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Succimer

Cat.No.S4692

Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) is an orally active metal chelator is used to treat heavy metal poisoning.
Succimer Chemical Structure

Chemical Structure

Molecular Weight: 182.22

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S469201 DMSO]36 mg/mL]false]Ethanol]3 mg/mL]false]Water]Insoluble]false Purity: 99.51%
99.51

Chemical Information, Storage & Stability

Molecular Weight 182.22 Formula

C4H6O4S2

 Storage (From the date of receipt)
CAS No. 304-55-2 -- Storage of Stock Solutions

Synonyms DMSA, meso-2,3-dimercaptosuccinic acid Smiles C(C(C(=O)O)S)(C(=O)O)S

Solubility

In vitro
Batch:

DMSO : 36 mg/mL (197.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03653702 Not yet recruiting
Vesico-Ureteral Reflux
Boston Children''s Hospital
 October 1 2023 Phase 1
NCT05595863 Not yet recruiting
Brain Glioma
Assiut University
 November 2022 --
NCT05593809 Not yet recruiting
Brain Glioma
Assiut University
 October 2022 --
NCT04091685 Unknown status
Dimercaptosuccinic Acid SPECT and Planar
Assiut University
 September 2019 --
NCT03959163 Recruiting
Pyelonephritis|Pyelonephritis Acute|Renal Sclerosis
University of Wisconsin Madison
 May 7 2019 Not Applicable
NCT03879005 Unknown status
The Difference in Estimation of Split Renal Function Using the Two Radiopharmaceuticals:Tc-99m DTPA & Tc-99m DMSA in Kidney Patients
Assiut University
 April 2019 Not Applicable

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