Esomeprazole sodium

Catalog No.S2233

For research use only.

Esomeprazole Sodium is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg.

Esomeprazole sodium Chemical Structure

CAS No. 161796-78-7

Selleck's Esomeprazole sodium has been cited by 6 Publications

Purity & Quality Control

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Biological Activity

Description Esomeprazole Sodium is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg.
ATPase [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 73 mg/mL
(198.69 mM)
Water 73 mg/mL
(198.69 mM)
Ethanol 73 mg/mL
(198.69 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 367.4


CAS No. 161796-78-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=C(C=C3)OC.[Na+]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05062876 Recruiting Drug: AD-214|Drug: AD-2141 Gastroesophageal Reflux Disease Addpharma Inc. November 3 2021 Phase 1
NCT05061563 Completed Drug: Elinzanetant (BAY3427080)|Drug: Esomeprazole Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men|Hot Flashes Bayer September 30 2021 Phase 1
NCT04494243 Completed Drug: AD-214 10/600mg|Drug: Rabeprazole 10mg Gastroesophageal Reflux Disease Addpharma Inc. August 28 2020 Phase 1
NCT04156646 Completed Drug: Balovaptan|Drug: Esomeprazole Autism Spectrum Disorder Hoffmann-La Roche November 19 2019 Phase 1
NCT03372850 Unknown status Drug: HIP1601|Drug: HGP1705 Healthy Hanmi Pharmaceutical Company Limited February 15 2018 Phase 1

(data from, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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