3,4,5-Trimethoxycinnamic acid

For research use only.

Catalog No.S4961

3,4,5-Trimethoxycinnamic acid Chemical Structure

CAS No. 90-50-6

3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex.

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Biological Activity

Description 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex.
Targets
GABA receptor [1]
()
In vivo TMCA decreased the locomotor activity in mice, prolonged total sleep time, and reduced sleep latency induced by pentobarbital. TMCA also increased the total sleep time and non-rapid eye movement (NREM) sleep. It alters sleep architecture through GABAAergic systyems[1]. TMCA exhibits anti-stress actions by the suppression of norepinephrine (NE) content in locus coeruleus (LC) induced by corticotrophin-releasing hormone (CRH)[2].

Protocol

Animal Research:

[1]

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  • Animal Models: ICR male mice
  • Dosages: 2.0, 5.0 and 10 mg/kg
  • Administration: p.o
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 47 mg/mL (197.28 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 238.24
Formula

C12H14O5

CAS No. 90-50-6
Storage powder
in solvent
Synonyms N/A
Smiles COC1=CC(=CC(=C1OC)OC)C=CC(=O)O

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID