For research use only.

Catalog No.S7617 Synonyms: ABR-215050

12 publications

Tasquinimod Chemical Structure

CAS No. 254964-60-8

Tasquinimod (ABR-215050) is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. Phase 3.

Selleck's Tasquinimod has been cited by 12 publications

1 Customer Review

  • Western blot images suggested inhibition of HDAC4 increased the expression of NOX4 and MMP-9, and treatment with 10 μM SCM-198 reduced the raised levels of NOX4 and MMP-9.

    Oxid Med Cell Longev, 2017, doi: 10.1155/2017/7150376 . Tasquinimod purchased from Selleck.

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Biological Activity

Description Tasquinimod (ABR-215050) is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. Phase 3.
HDAC4 [1]
In vitro

Tasquinimod inhibits tumor angiogenesis by allosteric inhibition of HDAC4/N-CoR/HDAC3 dependent deacetylation of HIF-1α. [1] Tasquinimod also targets infiltrating myeloid cells, and modulates local tumour immunity by blocking the interaction between S100A9 and its ligands receptor of advanced glycation end products and Toll-like receptor 4. [3]

In vivo Tasquinimod (30 mg/kg/d p.o.) shows anti-angiogenic activity and thus causes tumor growth inhibition in mice bearing human and rodent prostate cancer models. [2]


Animal Research:


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  • Animal Models: Mice bearing PC-82 , CWR-22Rv1, LAPC-4, or LNCaP prostate cancer xenografts.
  • Dosages: ~30 mg/kg/d
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 81 mg/mL (199.33 mM)
Ethanol 11 mg/mL warmed (27.06 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 406.36


CAS No. 254964-60-8
Storage powder
in solvent
Synonyms ABR-215050
Smiles CN1C2=C(C(=CC=C2)OC)C(=C(C1=O)C(=O)N(C)C3=CC=C(C=C3)C(F)(F)F)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02396368 Withdrawn Drug: Tasquinimod|Radiation: Radium 223 Prostate Cancer|Bone-only Metastatic Castration-Resistant Prostate Cancer (CRPC) Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins March 2015 Phase 1
NCT02057666 Terminated Drug: Tasquinimod|Drug: Placebo Prostatic Neoplasms Castration-Resistant Ipsen January 2014 Phase 3
NCT01732549 Terminated Drug: Tasquinimod|Drug: Placebo Metastatic Castrate Resistant Prostate Cancer Ipsen January 2013 Phase 2
NCT01234311 Completed Drug: tasquinimod|Drug: Placebo Prostate Cancer Active Biotech AB March 2011 Phase 3

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HDAC Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID