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United States
DNA/RNA Synthesis Inhibitors
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
|---|---|---|---|---|
| S1166 | Cisplatin | Cisplatin is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation. |
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| S1714 | Gemcitabine | Gemcitabine, a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis. |
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| S1209 | 5-Fluorouracil (5-FU) | 5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV. |
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| S1224 | Oxaliplatin | Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation. |
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| S1149 | Gemcitabine Hydrochloride | Gemcitabine is a pyrimidine nucleoside analog antitumor drug that can inhibit DNA synthesis and repair, leading to cell autophagy and apoptosis. It is mainly used to treat various solid tumors such as pancreatic cancer and non-small cell lung cancer, and is often combined with chemotherapy to enhance efficacy. |
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| S1648 | Cytarabine | Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis. |
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| S2684 | CX-5461 (Pidnarulex) | CX-5461 (Pidnarulex) is an inhibitor of rRNA synthesis that selectively inhibits Pol I-driven transcription of rRNA with an IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells. It has no effect on Pol II and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation. |
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| S1229 | Fludarabine (NSC 118218) Phosphate | Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis. |
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| S1896 | Hydroxyurea | Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection. |
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| S7742 | SCR7 | SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ). It increases the efficiency of HDR-mediated genome editing up to 19-fold using CRISPR/Cas9 in mammalian cells and mouse embryos. |
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| S2794 | Sofosbuvir | Sofosbuvir is a HCV NS5B polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection. |
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| S1156 | Capecitabine | Capecitabine is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis. |
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| S7975 | Favipiravir (T-705) | Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections. |
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| S8246 | RK-33 | RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells. |
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| S7718 | BMH-21 | BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. |
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| S5582 | Cytarabine hydrochloride | Cytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. |
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| S7470 | Triapine (3-AP) | Triapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2. |
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| S1289 | Carmofur | Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. |
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| S1217 | Cyclophosphamide | Cyclophosphamide(NSC 26271,Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane) is a nitrogen mustard alkylating agent from the oxazophorines group. |
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| S1213 | Nelarabine | Nelarabine (506U78,Arranon) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. |
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| S1305 | Mercaptopurine (6-MP) | Mercaptopurine (6-MP) is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. |
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| S7679 | YK-4-279 | YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA). |
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| S1299 | Floxuridine (FUDR) | Floxuridine (FUDR), a prodrug that is rapidly catabolized to 5-fluorouracil in vivo, is used to treat various cancers, particularly metastases to the liver. It inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. This compound also has antiviral effects against HSV and CMV. |
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| S4288 | Chloroambucil | Chloroambucil (Chlorambucil,CB-1348,WR-139013) is a nitrogen mustard alkylating agent, used in the treatment of chronic lymphocytic leukemia. |
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| S1384 | Mizoribine | Mizoribine is an imidazole nucleoside and an immunosuppressant that inhibits HCV RNA replication with IC50 of ~ 100 μM for anti-HCV activity. This compound is a selective inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase. It also inhibits SARS-CoV. |
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| S1300 | Tegafur (FT-207) | Tegafur (NSC 148958,Fluorafur,FT-207) is a substance being used in the treatment of some types of cancer. |
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| S8144 | Halofuginone | Halofuginone (RU-19110) is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal. |
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| S1995 | Procarbazine HCl | Procarbazine HCl (NSC-77213) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma. |
