Home Transmembrane Transporters GABA Receptor agonist 6-Hydroxyflavone (6-HF)

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6-Hydroxyflavone (6-HF) GABA Receptor agonist

Cat.No.S3634

6-Hydroxyflavone, a naturally occurring flavonoid, binds to GABAA receptors with moderate affinity and acts as a partial agonist of GABAA receptors.
6-Hydroxyflavone (6-HF) GABA Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 238.24

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Quality Control

Batch: S363401 DMSO]47 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.96%
99.96

Solubility

In vitro
Batch:

DMSO : 47 mg/mL (197.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 238.24 Formula

C15H10O3

 Storage (From the date of receipt)
CAS No. 6665-83-4 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=CC(=C3)O

Mechanism of Action

Targets/IC50/Ki
GABAA receptor
In vitro
6HF binds to GABAA receptors with moderate affinity.
In vivo
In mice, 6HF exhibits anxiolytic-like effect in the elevated plus-maze test, unaccompanied at anxiolytic doses by the sedative, cognitive impairing, myorelaxant, motor incoordination and anticonvulsant effects commonly associated with classical BZs when tested in the hole-board, step-through passive avoidance, horizontal wire, rotarod, and pentylenetetrazol (PTZ)-induced seizure tests, respectively.
References

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