Home Neuronal Signaling GABA Receptor antagonist Pentylenetetrazol For research use only.

Pentylenetetrazol

Synonyms: Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ

Pentylenetetrazol (Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ) displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist.

Pentylenetetrazol Chemical Structure

Pentylenetetrazol Chemical Structure

CAS: 54-95-5

Selleck's Pentylenetetrazol has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.69%
99.69

Pentylenetetrazol Related Products

Signaling Pathway

GABA Receptor Signaling Pathways

GABA Receptor Signaling Pathway

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Biological Activity

Description Pentylenetetrazol (Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ) displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist.
Targets
GABA receptor [1]
In Vivo
In vivo Administration of PTZ (45 mg/kg i.p.) induces clonic convulsions in almost all of the animals after a single injection, typically within 3 min. However, 11% of animals need a second injection to cause clonus. Each rat shows jerking or myoclonus followed by clonus or tonic-clonic convulsions. PTZ injection results in significant changes in GABAA receptor subunit mRNAs. A single PTZ-induced convulsion is associated with rapid changes in GABAA receptors[1].
Animal Research Animal Models Male Sprague-Dawley rats
Dosages 45 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 138.17 Formula

C6H10N4
CAS No. 54-95-5 SDF Download Pentylenetetrazol SDF
Smiles C1CCC2=NN=NN2CC1
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 28 mg/mL ( (202.64 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 28 mg/mL

Ethanol : 28 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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