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| S4227 | Fidaxomicin | Fidaxomicin is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit. |
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| S4239 | Bergapten | Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication. |
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| S1516 | Cidofovir | Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis. |
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| S8850 | JH-RE-06 | JH-RE-06 is a potent REV1-REV7 interface inhibitor with an IC50 of 0.78 μM and Kd value of 0.42 μM, disrupting REV1-POL ζ-mediated mutagenic translesion synthesis (TLS). |
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| S4030 | Gentamicin Sulfate | Gentamycin Sulfate (NSC-82261, SCH9724) is a broad-spectrum, aminoglycoside antibiotic used for cell culture which inhibits protein synthesis in sensitive organisms.Gentamicin Sulfate can be used to induce animal models of Renal Failure. |
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| S7757 | 6-Thio-dG | 6-thio-dG (β-TGdR) is a nucleoside analog and telomerase substrate. |
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| E1331 | SU056 | SU056 is an inhibitor of Y box binding protein 1 (YB-1) with IC50 of 1.73 μM in Sk0V3 cells. |
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| S1760 | Rifapentine | Rifapentine (MDL473) is an antibiotic, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis. |
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| S1826 | Nedaplatin | Nedaplatin (NSC 375101D) is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation. |
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| S4297 | Mupirocin | Mupirocin(BRL-4910A,Pseudomonic acid) is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections. |
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| S1973 | Cyclocytidine HCl | Cyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia. |
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| S7445 | APX-3330 | APX-3330 (E3330) is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. |
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| S3669 | Carmustine | Carmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms. |
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| S7546 | Pritelivir (BAY 57-1293) | Pritelivir (BAY 57-1293, AIC316) is a potent helicase primase inhibitor that exhibits antiviral effects on herpes simplex virus (HSV), with an IC50 of 20 nM for both HSV-1 and HSV-2. |
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| S1784 | Vidarabine | Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses. |
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| S3001 | Clevudine | Clevudine(Levovir,L-FMAU) is an antiviral drug for the treatment of hepatitis B. |
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| E1070 | Phen-DC3 Trifluoromethanesulfonate | Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65 ± 6 and 50 ± 10 nM, respectively. |
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| S0469 | ML216 | ML216 (CID-49852229) is a potent and selective inhibitor of the DNA unwinding activity of BLM(Bloom’s syndrome protein) with antitumor activity. This compound inhibits helicases with IC50 of 0.97 μM and 2.98 μM for BLM636-1298 and BLMfull-length, respectively. |
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| E2939 | Didox | Didox (3,4-dihydroxy-benzohydroxamic acid) is a synthetic ribonucleotide reductase (RR) inhibitor derived from polyhydroxy-substituted benzohydroxamic acid. This compound inhibits proliferation of resistant breast cancer cells. |
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| E1152 | AGX51 | AGX51, a first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader, inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and reduces viability, also inhibits pathologic ocular neovascularization. |
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| S8095 | Tubercidin | Tubercidin (7-deaza-adenosine), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhibits antifungal and antiviral activities. |
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| S0054 | D-I03 | D-I03 is a selective inhibitor of RAD52 with Kd of 25.8 µM. This compound inhibits ssDNA annealing by RAD52 and D-loop formation with IC50 of 5 µM and 8 µM, respectively. |
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| S5484 | Rimantadine Hydrochloride | Rimantadine is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. It works by inhibiting a viral protein called M2, which normally mediates the transport of acid ions across the influenza virion shell. |
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| S4504 | 6-Mercaptopurine (6-MP) Monohydrate | 6-Mercaptopurine (6-MP) Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. |
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| S7449 | CRT0044876 | CRT0044876 (NSC 69877, 7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM. |
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| S5293 | Nimustine Hydrochloride | Nimustine Hydrochloride (Nidran) is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death. |
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| S3549 | PFM01 | PFM01, a cell-permeable N-alkylated Mirin derivative, is a selective inhibitor of MRE11 endonuclease activity. |
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| S2600 | Fexinidazole | Fexinidazole (HOE-239, Fexinidazole Winthrop) is a 5-nitroimidazole derivative. This compound is a DNA synthesis inhibitor and the only, all-oral agent for Human African Trypanosomiasis(HAT or sleeping sickness). |
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| S9718 | TK216 |
TK216 is a potent inhibitor targeting E26 transformation specific (ETS) factors via blocking the protein-protein interaction with RNA helicases. This compound exhibits antilymphoma activity. |
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| S1790 | Rifaximin | Rifaximin is a RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria. |
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| S5552 | Amenamevir | Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent. |
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| S0280 | Madrasin | Madrasin (DDD00107587) is a potent and cell-penetrant pre-mRNA splicing inhibitor. This compound interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex. |
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| S9775 | SCR130 | SCR130 is a novel DNA repair inhibitor with IC50s of 14 μM in Reh cells and 2 μM in Nalm6 cells. This compound specifically inhibits DNA Ligase IV‐mediated joining with minimal or no effect on Ligase III and Ligase I mediated joining. |
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| E0488 | BC-LI-0186 | BC-LI-0186 is a selective blocker of Leucyl-tRNA synthetase (LRS, LeuRS) and Ras-related GTP-binding protein D (RagD) interaction (LRS-RagD interaction) (IC50 = 46.11 nM) by competing against RagD for LRS VC domain binding (KD = 42.1 nM), thereby inhibiting lysosomal localization of LRS and mTORC1 activity. This compound also effectively suppresses the activity of cancer-associated mTOR mutants and the growth of rapamycin-resistant cancer cells. |
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| S2961 | GC7 Sulfate | GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins. |
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| E4581 | Basic Orange 14 | Basic Orange 14(Acridine Orange hemi (zinc chloride) salt) acts as an inhibitor of RNA polymerase which also functions as a cell-permeable metachromatic fluorescent dye that stains DNA and RNA. | ||
| S3009 | Menthone |
Menthone is one of the main volatile components of the essential oil of peppermint (Mentha piperita L.). This compound is used as antioxidant agent and has a good compensatory effect with significant reduction in DNA damages in sperm cells. |
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| S3472 | Metarrestin | Metarrestin is an orally active and specific perinucleolar compartment (PNC) inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. This compound blocks metastatic development and extends survival in mouse cancer models. | ||
| S8376 | Rbin-1 | Rbin-1 (Ribozinoindole-1) is a potent chemical inhibitor of eukaryotic ribosome assembly. It inhibits recombinant full-length Mdn1's ATPase activity in vitro. | ||
| E1596 | AOH1996 | AOH1996 is an orally active small-molecule PCNA inhibitor with potential anti-tumor activity. It enhances the interaction between PCNA and RPB1, the largest subunit of RNA polymerase II. | ||
| S0816 | Brr2 Inhibitor C9 | Brr2 inhibitor C9 (Brr2 Inhibitor 9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa a group of progressive retinal degenerative disorders. | ||
| E8280New | Ecubectedin | Ecubectedin (PM14) is a transcriptional inhibitor that forms DNA adducts, blocking RNA synthesis and the transcription of protein-coding genes. It also exhibits potent antiproliferative activity in human solid cancer models both in vitro and in vivo. | ||
| E6712New | PYCR1-IN-1 | PYCR1-IN-1 (compound 4) is an inhibitor of pyrroline-5-carboxylate reductase 1 (PYCR1) with an IC50 of 8.8 µM. It significantly reduce the levels of proline within a breast cancer cell line and exhibits anti-cell proliferation effect. | ||
| S8328 | CeMMEC1 HCl | CeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (IC50=0.9 μM). | ||
| E5836 | ATX968 | ATX968 (DHX9-IN-2) is a potent, selective, and orally bioavailable inhibitor of DHX9 helicase with an IC50 of 8 nM. It induces strong and sustained tumor growth inhibition or regression in MSI-H/dMMR colorectal cancer (CRC) xenograft models. | ||
| E6402New | GSK4418959 | GSK4418959 (IDE275) is a non-covalent, reversible, selective, and orally bioavailable WRN helicase inhibitor. It exhibits ATP-competitive inhibition of both ATPase activity and DNA unwinding function. This compound serves as a research tool for investigating microsatellite instability-high (MSI-H) cancers. | ||
| S0063 | RG3039 | RG3039 (PF-06687859, PF 6687859, Quinazoline 495) is an orally bioavailable and brain-penetrant inhibitor of the mRNA decapping enzyme DcpS with IC50 of 4.2 nM and IC90 of 40 nM, respectively. | ||
| S0780 | Oncrasin-1 | Oncrasin-1 (Onc-1) is a potent RNA polymerase II inhibitor with antitumor activity that kills various human lung cancer cells with K-Ras mutations. This compound drives abnormal aggregation of protein kinase C iota (PKCι) in nucleus of sensitive cells but not in resistant cells. | ||
| S9286 | Neobavaisoflavone | Neobavaisoflavone, isolated from seeds of Psoralea corylifolia, exhibits inhibitory activity against DNA polymerase and platelet aggregation. | ||
