(R)-baclofen

Catalog No.S3072 Synonyms: STX 209

For research use only.

(R)-baclofen (STX 209) is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.

(R)-baclofen Chemical Structure

CAS No. 69308-37-8

Selleck's (R)-baclofen has been cited by 1 Publication

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Biological Activity

Description (R)-baclofen (STX 209) is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.
Targets
GABAB receptor [1]
In vitro

Baclofen is a skeletal muscle relaxant used in the treatment of spasticity of spinal and cerebral origin. Although it is marketed as a racemic mixture, only the baclofen R-enantiomer is stereospecifically active at so called GAGAB-receptors. [1] Researchers believe that the enantiomers of baclofen have different properties. It is claimed that the R-(−)-enantiomer is about 100 times more active than the S-(+)-enantiomer.

Protocol (from reference)

Solubility (25°C)

In vitro

Water 8 mg/mL
(37.44 mM)
DMSO Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 213.66
Formula

C10H12ClNO2

CAS No. 69308-37-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=CC=C1C(CC(=O)O)CN)Cl

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