Home Cell Cycle DNA/RNA Synthesis inhibitor - eIF inhibitor - p21 inhibitor GC7 Sulfate

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GC7 Sulfate DNA/RNA Synthesis inhibitor

Cat.No.S2961

GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.
GC7 Sulfate DNA/RNA Synthesis inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 270.35

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Quality Control

Chemical Information, Storage & Stability

Molecular Weight 270.35 Formula

C8H22N4O4S

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 150417-90-6 -- Storage of Stock Solutions

Synonyms N1-guanyl-1,7-diaminoheptane Sulfate Smiles NCCCCCCCNC(N)=N.O[S](O)(=O)=O

Solubility

In vitro
Batch:

Water : 5 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
DHPS [1]
p21 [1]
In vitro

GC7 Sulfate, a deoxyhypusine synthase (DHPS) inhibitor, inhibits MYCN-amplified and chemotherapy-resistant NB cell proliferation, regulates several cell cycle controlling proteins and triggers arrest via the p21/Cdk4/Rb signaling axis, even in the presence of MYCN.[1]
References

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