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DNA/RNA Synthesis Modulators

Cat.No. Product Name Information Product Use Citations Product Validations
S9603 Lurbinectedin (PM01183) Lurbinectedin, a DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity. Lurbinectedin inhibits RMG1 and RMG2 cell growth with IC50 of 1.25 nM and 1.16 nM, respectively.
Cancers, 2025, 2930
Cancers (Basel), 2025, 17(17)2930
STAR Protoc, 2025, 6(2):103767
S6909 Levomefolic acid Levomefolic acid (5-MTHF, LMSR, Metafolin, Nutrifolin) is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.
S6997 CHAPS CHAPS is a zwitterionic surfactant that decreases the sequence specificity of the nucleosome.
E7434 Illudin S Illudin S is a potent antitumor sesquiterpene metabolically activated into reactive intermediates that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC50 = 6-11 nM). It was first isolated from the fungus Clitocybe illudens and disrupts thymidine-dependent DNA synthesis without affecting RNA or protein synthesis.
S9716 H3B-8800 H3B-8800 is a potent and orally active modulator of SF3B splicing. H3B-8800 interacts directly with the SF3b complex, demonstrating anti-cancer properties. H3B-8800 holds promise for studying acute myeloid leukemia (AML) with SF3B1 mutations.