| E0443 | LDC195943 (IMT1) | LDC195943 (IMT1) is a specific and noncompetitive inhibitor of human mitochondrial RNA polymerase (POLRMT). This compound causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. It reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases. | ||
| E0444 | LDC203974 (IMT1B) | LDC203974 (IMT1B) is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) that inhibits mitochondrial DNA (mtDNA) expression, and it has anti-tumour effects. | ||
| S7661New | Aphidicolin | Aphidicolin is a tetracyclic diterpenoid antibiotic produced by *Cephalosporium aphidicola* that specifically inhibits eukaryotic DNA polymerases α and δ, thereby blocking DNA replication and mitotic cell division. This compound demonstrates broad antiviral activity, including inhibition of herpes simplex virus replication and anti-orthopoxvirus effects. Additionally, this chemical enhances arabinosyl nucleoside-induced apoptosis in HL-60 human promyelocytic leukemia cells. | ||
| S9649 | Acelarin (NUC-1031) | Acelarin (NUC-1031, CPF-31, MTL-007, GTPL7389) is a DNA synthesis inhibitor with EC50 of 0.2 nM. | ||
| E1987 | APX2009 | APX2009 is a second-generation redox-specific inhibitor of APE1/Ref-1, an essential enzyme in the base excision repair (BER) pathway. This compound effectively reduces breast cancer cell proliferation and colony formation. | ||
| S0102 | L 189 | L 189 is a novel human DNA ligase inhibitor with IC50 of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively. This compound inhibits base excision repair (BER) and non-homologous end joining (NHEJ). It specifically sensitizes cancer cells to DNA damage. | ||
| S3641 | Osalmid | Osalmid suppresses ribonucleotide reductase (RNR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM. | ||
| S3360 | Bis(2-ethylhexyl) phthalate |
Bis(2-ethylhexyl) phthalate (Dioctyl phthalate, DOP, Diplast O, ESBO-D 82, Ergoplast FDO, Ergoplast FDO-S, Etalon) induces DNA strand breaks and gene expression alterations in larval zebrafish Danio rerio. |
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| S5297 | Vidarabine monohydrate | Vidarabine (Spongoadenosine, Vira-A) is a nucleoside antibiotic with antiviral acitivity that interferes with the synthesis of viral DNA. It is used to treat herpes simplex and varicella zoster viruses. | ||
| E7688 | L67 | L67 (DNA Ligase Inhibitor) is a competitive inhibitor of DNA ligase that effectively targets both DNA ligases I and III, with an IC50 of 10 μM for both enzymes. It specifically disrupts mitochondrial DNA metabolism in cancer cells. Inhibition of DNA ligase IIIα (LigIIIα) by this compound leads to significant alterations in mitochondrial morphology, reduces mitochondrial DNA levels, and increases reactive oxygen species (ROS). | ||
| S1126 | CX-3543(Quarfloxin) | CX-3543 (Quarfloxin), a fluoroquinolone derivative, inhibits RNA pol I activity by disrupting the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template. | ||
| S6115 | Pyridoxal 5′-phosphate hydrate | Pyridoxal 5′-phosphate (pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP), a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions. Pyridoxal 5′-phosphate at concentrations < 0.5 mM inhibits of polymerization deoxynucleoside triphosphate catalysed by variety of DNA polymerases isolated from type C RNA tumor viruses. The combination of Pyridoxal 5′-phosphate and NEIL2 will make NEIL2 completely lose its ability to bind damaged DNA. | ||
| E2921 | Diethyl Pyrocarbonate | Diethyl pyrocarbonate is a potent, non-specific inhibitor of RNase. It has been useful as an in vitro agent, relatively specific for binding to imidazole of histidine. It inhibits central chemosensitivity in rabbit and can modify Ser, Thr, His and Tyr residues. | ||
| S8977 | BCH001 | BCH001 is a specific PAPD5 inhibitor that restores telomerase activity and telomere length in dyskeratosis congenita (DC) patient induced pluripotent stem cells. This compound is a noncanonical poly(A) polymerase with an unusual RNA-binding motif. | ||
| E0510 | Cidofovir hydrate | Cidofovir hydrate is a selective inhibitor of viral DNA synthesis through the selective inhibition of viral DNA polymerase. | ||
| E6515New | ML-60218 | ML-60218 is a broad-spectrum inhibitor of RNA polymerase III (pol III), with an IC50 of 32 μM for Saccharomyces cerevisiae and 27 μM for human pol III. ML-60218 disrupts pre-assembled viroplasms and impedes the formation of new ones, acting independently of de novo transcription of cellular RNAs. | ||
| S4782 | 5-methoxyflavone | 5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. | ||
| E8200 | Epirubicin | Epirubicin (4'-epidoxorubicin) is a semisynthetic anthracycline derivative of doxorubicin that exerts its anti-tumor effect through binding to topoisomerase IIalpha (TOP2A) and inducing DNA double-strand breaks. It also acts as an inhibitor of Forkhead box protein p3 (Foxp3), reducing the immunosuppressive activity of regulatory T cells and enhancing anti-tumor immunity. | ||
| S4537 | Oxolinic acid | Oxolinic acid (Urinox, NSC 110364) is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor. | ||
| S8329 | CeMMEC13 | CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 µM). | ||
| E0511 | Framycetin sulphate | Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM, and competes for specific divalent metal ion binding sites in RNase P RNA, also inhibits hammerhead ribozyme with a Ki of 13.5 μM. | ||
| S7418 | Cycloheximide | Cycloheximide, an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. Cycloheximide suppresses ferroptosis and inhibits autophagy.Cycloheximide (NSC-185) can be used to induce animal models of Dysmnesia.Solutions are unstable and should be fresh-prepared.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
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| S1491 | Fludarabine | Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis. |
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| S1215 | Carboplatin | Carboplatin, a derivative of CDDP, is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death and interfers with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks. Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation. |
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| S8964 | Actinomycin D (Dactinomycin) | Actinomycin D (Dactinomycin, Act D, RASP-101) is a significant polypeptide antibiotic isolated from soil bacteria of the genus Streptomyces. Actinomycin D (Dactinomycin) inhibits DNA repair and rests the cell cycle at G1 phase with IC50 of 0.42 μM and 0.4 nM, respectively. Actinomycin D is an RNA and protein synthesis inhibitor that can suppress bacterial protein synthesis. Actinomycin D is an autophagy activator, induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
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| S8146 | Mitomycin C | Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
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| S8932 | GS-5734 (Remdesivir) | Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV. |
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| S1117 | Triciribine (API-2) | Triciribine (API-2) is a DNA synthesis inhibitor that also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; it does not inhibit PI3K/PDK1 and is 5000-fold less active in cells lacking adenosine kinase. Phase 1/2. |
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| S7409 | Anisomycin (Flagecidin) | Anisomycin (Flagecidin, Wuningmeisu C) is a bacterial antibiotic isolated from Streptomyces griseolus, which inhibits protein synthesis, and also act as a JNK activator. Anisomycin upregulates autophagy and increases apoptosis. |
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| S3035 | Daunorubicin Hydrochloride (Daunomycin) | Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.Daunorubicin (RP 13057) HCl can be used to induce animal models of Kidney Disease. |
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| S1135 | Pemetrexed Disodium (LY231514) | Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis. |
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| S2239 | Tubacin | Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. This compound reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis. |
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| S5971 | Pemetrexed | Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. This compound induces autophagy and apoptosis. |
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| S7419 | Blasticidin S Hydrochloride | Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes. It acts by blocking hydrolysis of peptidyl-tRNA induced by release factors and inhibits peptide bond formation. It is used to select transfected cells carrying bsr or BSD resistance genes. |
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| S1199 | Cladribine | Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively. |
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| S1373 | Daptomycin | Daptomycin is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. |
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| S1218 | Clofarabine | Clofarabine (Clolar) inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis. |
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| S8434 | RAD51 Inhibitor B02 | B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM). |
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| S1302 | Ifosfamide | Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer. |
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| S1807 | Acyclovir (Aciclovir) | Acyclovir (Aciclovir) is a synthetic nucleoside analogue active against herpesviruses, and it induces cell cycle perturbation and apoptosis in Jurkat leukemia cells. |
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| S1221 | Dacarbazine | Dacarbazine is a triazene derivative with antineoplastic activity. This compound alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis; it is used in the treatment of various cancers. |
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| S1192 | Raltitrexed | Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth. |
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| S1764 | Rifampin (Rifampicin) | Rifampin (Rifampicin) is a DNA-dependent RNA polymerase inhibitor and is used to treat a number of bacterial infections. |
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| S2678 | NSC 207895 | NSC 207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase. |
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| S1949 | Menadione (Vitamin K3) | A fat-soluble compound, Menadione (Vitamin K3) is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement. |
