Phen-DC3 Trifluoromethanesulfonate

Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65 ± 6 and 50 ± 10 nM, respectively.

Phen-DC3 Trifluoromethanesulfonate Chemical Structure

Phen-DC3 Trifluoromethanesulfonate Chemical Structure

CAS: 929895-45-4

Purity & Quality Control

Batch: Purity: 99.86%
99.86

Phen-DC3 Trifluoromethanesulfonate Related Products

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Biological Activity

Description Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65 ± 6 and 50 ± 10 nM, respectively.
Targets
FANCJ [1] DinG [1]
65±6 nM 50±10 nM

Chemical Information & Solubility

Molecular Weight 848.75 Formula

C34H26N6O2.2CF3O3S

CAS No. 929895-45-4 SDF --
Smiles C[N+;v4]1=CC(=CC2=C1C=CC=C2)NC(=O)C3=NC4=C5N=C(C=CC5=CC=C4C=C3)C(=O)NC6=CC7=C(C=CC=C7)[N+;v4](=C6)C.O[S](=O)(=O)C(F)(F)F.[O-][S](=O)(=O)C(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (117.82 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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