3'-Fluoro-3'-deoxythymidine (Alovudine)

Catalog No.S6848 Synonyms: CL 184824, FddThd, FLT, MIV-310

For research use only.

3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.

3'-Fluoro-3'-deoxythymidine (Alovudine) Chemical Structure

CAS No. 25526-93-6

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Biological Activity

Description 3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.
Targets
polymerase γ [3] Reverse transcriptase [2]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 244.22
Formula

C10H13FN2O4

CAS No. 25526-93-6
Storage 3 years -20°C(in the dark) powder
2 years -80°C(in the dark) in solvent
Smiles CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)F

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05383014 Not yet recruiting -- Acute Myeloid Leukemia Assiut University June 1 2022 --
NCT05445011 Recruiting Drug: Fludarabine + Cyclophosphamide + TAA05 Cell Injection Acute Myeloid Leukemia Wuhan Union Hospital China|PersonGen BioTherapeutics (Suzhou) Co. Ltd. June 14 2022 Phase 1
NCT03633955 Not yet recruiting Drug: FLT Acute Lymphocytic Leukemia|Acute Myeloid Leukemia|Ambiguous Lineage Leukemia or Lymphoma|Myelodysplastic Syndrome University of Oklahoma|Emory University May 2022 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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