Home Apoptosis p53 activator - DNA/RNA Synthesis inhibitor Triglycidyl Isocyanurate (Teroxirone)

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Triglycidyl Isocyanurate (Teroxirone) p53 activator

Cat.No.S2427

Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. This compound alkylates and cross-links DNA, thereby inhibiting DNA replication. It is also used in various polyester powder coatings in the metal finishing industry.
Triglycidyl Isocyanurate (Teroxirone) p53 activator Chemical Structure

Chemical Structure

Molecular Weight: 297.26

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S242701 DMSO]59 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.52%
99.52

Chemical Information, Storage & Stability

Molecular Weight 297.26 Formula

C12H15N3O6

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 2451-62-9 -- Storage of Stock Solutions

Synonyms Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC Smiles C1C(O1)CN2C(=O)N(C(=O)N(C2=O)CC3CO3)CC4CO4

Solubility

In vitro
Batch:

DMSO : 59 mg/mL (198.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
p53 [1]
DNA synthesis [1]
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06374173 Recruiting
Advanced or Metastatic Solid Tumors
Hefei TG ImmunoPharma Co. Ltd.
 January 3 2024 Phase 1

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