Pyridoxal 5′-phosphate hydrate

Synonyms: pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP

Pyridoxal 5′-phosphate (pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP), a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions. Pyridoxal 5′-phosphate at concentrations < 0.5 mM inhibits of polymerization deoxynucleoside triphosphate catalysed by variety of DNA polymerases isolated from type C RNA tumor viruses. The combination of Pyridoxal 5′-phosphate and NEIL2 will make NEIL2 completely lose its ability to bind damaged DNA.

Pyridoxal 5′-phosphate hydrate Chemical Structure

Pyridoxal 5′-phosphate hydrate Chemical Structure

CAS: 853645-22-4

Purity & Quality Control

Batch: Purity: 99.05%
99.05

Pyridoxal 5′-phosphate hydrate Related Products

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Biological Activity

Description Pyridoxal 5′-phosphate (pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP), a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions. Pyridoxal 5′-phosphate at concentrations < 0.5 mM inhibits of polymerization deoxynucleoside triphosphate catalysed by variety of DNA polymerases isolated from type C RNA tumor viruses. The combination of Pyridoxal 5′-phosphate and NEIL2 will make NEIL2 completely lose its ability to bind damaged DNA.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06176482 Recruiting
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Azienda Ospedaliero Universitaria Pisana|Scuola Superiore Sant''Anna di Pisa
March 1 2023 Not Applicable
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Daiichi Sankyo Inc.|PXE International
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Chemical Information & Solubility

Molecular Weight 247.14 Formula

C8H10NO6P.xH2O

CAS No. 853645-22-4 SDF --
Smiles CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 49 mg/mL ( (198.26 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 6 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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