Home Transmembrane Transporters ATPase inhibitor Golgicide A For research use only.

Golgicide A

Golgicide A is a potent and rapidly reversible GBF1 inhibitor.

Golgicide A Chemical Structure

Golgicide A Chemical Structure

CAS: 1139889-93-2

Selleck's Golgicide A has been cited by 9 Publications

1 Customer Review

Purity & Quality Control

Batch: S726601 DMSO] 57 mg/mL] false] Ethanol] 4 mg/mL] false] Water] Insoluble] false Purity: 99.35%
99.35

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Biological Activity

Description Golgicide A is a potent and rapidly reversible GBF1 inhibitor.
Targets
GBF1 [1]
In vitro
In vitro Golgicide A inhibits the effect of shiga toxin on protein synthesis with an IC50 of 3.3 μM. Golgicide A causes a decrease in GBF1-mediated Arf1 activation, arrests secretion of soluble and membrane-anchored proteins and then impairs retrograde toxin transport. [1] Golgicide A decreases HCV RNA levels in FLRP1 cells and J6/JFH1 cells. In addition, Golgicide A causes redistribution of NS5A and accumulation of infectious viral particles in J6/JFH1 cells. [2]

Chemical Information & Solubility

Molecular Weight 284.3 Formula

C17H14F2N2
CAS No. 1139889-93-2 SDF Download Golgicide A SDF
Smiles C1C=CC2C1C(NC3=C2C=C(C=C3F)F)C4=CN=CC=C4
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 57 mg/mL ( (200.49 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 4 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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