Golgicide A

For research use only.

Catalog No.S7266

8 publications

Golgicide A Chemical Structure

CAS No. 1139889-93-2

Golgicide A is a potent and rapidly reversible GBF1 inhibitor.

Selleck's Golgicide A has been cited by 8 publications

1 Customer Review

  • CSFV multiplication was inhibited by GCA. (A) The safe concentration of GCA was tested using the MTT assay. The operations and calculations were the same as those used for BFA. (B) Cellular CSFV RNA with or without 400 nM GCA were examined using real-time PCR. (C) The titers of CSFV with or without GCA were tested by IFA. (D) CSFV proliferation in ST cells with or without GCA was observed by IFA at 24, 48 and 72 hpi. Results from the three independent experiments are shown as means ± SD. *P<0.05 and **P<0.01 compared with the control group.

    J Biosci, 2017, 42(1):43-56. Golgicide A purchased from Selleck.

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Biological Activity

Description Golgicide A is a potent and rapidly reversible GBF1 inhibitor.
GBF1 [1]
In vitro

Golgicide A inhibits the effect of shiga toxin on protein synthesis with an IC50 of 3.3 μM. Golgicide A causes a decrease in GBF1-mediated Arf1 activation, arrests secretion of soluble and membrane-anchored proteins and then impairs retrograde toxin transport. [1] Golgicide A decreases HCV RNA levels in FLRP1 cells and J6/JFH1 cells. In addition, Golgicide A causes redistribution of NS5A and accumulation of infectious viral particles in J6/JFH1 cells. [2]


Solubility (25°C)

In vitro DMSO 57 mg/mL (200.49 mM)
Ethanol 4 mg/mL (14.06 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 284.3


CAS No. 1139889-93-2
Storage powder
in solvent
Synonyms N/A
Smiles C1C=CC2C1C(NC3=C2C=C(C=C3F)F)C4=CN=CC=C4

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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