For research use only.

Catalog No.S1764 Synonyms: Rimactane,Rifampicin

7 publications

Rifampin Chemical Structure

Molecular Weight(MW): 822.94

Rifampin is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 90 In stock
USD 97 In stock
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Biological Activity

Description Rifampin is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.
RNA polymerase [1]
In vitro

Rifampin inhibits IκBα degradation and mitogen-activated protein kinase (MAPK) phosphorylation. Rifampin is found to bind to human MD-2 in a Rifampin and MD-2 concentration-dependent manner. Rifampin inhibits NF-κB activation induced by LPS (20 ng/ml) in a dose-dependent manner, with an IC50 of 44.1 μM in Blue hTLR4 293 cells (A) and immunocompetent microgial BV-2 cell. Rifampin (50 μM) suppresses NF-κB activation at varying LPS doses, and the maximum NF-κB level induced by LPS in the presence of Rifampin (50 μM) is much lower than that in the absence of Rifampin. Rifampin inhibits NO production induced by LPS (200 ng/ml) in a dose-dependent manner in BV-2 cells, with an IC50 of 21.2 μM. Rifampin suppresses LPS induced TNF-α and IL-1β production in both microglia BV-2 and RAW 264.7 macrophage cells. Rifampin-inhibiting innate immune signaling is independent of the pregnane X receptor NR1I2. [1] Rifampin combined with polyester vascular prostheses (PVP) functionalised with cyclodextrin (PVP-CD) results in significant bacterial adhesion reduction and growth inhibition against Gram-positive bacteria. [2] Rifampin (50 μg/mL) significantly reduces the CFU counts of stationary-phase cultures and reduces the CFU counts of the log-phase culture to zero. Rifampin is particularly suitable since it is bactericidal and starts killing M. tuberculosis within an hour of exposure. [3]


Solubility (25°C)

In vitro DMSO 100 mg/mL (121.51 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 822.94


CAS No. 13292-46-1
Storage powder
in solvent
Synonyms Rimactane,Rifampicin
Smiles COC1\C=C\OC2(C)OC3=C(C2=O)C4=C(O)C(=C(NC(=O)\C(=C\C=C\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C)C(=C4C(=C3C)O)O)\C=N\N5CCN(C)CC5

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04301310 Not yet recruiting Drug: BMS-986235 (Treatment A)|Drug: Rifampin (Treatment B) Healthy Participants Bristol-Myers Squibb May 15 2020 Phase 1
NCT04312282 Recruiting Drug: Tesetaxel|Drug: Itraconazole|Drug: Rifampin Advanced Solid Tumors Odonate Therapeutics Inc. March 6 2020 Phase 1
NCT04166669 Recruiting Drug: APX001|Drug: Itraconazole|Drug: Rifampin Fungal Infection Amplyx Pharmaceuticals November 12 2019 Phase 1
NCT03991312 Completed Drug: itraconazole|Drug: rifampin|Drug: mitapivat sulfate Healthy Volunteers Agios Pharmaceuticals Inc. June 20 2019 Phase 1
NCT03800381 Recruiting Other: Observational PK study Tuberculosis|Human Immunodeficiency Virus|Coinfection University of Florida|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) January 28 2019 --

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID