Home Neuronal Signaling GABA Receptor agonist (R)-baclofen

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(R)-baclofen GABA Receptor agonist

Cat.No.S3072

(R)-baclofen (STX 209) is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.
(R)-baclofen GABA Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 213.66

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Quality Control

Batch: S307201 Water]8 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.72%
99.72

Chemical Information, Storage & Stability

Molecular Weight 213.66 Formula

C10H12ClNO2

 Storage (From the date of receipt)
CAS No. 69308-37-8 Download SDF Storage of Stock Solutions

Synonyms STX 209 Smiles C1=CC(=CC=C1C(CC(=O)O)CN)Cl

Solubility

In vitro
Batch:

Water : 8 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

Targets/IC50/Ki
GABAB receptor [1]
In vitro
Baclofen is a skeletal muscle relaxant used in the treatment of spasticity of spinal and cerebral origin. Although it is marketed as a racemic mixture, only the baclofen R-enantiomer is stereospecifically active at so called GAGAB-receptors. [1] Researchers believe that the enantiomers of baclofen have different properties. It is claimed that the R-(−)-enantiomer is about 100 times more active than the S-(+)-enantiomer.
References

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