Home Neuronal Signaling GABA Receptor agonist (R)-baclofen

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(R)-baclofen GABA Receptor agonist

Cat.No.S3072

(R)-baclofen (STX 209) is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.
(R)-baclofen GABA Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 213.66

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Quality Control

Batch: S307201 Water]8 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.72%
99.72

Solubility

In vitro
Batch:

Water : 8 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 213.66 Formula

C10H12ClNO2

 Storage (From the date of receipt)
CAS No. 69308-37-8 Download SDF Storage of Stock Solutions

Synonyms STX 209 SMILES C1=CC(=CC=C1C(CC(=O)O)CN)Cl

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Mechanism of Action

Targets/IC50/Ki
GABAB receptor
In vitro
Baclofen is a skeletal muscle relaxant used in the treatment of spasticity of spinal and cerebral origin. Although it is marketed as a racemic mixture, only the baclofen R-enantiomer is stereospecifically active at so called GAGAB-receptors. Researchers believe that the enantiomers of baclofen have different properties. It is claimed that the R-(−)-enantiomer is about 100 times more active than the S-(+)-enantiomer.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-05-13)

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NCT06564714 NOT_YET_RECRUITING
Traumatic Spinal Cord Injury
Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
 2024-12 PHASE4
NCT05935553 RECRUITING
Benzodiazepine Dependence
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 2026-01-15 PHASE2; PHASE3
NCT07378046 RECRUITING
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 2025-12-15

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