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| S1778 | Trifluridine (NSC 75520) | Trifluridine (NSC 75520), also known as NSC 529182, Viroptic, Trifluorothymidine, or TFT, is an anti-herpesvirus antiviral agent that acts by interfering with viral DNA replication and is used primarily on the eye. |
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| S5948 | Amodiaquine | Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria. |
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| S8539 | TAS-102 (Trifluridine/Tipiracil Hydrochloride Mixture) | TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride. |
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| S1907 | Metronidazole | Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa. |
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| S9936 | ART558 | ART558 is a potent, selective, low molecular weight, allosteric inhibitor of DNA Polθ with an IC50 of 7.9 nM. |
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| S9521 | Pentostatin | Pentostatin(CI-825,Deoxycoformycin) is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. |
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| S5953 | Menadione bisulfite sodium | Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement. |
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| E1528 | RP-6685 | RP-6685 is a potent, selective, and orally active inhibitor of DNA polymerase theta (Polθ). RP-6685 exhibits antitumor efficacy in animal models. |
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| S8942 | Suramin sodium salt | Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatase (PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp). |
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| S4737 | Psoralen | Psoralen (Psoralene, Ficusin, Furocoumarin) is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. |
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| S7637 | DTP3 | DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. This compound inhibits cancer-selective NF-κB survival pathway. |
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| S5813 | Isoginkgetin | Isoginkgetin is a naturally derived biflavonoid with anti-tumor activity. This compound directly inhibits the chymotrypsin-like, trypsin-like, and caspase-like activities of the 20S proteasome. It also is a general inhibitor of Pre-mRNA splicing. |
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| S3168 | cis-Resveratrol | cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively. |
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| S6848 | 3'-Fluoro-3'-deoxythymidine (Alovudine) | 3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. It is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer. |
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| S6854 | Triazavirin (TZV) | Triazavirin (TZV) is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. It is active against influenza and a number of other viruses, and is an effective protective agent on the transmission stage of influenza. |
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| E0459 | Robinetin | Robinetin inhibits HIV integrase cleavage and integration in a dose-dependent manne, inhibits the DNA synthesis in Proteus vulgaris, and the RNA synthesis in S. aureus, also inhibits egg yolk phosphatidylcholine (EYPC) membrane lipid peroxidation and hemoglobin A (HbA) glycosylation with high efficiency. | ||
| E1111 | VV116 | VV116, a promising orally administered anti-SARS-CoV-2 nucleoside drug candidate, exerts functions by targeting the viral RNA-dependent RNA polymerase through its nucleoside triphosphate form with an IC50 of 0.67±0.24 μM. | ||
| S3356 | Phosphonoacetic acid |
Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. This compound exhibits anti-viral activities. |
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| S0161 | ML367 | ML367 is a potent, micromolar inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization. This compound blocks DNA repair pathways and general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation. | ||
| E1529 | ART812 | ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. | ||
| S4236 | Proflavine Hemisulfate | Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands. | ||
| E6541New | PolQi2 | PolQi2 is a PolΘ inhibitor that specifically targets the N-terminal helicase domain of PolΘ, thereby suppressing alt-EJ (alternative end-joining) repair. This compound improves the accuracy and integration efficiency of gene editing across multiple loci and diverse cell lines. Additionally, PolQi2 demonstrates synergistic effects with DNA-PK inhibitors in reducing Cas9-mediated off-target activity. Its application is suitable for gene editing studies. | ||
| S2427 | Triglycidyl Isocyanurate (Teroxirone) | Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. This compound alkylates and cross-links DNA, thereby inhibiting DNA replication. It is also used in various polyester powder coatings in the metal finishing industry. | ||
| E1939 | ART899 | ART899, a derivative of ART558 is a potent, specific allosteric inhibitor of DNA polymerase theta (Polθ), specifically inhibits Polθ MMEJ activity with IC50 of 180 nM. It specifically radiosensitizes tumor cells and have a potent stand-alone antitumor effect in cancer cells. |
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