Gabapentin HCl

Licensed by Pfizer Catalog No.S1338

Gabapentin HCl Chemical Structure

Molecular Weight(MW): 207.7

Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain.

Size Price Stock Quantity  
USD 70 In stock
USD 270 In stock
USD 570 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective GABA Receptor Inhibitors

Biological Activity

Description Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain.
Targets
GABA receptor [1]
In vitro

Gabapentin suppresses ectopic afferent discharge activity generated from injured peripheral nerves. Gabapentin, in a range of 30 to 90 mg/kg, significantly attenuates allodynia in nerve-injured rats. Gabapentin dose-dependently inhibits the ectopic discharge activity of 15 injured sciatic afferent nerve fibers through an action on impulse generation. [1] Gabapentin inhibits KCl (30 mM)-evoked voltage-dependent Ca(2+) influx. Gabapentin potently inhibits the peak whole-cell Ca(2+) channel current (I(Ba)) in a dose-dependent manner with an estimated IC(50) value of 167 nM. Gabapentin inhibition is voltage-dependent, producing an approximately 7 mV hyperpolarizing shift in current voltage properties and reducing a non-inactivating component of whole-cell current activated at relatively depolarized potentials. [2] Gabapentin selectively activates heterodimeric GABAB1a-B2 receptors, but not GABAB1b-B2 or GABAB1c-B2 receptors. Gabapentin selectively activates presynaptic GABAB heteroreceptors on glutamatergic terminals, but not GABAB autoreceptors on GABAergic terminals. Gabapentin is found to inhibit both the excitatory synaptic transmission in vitro and the neuronal response to noxious electrical and mechanical stimulation in vivo mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), but not those mediated by N-methyl-D-asparate (NMDA) receptors. Gabapentin acts as an AMPA-receptor antagonist in the rat spinal cord to exert its spinal antinociceptive effect. Gabapentin depresses, but NMDA enhanced, the presynaptic fiber volley in the CA1 region of rat hippocampal slices. [3]

Protocol

Solubility (25°C)

In vitro Water 42 mg/mL (202.21 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 207.7
Formula

C9H17NO2.HCl

CAS No. 60142-95-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04068506 Recruiting Drug: Gabapentin 600 mg Tab Hand Injuries Dow University of Health Sciences September 1 2019 Phase 4
NCT03867240 Recruiting Drug: Gabapentin|Other: Placebo Pain Postoperative|Scoliosis Idiopathic Emory University June 25 2019 Phase 3
NCT03747562 Not yet recruiting Drug: Gabapentin|Other: Placebo Head Neck Cancer|Radiation Neuropathy|Pain Neuropathic University Hospital Ghent|General Hospital Groeninge|Catholic University Leuven department Kortrijk (KULAK) Kortrijk Belgium|Anglia Ruskin University March 1 2019 Phase 3
NCT03708237 Recruiting Drug: Ropinirole|Drug: Gabapentin|Drug: Placebos Restless Legs Syndrome|End Stage Renal Disease University of Alberta February 19 2019 Phase 2
NCT03583892 Recruiting Drug: Gabapentin Pain Postoperative Centro Hospitalar do Porto July 1 2018 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

GABA Receptor Signaling Pathway Map

Related GABA Receptor Products

Tags: buy Gabapentin HCl | Gabapentin HCl ic50 | Gabapentin HCl price | Gabapentin HCl cost | Gabapentin HCl solubility dmso | Gabapentin HCl purchase | Gabapentin HCl manufacturer | Gabapentin HCl research buy | Gabapentin HCl order | Gabapentin HCl mouse | Gabapentin HCl chemical structure | Gabapentin HCl mw | Gabapentin HCl molecular weight | Gabapentin HCl datasheet | Gabapentin HCl supplier | Gabapentin HCl in vitro | Gabapentin HCl cell line | Gabapentin HCl concentration | Gabapentin HCl nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID