For research use only.

Catalog No.S1354 Synonyms: A-65006, AG-1749

1 publication

Lansoprazole Chemical Structure

Molecular Weight(MW): 369.36

Lansoprazole (A-65006, AG-1749) is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.

Size Price Stock Quantity  
10mM (1mL in DMSO) RMB 466.83 In stock
RMB 792.36 In stock
RMB 1627.14 In stock
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Selleck's Lansoprazole has been cited by 1 publication

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Biological Activity

Description Lansoprazole (A-65006, AG-1749) is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.
Proton pump [1]
In vitro

Lansoprazole inhibits gastric acid secretion via inhibition of gastric hydrogen/potassium adenosine triphosphatase (H+,K(+)-ATPase), an enzyme of the gastric parietal cell membrane that forms part of the proton pump that performs the final step in the acid secretory process. Lansoprazole binds covalently to parietal cell H+,K(+)-ATPase, rendering it nonfunctional and inhibiting the secretion of gastric acid. [1] Lansoprazole is a strong anti-secretory agent that acts on gastric H+/K+-adenosine triphosphatase (H+/K+ ATPase) of parietal cells. Lansoprazole inhibits the increased expression of vascular adhesion molecules, the activation of neutrophils, and the production of pro-inflammatory cytokines from activated endothelial cells. Lansoprazole induces several genes, including phase II detoxifying enzyme (NADPH-ubiquinone oxidoreductase, glutathione S-transferase) and antioxidant stress proteins (HO-1, thioredoxin reductase, and superoxide dismutase) in gastric epithelial cells. Lansoprazole significantly inhibits the production of CINC-1 from stimulated RGM-1 cells with IL-1β. Lansoprazole up-regulates HO-1 expression throughout Nrf2 in rat gastric epithelial cells, and the up-regulated HO-1 has anti-inflammatory effects. [2]

In vivo Lansoprazole inhibits acute inflammatory reactions as well as intestinal mucosal injuries induced by ischemia-reperfusion or indomethacin administration in rats. Lansoprazole significantly inhibits intestinal injuries induced by ischemia-reperfusion or indomethacin. lansoprazole administered exogenously prevents the small intestine against ischemia-reperfusion or indomethacin-induced damage, the action being dependent on its anti-inflammatory and anti-oxidative responses. [2]


Solubility (25°C)

In vitro DMSO 74 mg/mL (200.34 mM)
Water Insoluble
Ethanol '14 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 369.36


CAS No. 103577-45-3
Storage powder
in solvent
Synonyms A-65006, AG-1749
Smiles CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02442752 Withdrawn Drug: Dexlansoprazole Pediatric Gastroesophageal Reflux Disease Takeda June 15 2025 Phase 1
NCT03316976 Completed Drug: Dexlansoprazole Healthy Volunteers Takeda November 22 2017 Phase 1

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Proton Pump Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID