HDAC7 Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S8502 TMP195

TMP195 (TFMO 2) is a selective, first-in-class, class IIa HDAC inhibitor with IC50 of 300 nM in cell-based class IIa HDAC assays.

Pan HDAC7, Ki: 26 nM; HDAC7, Ki: 26 nM
S7324 TMP269

TMP269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.

Pan HDAC7, IC50: 43 nM; HDAC7, IC50: 43 nM
S1515 Pracinostat (SB939)

Pracinostat (SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6. It has no activity against the class III isoenzyme SIRT I. Pracinostat (SB939) induces apoptosis in tumor cells. Phase 2.

Pan HDAC7, IC50: 137 nM
S1194 CUDC-101

CUDC-101 is a potent multi-targeted inhibitor against HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, and inhibits class I/II HDACs, but not class III, Sir-type HDACs. Phase 1.

Pan HDAC7, IC50: 373 nM