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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S7099 (-)-Blebbistatin (-)-Blebbistatin ((S)-(-)-Blebbistatin) is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM in cell-free assays, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly.
Nat Commun, 2025, 16(1):9578
Nat Commun, 2025, 16(1):1012
Cell Biosci, 2025, 15(1):146
Verified customer review of (-)-Blebbistatin
S7895 Thapsigargin Thapsigargin is a potent, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50 of 0.353 nM or 0.448 nM for the carbachol-evoked [Ca2+]i-transients with or without a KCl-prestimulation. Thapsigargin induces cell apoptosis. Thapsigargin is extracted from a plant, Thapsia garganica.
EMBO J, 2025, 44(4):1107-1130
Proc Natl Acad Sci U S A, 2025, 122(20):e2502652122
Cell Death Dis, 2025, 16(1):289
S1413 Bafilomycin A1 (Baf-A1) Bafilomycin A1 (Baf-A1) is a vacuolar H+-ATPase inhibitor with IC50 of 0.44 nM, and it is found to inhibit autophagy while inducing apoptosis.
Nature, 2025, 10.1038/s41586-025-09745-x
Cell Res, 2025, 10.1038/s41422-025-01085-9
Signal Transduct Target Ther, 2025, 10(1):81
Verified customer review of Bafilomycin A1 (Baf-A1)
S1478 Oligomycin A (MCH 32) Oligomycin A (MCH 32), a dominant analog of the isomers, is an inhibitor of mitochondrial F1FO ATP synthase which inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria. It inhibits ATP synthase by blocking its proton channel (Fo subunit), which is necessary for oxidative phosphorylation of ADP to ATP. It also induces apoptosis in a variety of cell types.
Nat Commun, 2025, 16(1):212
Int J Biol Sci, 2025, 21(1):233-250
Cell Rep, 2025, 44(7):115973
Verified customer review of Oligomycin A (MCH 32)
S1238 Tamoxifen Tamoxifen is an orally active, selective estrogen receptor modulator (SERM) which exhibits both estrogenic agonist and antagonist effects. It blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity.
Cell Discov, 2025, 11(1):89
Nat Genet, 2025, 57(9):2192-2202
Cell Metab, 2025, 37(8):1715-1731.e11
Verified customer review of Tamoxifen
S2623 Omecamtiv mecarbil (CK-1827452) Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure, currently in Phase 2.
Nat Biotechnol, 2025, 10.1038/s41587-025-02725-6
Eur Heart J, 2025, ehaf813
Acta Neuropathol, 2024, 147(1):72
Verified customer review of Omecamtiv mecarbil (CK-1827452)
S7046 Brefeldin A (BFA) Brefeldin A (BFA) is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.
Protein Cell, 2025, pwaf020
Cancer Commun (Lond), 2025, 10.1002/cac2.70036
J Integr Plant Biol, 2025, 67(8):2229-2244
Verified customer review of Brefeldin A (BFA)
S8101 CB-5083 CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor with IC50 of 11 nM. Phase 1.
Nat Commun, 2025, 16(1):3546
EMBO J, 2025, 10.1038/s44318-025-00517-x
Proc Natl Acad Sci U S A, 2025, 122(27):e2426218122
Verified customer review of CB-5083
S4290 Digoxin Digoxin is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
J Exp Clin Cancer Res, 2025, 44(1):294
Pharmaceuticals (Basel), 2025, 18(2)181
Drug Metab Dispos, 2025, 53(4):100049
S2000 Sodium orthovanadate Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM.
Cancer Gene Ther, 2025, 10.1038/s41417-025-00874-z
Cell Death Dis, 2022, 13(6):524
Toxicol Appl Pharmacol, 2022, 441:115988

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