Home Neuronal Signaling GABA Receptor modulator Homotaurine

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Homotaurine GABA Receptor modulator

Cat.No.S5131

Homotaurine (Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid) is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy.
Homotaurine GABA Receptor modulator Chemical Structure

Chemical Structure

Molecular Weight: 139.17

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Quality Control

Batch: S513101 Water]27 mg/mL]false]DMSO]Insoluble]false]]]false Purity: 98%
98

Chemical Information, Storage & Stability

Molecular Weight 139.17 Formula

C3H9NO3S

 Storage (From the date of receipt)
CAS No. 3687-18-1 Download SDF Storage of Stock Solutions

Synonyms Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid Smiles C(CN)CS(=O)(=O)O

Solubility

In vitro
Batch:

Water : 27 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

Targets/IC50/Ki
GABA receptor [1]
In vitro
Homotaurine is a small aminosulfonate compound naturally found in seaweeds. It is a compound with features typical of glycosaminoglycanes (GAGs). This compound has been shown to be able to counteract Aβ fibrillogenesis reducing the toxic effects on neurons. Besides the anti-amyloid action, it has direct effects also on neuronal activity as a modulator of excitatory neurotransmission, due to its binding affinity for GABAA receptors (GABAARs)[1].
In vivo
In experimental models homotaurine administration induced inhibition of Aβ fibrils formation, reduction of the brain pathologic burden, and formation of physiological LTP[1].
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04422743 Terminated
Glaucoma
IRCCS Policlinico S. Matteo
 January 25 2018 Not Applicable
NCT04157712 Completed
Alzheimer Disease
Alzheon Inc.|Quotient Clinical
 September 26 2015 Phase 1
NCT00314912 Unknown status
Alzheimer''s Disease
Bellus Health Inc. - a GSK company
 May 2006 Phase 3

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