Tiagabine

For research use only.

Catalog No.S4675 Synonyms: Gabitril, NO050328, NO328, TGB

Tiagabine Chemical Structure

CAS No. 115103-54-3

Tiagabine (Gabitril, NO050328, NO328, TGB) is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.

Purity & Quality Control

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Biological Activity

Description Tiagabine (Gabitril, NO050328, NO328, TGB) is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
Targets
GABA reuptake [1]
In vitro

Tiagabine is a potent inhibitor of GABA uptake into neurons and glial cells. It is involved in modulating GABA levels, especially in areas such as the hippocampus and thalamus[2]. Tiagabine not only affected the decay kinetics of the IPSCs, it also reduced the frequency of occurrence of both spontaneous and miniature IPSCs[1].

In vivo Tiagabine offers a significant neuroprotection in global ischemia in gerbils when given 30 min before ischemia but not when given 3 h after ischemia[3].

Protocol

Animal Research:[1]
- Collapse
  • Animal Models: Male adult Sprague-Dawley rats
  • Dosages: 0.2 μmol
  • Administration: microinjected unilaterally into the globus pallidus
    (Only for Reference)

Solubility (25°C)

Chemical Information

Molecular Weight 375.55
Formula

C20H25NO2S2

Density 1.208 g/mL
CAS No. 115103-54-3
Storage 2 years 4°C liquid
Synonyms Gabitril, NO050328, NO328, TGB
Smiles CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(=O)O)C3=C(C=CS3)C

In vivo Formulation Calculator (Clear solution)

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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04455841 Recruiting Drug: INCB000928|Drug: ruxolitinib Anemia|Post-essential Thrombocythemia Myelofibrosis|Post-polycythemia Vera Myelofibrosis Incyte Corporation March 19 2021 Phase 1|Phase 2
NCT04021355 Recruiting Other: Oral sodium supplementation Obesity|Hypertension|Circadian Dysregulation|Salt; Excess University of Alabama at Birmingham July 14 2020 Not Applicable
NCT01904487 Completed Radiation: [11C]flumazenil|Drug: Tiagabine Alcoholism Rajesh Narendran|University of Pittsburgh April 19 2011 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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GABA Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID