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Catalog No.S4099 Synonyms: T 168390,TAK 390

1 publication

Dexlansoprazole Chemical Structure

Molecular Weight(MW): 369.36

Dexlansoprazole, the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties.

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Selleck's Dexlansoprazole has been cited by 1 publication

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Description Dexlansoprazole, the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties.
Features A modified release formulation of an enantiomer of lansoprazole.
Proton pump [1]
In vitro

Dexlansoprazole, constitutes >80% of circulating drug after oral administration of lansoprazole, provides lower clearance and 5-fold greater systemic exposure than the S-enantiomer following oral administration of lansoprazole. Dexlansoprazole MR is a modified release formulation of dexlansoprazole, which employs a novel Dual Delayed Release (DDR) technology that delivers the drug in two discrete phases of release, thereby inhibiting newly activated proton pumps that turn over following initial PPI inactivation of H+,K+-ATPase. Dexlansoprazole MR maintains plasma drug concentrations above the threshold level longer than lansoprazole at all doses, resulting in an optimized drug exposure-intragastric pH relationship. [1] Dexlansoprazole selectively suppresses gastric acid secretion by direct inhibition of the H+K+-ATPase proton pump in the gastric parietal cell, inhibition of this cell membrane enzyme ultimately blocks the final step in acid production. [2]


Solubility (25°C)

In vitro DMSO 74 mg/mL (200.34 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 369.36


CAS No. 138530-94-6
Storage powder
in solvent
Synonyms T 168390,TAK 390
Smiles CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02442752 Withdrawn Drug: Dexlansoprazole Pediatric Gastroesophageal Reflux Disease Takeda June 15 2025 Phase 1
NCT03316976 Completed Drug: Dexlansoprazole Healthy Volunteers Takeda November 22 2017 Phase 1
NCT03079050 Completed Drug: Dexlansoprazole 60 MG GERD|Proton Pump Inhibitor American University of Beirut Medical Center|Takeda February 27 2017 Phase 4

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID