DNA/RNA Synthesis Chemicals

Cat.No.	Product Name	Information	Product Use Citations
S1237	TMZ(Temozolomide)	Temozolomide (TMZ) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. It is a DNA damage inducer in L-1210 and L-1210/BCNU cells. This compound induces apoptosis and exhibits antitumor activity.	Cancer Cell, 2025, S1535-6108(25)00223-5 Cancer Cell, 2025, 43(4):776-796.e14 Nat Commun, 2025, 16(1):5676
S1214	Bleomycin sulfate	Bleomycin sulfate is a glycopeptide antibiotic and a DNA synthesis inhibitor, as well as an anticancer agent for squamous cell carcinomas (SCC) with an IC50 of 4 nM in UT-SCC-19A cells. Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin (NSC125066) sulfate can be used to induce animal models of pulmonary fibrosis.	Nat Cell Biol, 2025, 10.1038/s41556-025-01648-3 Nat Commun, 2025, 16(1):1826 Nat Commun, 2025, 16(1):9183
S1212	Bendamustine HCl	Bendamustine HCl is a DNA-damaging agent with IC50 of 50 μM in cell-free assay.	Cancers (Basel), 2025, 17(11)1889 iScience, 2024, 27(10):110862 Res Sq, 2024, rs.3.rs-3848777
S3190	m6A (N6-methyladenosine)	m6A (N6-methyladenosine) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.	Nat Neurosci, 2025, 28(2):280-292 Nat Commun, 2025, 16(1):10378 Adv Sci (Weinh), 2024, 11(28):e2307981
S1840	Lomustine	Lomustine (NSC79037, Gleostine, CeeNU, CCNU) inhibits cancer cells by damaging the DNA and stops cells from dividing.	Neuro Oncol, 2025, noaf055 PLoS Pathog, 2024, 20(10):e1012601 iScience, 2024, 27(10):110862
S7918	BrdU (Bromodeoxyuridine, 5-BrdU)	BrdU (Bromodeoxyuridine) is a nucleoside analog that competes with thymidine for incorporation into DNA, and used in the detection of proliferating cells.	J Adv Res, 2025, S2090-1232(25)00961-0 FASEB J, 2025, 39(15):e70921 Free Radic Biol Med, 2024, 228:183-196
S4803	Thymidine	Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix.	J Clin Invest, 2025, 135(18)e193745 Journal of Clinical Investigation, 2025, e171047 Nat Commun, 2024, 15(1):2371
S2029	Uridine	Uridine (NSC 20256,β-Uridine, Uridin) is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.	EMBO Mol Med, 2025, 10.1038/s44321-025-00278-4 EMBO Molecular Medicine, 2025, 2258-2298 J Transl Med, 2025, 23(1):917
S4194	Azaguanine-8	Azaguanine-8 (NSC-749, SF-337, SK 1150) is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism.	J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 10.1007/s13577-021-00579-z
S1983	Adenine HCl	Adenine HCl(6-Aminopurine hydrochloride) is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.Adenine HCl can be used to induce animal models of Tubulointerstitial Fibrosis.	J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918
S1981	Adenine	Adenine(6-Aminopurine) is a purine derivative and a nucleobase with a variety of roles in biochemistry.This compound can be used to induce animal models of Tubulointerstitial Fibrosis.	PLoS Pathog, 2020, 16;16(3):e1008341
E7018	DNase I, Bovine pancreas	DNase I, Bovine pancreas is a Ca²⁺/Mg²⁺-dependent endonuclease that cleaves phosphodiester bonds double-stranded DNA, classified under EC 3.1.21.1 as a hydrolase. It binds to the minor groove of DNA, with key amino acids like R111, Y211, and N170 interacting with the DNA backbone to facilitate catalysis, while residues N74 and S206 in the active site are crucial for substrate binding and DNA recognition. DNase I is essential for DNA degradation, chromatin research, and is widely used to generate smaller DNA fragments for genomic studies and to examine DNA-protein interactions in chromatin remodeling research.
S4888	Guanine	Guanine is one of the four main nucleobases found in the nucleic acids DNA and RNA.
S5505	2’-deoxyuridine	2'-deoxyuridine (dU, 2'-dU) is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms.
S6359	Purine	Purine is a heterocyclic aromatic organic compound which plays crucial roles in DNA and RNA. It is also significant components in a number of other important biomolecules, such as ATP, GTP, cyclic AMP, NADH, and coenzyme A.
E1255	5-Ethynyluridine	5-Ethynyluridine (5-EU) is a cell-permeable nucleoside and can be used to label newly synthesized RNA.
S1982	Adenine sulfate	Adenine sulfate(Adenine hemisulfate) is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.Adenine sulfate can be used to induce animal models of Tubulointerstitial Fibrosis.
S6077	Cytidine 5′-triphosphate (disodium salt)	Cytidine 5'-triphosphate is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases.
E8010^New	Methylproamine	Methylproamine functions as a DNA-binding radioprotective agent that mitigates radiation damage through repair of transient oxidative species on DNA. Additionally, it provides protection against ionizing radiation by inhibiting DNA double-strand breaks.
E8190	L-Asparaginase	L-Asparaginase(L-ASNase) is a deamidating enzyme that hydrolyzes L-asparagine and L-glutamine, depleting L-asparagine in the blood and bone marrow. It exhibits anti-leukemic effects by inhibiting RNA and DNA synthesis, leading to blastic cell apoptosis, and is used in acute lymphoblastic leukemia (ALL) research and treatment.
S5374	5'-Cytidylic acid	5'-Cytidylic acid (Cytidine monophosphate, Cytidine 5'-phosphate) is a nucleotide that is used as a monomer in RNA.
S5384	UTP Trisodium Salt	Uridine-5'-triphosphate (UTP) is a pyrimidine nucleoside triphosphate and a substrate for the synthesis of RNA during transcription.
S9382	Thymine	Thymine (5-methyluracil) is one of the four nucleobases in the nucleic acid of DNA.
E6580^New	Nusinersen	Nusinersen is an 18-mer, 2′-O-(2-methoxyethyl) phosphorothioate antisense oligonucleotide used for treating spinal muscular atrophy (SMA). It binds specifically to the intronic splice silencer N1 (ISS-N1) site in intron 7 of SMN2 pre-mRNA, blocking the binding of splicing repressors hnRNP A1/A2. This promotes inclusion of exon 7 during splicing, restoring full-length SMN protein production in SMA patients.