WAY-316606

Catalog No.S5815

For research use only.

WAY-316606, a specific antagonist of SFRP1, functions as an activator of canonical Wnt/β-catenin signalling in the human hair bulb.

WAY-316606 Chemical Structure

CAS No. 915759-45-4

Selleck's WAY-316606 has been cited by 1 Publication

Purity & Quality Control

Choose Selective SFRP Inhibitors

Biological Activity

Description WAY-316606, a specific antagonist of SFRP1, functions as an activator of canonical Wnt/β-catenin signalling in the human hair bulb.
Targets
sFRP1 [1]
()
In vitro

WAY-316606 enhances hair shaft production, hair shaft keratin expression, and inhibits spontaneous HF regression (catagen) ex vivo. WAY-316606 effectively enhances β-catenin activity in mammalian skin cell populations, namely in both human hair pre-cortex keratinocytes and DP fibroblasts ex vivo[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
U2OS MlrWSpVv[3Srb36gZZN{[Xl? Mn7XNVYhfG9iMUigbJJ{ NULSSpVCSW62YXfvcol{fCCjY4Tpeol1gSCjdDDoeY1idiCZTmSzJIV5eHKnc4Pl[EBqdiCqdX3hckBWOk:VIHPlcIx{KGG|c3Xzd4VlKGG|IGfueEB{cWewYXzpcoch[W[2ZYKgNVYhfG9iMUigbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2wMlY2|ryP MmPFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{K1OFAoRjF7MEeyOVQxRC:jPh?=
U2OS NEnBVZZHfW6ldHnvckBie3OjeR?= NULsXnhJOTZidH:gNVghcHK| MVXBcpRi\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHdPXDNiZYjwdoV{e2WmIHnuJIh2dWGwIGWyU3Mh[2WubIOgZZN{\XO|ZXSgZZMhOiCob3zkJIlv[3KnYYPlJIlvKFewdDDzbYdv[WyrbnegZYZ1\XJiMU[geI8hOThiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygRYN1cX[rdIm9NE44Pc7:TR?= M2HHZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEeyOVQxLz5zOUC3NlU1ODxxYU6=

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 90 mg/mL
(200.67 mM)
Water Insoluble
Ethanol '7 mg/mL

Chemical Information

Molecular Weight 448.48
Formula

C18H19F3N2O4S2

CAS No. 915759-45-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CNCCC1NS(=O)(=O)C2=C(C=CC(=C2)S(=O)(=O)C3=CC=CC=C3)C(F)(F)F

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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