Pyridoxal 5′-phosphate hydrate

For research use only.

Catalog No.S6115 Synonyms: pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP

Pyridoxal 5′-phosphate hydrate Chemical Structure

CAS No. 853645-22-4

Pyridoxal 5′-phosphate (pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP), a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions. Pyridoxal 5′-phosphate at concentrations < 0.5 mM inhibits of polymerization deoxynucleoside triphosphate catalysed by variety of DNA polymerases isolated from type C RNA tumor viruses. The combination of Pyridoxal 5′-phosphate and NEIL2 will make NEIL2 completely lose its ability to bind damaged DNA.

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Biological Activity

Description Pyridoxal 5′-phosphate (pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP), a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions. Pyridoxal 5′-phosphate at concentrations < 0.5 mM inhibits of polymerization deoxynucleoside triphosphate catalysed by variety of DNA polymerases isolated from type C RNA tumor viruses. The combination of Pyridoxal 5′-phosphate and NEIL2 will make NEIL2 completely lose its ability to bind damaged DNA.

Protocol

References

Solubility (25°C)

Chemical Information

Molecular Weight 247.14
Formula

C8H10NO6P.xH2O

CAS No. 853645-22-4
Storage powder
in solvent
Synonyms pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP
Smiles CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05025722 Not yet recruiting Other: Non Interventional Pseudoxanthoma Elasticum Daiichi Sankyo Inc.|PXE International|Thomas Jefferson University August 2021 --
NCT04980248 Not yet recruiting Biological: ALXN1850 Hypophosphatasia Alexion Pharmaceuticals July 2021 Phase 1
NCT04672226 Not yet recruiting Dietary Supplement: PDE MAX Pyridoxine Dependant Epilepsy Vitaflo International Ltd|Radboud UMC|Great Ormond Street Hospital for Children NHS Foundation Trust June 1 2021 Not Applicable
NCT03783689 Active not recruiting Device: SPRINT Peripheral Nerve Stimulation (PNS) System Neuropathic Pain|Amputation SPR Therapeutics Inc. December 18 2018 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID