Home DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor CeMMEC1 HCl

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CeMMEC1 HCl DNA/RNA Synthesis inhibitor

Cat.No.S8328

CeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (IC50=0.9 μM).
CeMMEC1 HCl DNA/RNA Synthesis inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 372.8

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S832801 DMSO]23 mg/mL]false]Ethanol]1 mg/mL]false]Water]Insoluble]false Purity: 99.74%
99.74

Chemical Information, Storage & Stability

Molecular Weight 372.8 Formula

C19H17ClN2O4

 Storage (From the date of receipt)
CAS No. 2095432-53-2 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CN1C=C(C2=CC=CC=C2C1=O)C(=O)NC3=CC4=C(C=C3)OCCO4.Cl

Solubility

In vitro
Batch:

DMSO : 23 mg/mL (61.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 1 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
TAF1 [1]
(Cell-based assay)
1.8 μM(Kd)
In vitro
CeMMEC1 only bound BRD4 very weakly but it shows high affinity for the bromodomains of CREBBP, EP300, BRD9 and the second bromodomain of TAF1[1].
References

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