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DNA/RNA Synthesis Activators

Cat.No. Product Name Information Product Use Citations Product Validations
E5989New PZL-A PZL-A is a activator of mitochondrial DNA (mtDNA) synthesis. PZL-A restores wild-type-like activity to mutant forms of polymerase γ (POLγ) with 160 nM for A467T and 20 nM for G848S. In cellular systems, PZL-A stimulates mtDNA synthesis, promoting oxidative phosphorylation complex biogenesis and improving cellular respiration. PZL-A is promising agent for relieving POLG disease and other severe conditions linked to depletion of mtDNA.
S8326 Saccharin 1-methylimidazole (SMI) Saccharin 1-methylimidazole (SMI) is considered a general-purpose activator for DNA and RNA synthesis.
S6893 PIN1 inhibitor API-1 PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor with IC50 of 72.3 nM. This compound targets the Pin1 peptidyl-prolyl isomerase domain and inhibits its cis-trans isomerizing activity. It up-regulates miRNA biogenesis by retaining active XPO5 conformation and suppresses HCC development.
S4476 PCNA-I1 PCNA-I1 is a selective inhibitor of proliferating cell nuclear antigen (PCNA, a potential anticancer target). This compound selectively binds to PCNA trimers with Kd of ~0.2 to 0.4 μM. It inhibits the growth of tumor cells of various tissue types with IC50 of ~0.2 μM. This chemical induces DNA damage and apoptosis in both LNCaP and PC-3 cells. It also induces autophagy in PC-3 cells.
S4423 Emamectin Benzoate Emamectin Benzoate (EMB, MK-244) activates gamma-amino butyric acid (GABA) transporter. This compound induces of reactive oxygen species (ROS)-mediated DNA damage and apoptosis.
Viruses, 2025, 17(2)220