Remdesivir (GS-5734)

For research use only.

Catalog No.S8932

10 publications

Remdesivir (GS-5734) Chemical Structure

CAS No. 1809249-37-3

Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.

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10mM (1mL in DMSO) USD 970 In stock
USD 227 In stock
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Selleck's Remdesivir (GS-5734) has been cited by 10 publications

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Biological Activity

Description Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.
In vitro

GS-5734 exhibits antiviral activity against multiple variants of EBOV in cell-based assays(EC50=0.06-0.14 μM) and broad-spectrum antiviral activity in vitro against other pathogenic RNA viruses. [1]GS-5734 acts as a broad-spectrum therapeutic to protect against CoVs with EC50 of 0.03 μM for murine hepatitis virus in delayed brain tumor cells and 0.074 μM for SARS-CoV and MERS-CoV in HAE cells.[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Hep2 MlzrRY51cX[rcnHsJIFkfGm4aYT5JIF{e2G7 M1K4SlQh\GG7cx?= NFfPbWJGSzVyIE2gNE4xOTVizszN NGjnNHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEGyOFkxPyd-MkixNlQ6ODd:L3G+
TERT-immortalized HMVEC MVTBcpRqfmm{YXygZYN1cX[rdImgZZN{[Xl? MoXhN{B1dyB2IHThfZM> NWjS[ZRvTUN3MDC9JFAvODV|IN88US=> NWT5N2d[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixNlQ6ODdpPkK4NVI1QTB5PD;hQi=>
HuH7 NH7ke|dCdnSrdnnyZYwh[WO2aY\peJkh[XO|YYm= MXSzJIRigXN? NGGwbmZGSzVyIE2gNE4xPTdizszN NXi1ZmVlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixNlQ6ODdpPkK4NVI1QTB5PD;hQi=>
HuH7 NUe3Wnl5SW62aY\pdoFtKGGldHn2bZR6KGG|c3H5 MXmzJIRigXN? MYfFR|UxKD1iMD6wO{DPxE1? NF;4SHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEe5Nlc3Oyd-Mki3PVI4PjN:L3G+
macrophages MWPBcpRqfmm{YXygZYN1cX[rdImgZZN{[Xl? Mnr2OFghcA>? MYjFR|UxKD1iMD6wPFYh|ryP M3vtfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUK0PVA4Lz5{OEGyOFkxPzxxYU6=
macrophages MVXBcpRqfmm{YXygZYN1cX[rdImgZZN{[Xl? MoTBOFghcA>? NVzxXHFWTUN3MDC9JFAvODh4IN88US=> NH7INII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEe5Nlc3Oyd-Mki3PVI4PjN:L3G+
HeLa M3[1bWFvfGm4aYLhcEBi[3Srdnn0fUBie3OjeR?= MVO0PEBp M{fYPWVEPTBiPTCwMlEh|ryP MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF{NEmwO{c,OjhzMkS5NFc9N2F-
HeLa MmnERY51cX[rcnHsJIFkfGm4aYT5JIF{e2G7 M13QblQ5KGh? NXPKOIYzTUN3MDC9JFAvOTRizszN NXHNVWJrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3PVI4PjNpPkK4O|kzPzZ|PD;hQi=>
MT4 NEDjWYREgXSxdH;4bYNqfHliYYPzZZk> M4TYelQhfG9iNTDkZZl{ M4\Ye2NEPTBiPTCxMlch|ryP NUTzXG1DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixNlQ6ODdpPkK4NVI1QTB5PD;hQi=>
Hep2 M1;BVmN6fG:2b4jpZ4l1gSCjc4PhfS=> NHHSOXE1KHSxIEWg[IF6ew>? MnHER2M2OCB;IE[uNUDPxE1? NFnMT449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEGyOFkxPyd-MkixNlQ6ODd:L3G+
HuH7 NGPLZmVEgXSxdH;4bYNqfHliYYPzZZk> MX[zJIRigXN? MV7DR|UxKD1iM{[g{txO M4jtb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUK0PVA4Lz5{OEGyOFkxPzxxYU6=

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In vivo

Regardless of the time of initiation, GS-5734 treatment confers improved survival when administered by 3 mg/kg GS-5734. All animals in which 10 mg/kg GS-5734 treatments is initiated 3 days after virus exposure survive to the end of the in-life phase. However, the antiviral effects are consistently greater in animals administered repeated 10 mg/kg GS-5734 doses. The 10 mg/kg D3 (administered beginning 3 days after virus exposure) GS-5734 regimen is associated with amelioration of EVD-related clinical disease signs and markers of coagulopathy and end organ pathophysiology.[1]

Protocol

Animal Research:

[1]

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  • Animal Models: Rhesus monkeys (Macaca mulatta)
  • Dosages: 3 mg / kg, 10 mg / kg
  • Administration: IV
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (165.95 mM)
Water Insoluble
Ethanol '''16 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 602.58
Formula

C27H35N6O8P

CAS No. 1809249-37-3
Storage powder
in solvent
Synonyms N/A
Smiles CCC(CC)COC(=O)C(C)NP(=O)(OCC1C(C(C(O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID