIXtZY4hWFCDUnHsdIhiKGyrZ3Hu[EBjcW6maX7nJIRwdWGrbjDlfJBz\XO|ZXSgbY4hS0:VNzDj[YxteyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9N|YvOyEQvF2= NXr5Z5NFOjVyM{e5NVQ>
EAhy926 cells  M{KzbWZ2dmO2aX;uJIF{e2G7 NY\2blMyOTBidV2= NWj2cXYxOTJiaB?= M3TIb2lvcGmkaYTpc44hd2ZidIXi[UBnd3KvYYTpc44hcW5iaIXtZY4hTUGqeUmyOkBk\WyuczDheEAyOCC3TTDwdoUucW6ldXLheIVlKG[xcjCxNkBpenNibXXhd5Vz\WRiYX\0[ZIhOjRiaILzJIJ6KHCqYYPlMYNwdnS{YYP0JI1q[3Kxc3PvdJk> NHqxdJgyQTB|NkW5OC=>
mouse NIH3T3 cells NH\wUlVHfW6ldHnvckBie3OjeR?= MWSwMlEuOTBizszN Mn3xWJJidnOjY4TpeoF1cW:wIH;mJI1wfXOnIILlZ49u[mmwYX70JHBRSVKjbIDoZUBmgHC{ZYPz[YQhcW5ibX;1d4UhVkmKM2SzJINmdGy|IHH0JFAvOSC3TTD0c{AyOCC3TTDifUBRWFKHIHHjeIl3[XSrb36gZoF{\WRiZIXhcEBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XlicnXsZZRqfmVidH:gZ49vfHKxbB?= MmnaNVkzOzd{OEO=
HepaR cells NWjXZmlQTnWwY4Tpc44h[XO|YYm= NXPqNnlrOjVizszN NFvneZAyKGSjeR?= NED6OFBC\2:waYP0JIFkfGm4aYT5JIF1KFCSQWLhcJBp[SCrbjDoeY1idiCKZYDhVkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCKTVfDV|Ih\2WwZTDlfJBz\XO|aX;uJIF1KDJ3IIXNJIlv[3WkYYTl[EBnd3JiMTDkZZkh[nlicYXhcpRqfGG2aY\lJHBEWiCvZYToc4QhemWuYYTpeoUhfG9idX70doVifGWmIHPvcpRzd2x? NX:2U|V2OjV2OUexN|I>

... Click to View More Cell Line Experimental Data

In vivo WY 14643 (1 mg/kg i.v. bolus) administration at 30 min before left anterior descending occlusion, causes significant reduction in infarct size of ∼44% in rats subjected to regional myocardial ischemia (25 min) and reperfusion (2 h). [4] WY 14643 (3 mg/kg) lowers basal plasma levels of glucose, triglycerides (-16% vs. untreated), and leptin (-52%), and also muscle triglyceride (-34%) and total long-chain acyl-CoAs (LCACoAs) (-41%) in high fat-fed rats. WY14643 substantially reduces visceral fat weight and total liver triglyceride content without increasing body weight gain. WY14643 enhances whole body insulin sensitivity (clamp glucose infusion rate increases 35% and glucose disposals 22%, vs. untreated). WY 14643 enhances insulin-mediated muscle glucose metabolic index (Rg') in red (47%) and white (63%) muscles as well as in white adipose tissue (90%), and reduces muscle triglyceride and LCACoA accumulation. [5]


Solubility (25°C)

In vitro DMSO 64 mg/mL (197.65 mM)
Ethanol 52 mg/mL (160.59 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 323.8


CAS No. 50892-23-4
Storage powder
in solvent
Synonyms NSC 310038
Smiles CC1=C(C(=CC=C1)NC2=CC(=NC(=N2)SCC(=O)O)Cl)C

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PPAR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID