Pantoprazole sodium

For research use only.

Catalog No.S4538 Synonyms: SKF96022 sodium, BY-1023 sodium

1 publication

Pantoprazole sodium Chemical Structure

CAS No. 138786-67-1

Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.

Selleck's Pantoprazole sodium has been cited by 1 publication

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Biological Activity

Description Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.
Targets
Proton pump [4]
()
HIF-1α [2]
()
(H+/K+)-ATPase [4]
()
In vitro

pantoprazole (PPZ) inhibits tumor cells proliferation, inducs apoptosis and decreases the expression of HIF-1α protein[2]. Pantoprazole affects the intracellular distribution of HIF-1α in SGC-7901 cells, which might be one of the mechanisms of its chemosensitizing effect on cancer cells[3].

In vivo After PPZ treatment, apoptotic cell death is seen selectively in cancer cells and is accompanied with extracellular signal-regulated kinase deactivation. By contrast, normal gastric mucosal cells show the resistance to PPZ-induced apoptosis through the overexpression of antiapoptotic regulators including HSP70 and HSP27. In a xenograft model of nude mice, administration of PPZ significantly inhibits tumorigenesis and induces large-scale apoptosis of tumor cells[4].

Protocol

Cell Research:

[1]

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  • Cell lines: SGC-7901 cell line
  • Concentrations: 20 μg/ml
  • Incubation Time: 24 h
  • Method:

    Pantoprazole sodium salts are resuspended in normal saline (0.85%) at 5 mg/ml immediately prior to use. When the SGC-7901 cells have reached 60–70% confluence, PPZ is added at a final concentration of 20 µg/ml, and the cells are cultured for additional experiments. For example, The SGC-7901 cells are seeded in 100 µl of medium per well, at a density of 1×104/well, in 96-well plates and treated with PPZ for 24 h.


    (Only for Reference)
Animal Research:

[4]

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  • Animal Models: Mice inoculated with MKN-45 cells (Xenograft Model of Nude Mice)
  • Dosages: 0.4 mg/kg 
  • Administration: intratumor injection 
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 81 mg/mL (199.82 mM)
Water 81 mg/mL (199.82 mM)
Ethanol 81 mg/mL (199.82 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 405.35
Formula

C16H14F2N3NaO4S

CAS No. 138786-67-1
Storage powder
in solvent
Synonyms SKF96022 sodium, BY-1023 sodium
Smiles COC1=C(C(=NC=C1)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F)OC.[Na+]

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID