For research use only.

Catalog No.S2105 Synonyms: SKFSKF96022, BY-1023

2 publications

Pantoprazole  Chemical Structure

CAS No. 102625-70-7

Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.

Selleck's Pantoprazole has been cited by 2 publications

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Biological Activity

Description Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.
(H+/K+)-ATPase [1]
Proton pump [1]
In vitro

PPZ(Pantoprazole) inhibits the proliferation of tumor cells, induces apoptosis and downregulates the expression of PKM2, which contributes to the current understanding of the functional association between PPZ and PKM2(The human M2 isoform of pyruvate kinase)[2]. Ex vivo studies showed that pantoprazole inhibited TOPK activities in JB6 Cl41 cells and HCT 116 colorectal cancer cells. Moreover, knockdown of TOPK in HCT 116 cells decreased their sensitivities to pantoprazole[3].

In vivo i.p. injection of pantoprazole in HCT 116 colon tumor-bearing mice effectively suppresses cancer growth. The TOPK downstream signaling molecule phospho-histone H3 in tumor tissues is also decreased after pantoprazole treatment[3]. At higher infusion rates, pantoprazole is able to induce negative hemodynamic responses, in particular, in the setting of heart failure. These effects can lead to significant impairment of cardiac function[4]. Also, pantoprazole delays fracture healing by affecting both bone formation and bone remodeling[5].


Cell Research:


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  • Cell lines: SGC-7901 cells
  • Concentrations: 5 mg/ml
  • Incubation Time: 24 h
  • Method:

    The SGC-7901 cells are seeded in 100 µl of medium per well, at a density of 1x104/well, in 96-well plates and treated with 5 mg/ml PPZ for 24 h. The cytotoxicity of PPZ is assessed by a cell counting kit-8 assay. The cytotoxicity is expressed as the relative cell viability, using the following formula: Cell viability (%) = (OD of drug-treated sample/OD of untreated sample) x 100. The experiment is repeated 3 times.

    (Only for Reference)
Animal Research:


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  • Animal Models: Non-obese Diabetic/Severe Combined Immunodeficiency (NOD-SCID) mice
  • Dosages: 100 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 76 mg/mL (198.24 mM)
Ethanol 76 mg/mL (198.24 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 383.37


CAS No. 102625-70-7
Storage powder
in solvent
Synonyms SKFSKF96022, BY-1023
Smiles COC1=C(C(=NC=C1)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC(F)F)OC

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04248335 Recruiting Drug: Pantoprazole|Drug: Midazolam injection Pediatric Obesity|NAFLD|GERD Children''s Mercy Hospital Kansas City July 3 2018 Phase 4
NCT02401035 Recruiting Drug: IV pantoprazole Gastroesophageal Reflux Disease Pfizer May 9 2017 Phase 4
NCT02274961 Unknown status Drug: S-pantoprazole 10mg|Drug: Placebo Non Erosive Reflux Disease Ahn-Gook Pharmaceuticals Co.Ltd October 2014 Phase 3
NCT02186652 Completed Drug: Pantoprazole Gastroesophageal Reflux Disease Phillip Brian Smith|The Emmes Company LLC|Duke University June 4 2014 Phase 1
NCT01710462 Withdrawn Drug: Pantoprazole + Domperidone|Drug: Pantozol® Gastroesophageal Reflux Disease Eurofarma Laboratorios S.A. August 2013 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID