Triglycidyl Isocyanurate (Teroxirone)

Catalog No.S2427 Synonyms: Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC

For research use only.

Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.

Triglycidyl Isocyanurate (Teroxirone) Chemical Structure

CAS No. 2451-62-9

Purity & Quality Control

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Biological Activity

Description Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.
Targets
p53 [1]
()
DNA synthesis [1]
()

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 59 mg/mL
(198.47 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 297.26
Formula

C12H15N3O6

CAS No. 2451-62-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C(O1)CN2C(=O)N(C(=O)N(C2=O)CC3CO3)CC4CO4

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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