For research use only.

Catalog No.S7460

1 publication

BTB06584 Chemical Structure

Molecular Weight(MW): 417.82

BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase.

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Selleck's BTB06584 has been cited by 1 publication

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  • Changes of mitochondrial membrane potential (ΔΨm). (A) Representative micrographs captured by confocal laser scanning microscope were evaluated for ΔΨm by staining with JC-1 at 24h post ionizing radiation. Red dimers indicated normal mitochondrial function and green monomers indicated collapse of ΔΨm with cytoplasmic fluorescence. Scale bar = 50μm. (B) Kinetics of changes of ΔΨm was showed as the ratio of red to green fluorescence in each treatment staining with JC-1 at 0.5, 6, 12, 24, 48, 72 and 96 h after X-ray radiation (IR) with or without 10μM BTB treatment. Data are expressed as means±SD of triplicate measurements. IR compared with IR+BTB, *p< 0.05, **p< 0.01, t-test. Control compared with IR+BTB, #p< 0.05, ##p< 0.01, t-test.

    Oncotarget, 2017, doi: 10.18632/oncotarget.18657. BTB06584 purchased from Selleck.

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Biological Activity

Description BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase.
F1 Fo-ATPase [1]
In vitro

BTB06584 IF1-dependently inhibits F1 Fo-ATPase activity with no effect on without compromising ATP synthesis, and also limits ischemia-induced injury caused by reversal of the mitochondrial F1 Fo-ATP synthase. [1]

In vivo BTB06584 rescues the defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants without causing significant toxicity. [1]


Solubility (25°C)

In vitro DMSO 84 mg/mL (201.04 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 417.82


CAS No. 219793-45-0
Storage powder
in solvent
Synonyms N/A
Smiles [O-][N+](=O)C1=CC=C(C=C1OC(=O)C2=CC=C(Cl)C=C2)[S](=O)(=O)C3=CC=CC=C3

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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